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Select item 63429691.

Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice

Hyeonwi Son, Sujeong Kim, Doo-hyuk Jung, Ji Hyeong Baek, Dong Hoon Lee, Gu Seob Roh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Dong Kun Lee, Hyun Joon Kim

Sci Rep. 2019; 9: 252. Published online 2019 Jan 22. doi: 10.1038/s41598-018-36619-2

PMCID:: PMC6342969

Abstract Article PDF–5.2M

Select item 53469562.

Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells

Erika M. Palmieri, Alessio Menga, Aurore Lebrun, Douglas C. Hooper, D. Allan Butterfield, Massimiliano Mazzone, Alessandra Castegna

Antioxid Redox Signal. 2017 Mar 10; 26(8): 351–363. Published online 2017 Mar 10. doi: 10.1089/ars.2016.6715

PMCID:: PMC5346956

Abstract Article PDF–664K

Select item 37915223.

Astrocytes and glutamate homoeostasis in Alzheimer's disease: a decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex

Magdalena Kulijewicz-Nawrot, Eva Syková, Alexander Chvátal, Alexei Verkhratsky, José J. Rodríguez

ASN Neuro. 2013; 5(4): e00123. Prepublished online 2013 Sep 23. Published online 2013 Oct 7. doi: 10.1042/AN20130017

PMCID:: PMC3791522

Abstract Article PDF–738K

Select item 37612014.

Expression of glutamine synthetase in the mouse kidney: localization in multiple epithelial cell types and differential regulation by hypokalemia

Jill W. Verlander, Diana Chu, Hyun-Wook Lee, Mary E. Handlogten, I. David Weiner

Am J Physiol Renal Physiol. 2013 Sep 1; 305(5): F701–F713. Published online 2013 Jun 26. doi: 10.1152/ajprenal.00030.2013

PMCID:: PMC3761201

Abstract Article

Select item 28432025.

Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and Extrahepatic Ammonia Detoxification

Youji He, Theodorus B. M. Hakvoort, S. Eleonore Köhler, Jacqueline L. M. Vermeulen, D. Rudi de Waart, Chiel de Theije, Gabrie A. M. ten Have, Hans M. H. van Eijk, Cindy Kunne, Wilhelmina T. Labruyere, Sander M. Houten, Milka Sokolovic, Jan M. Ruijter, Nicolaas E. P. Deutz, Wouter H. Lamers

J Biol Chem. 2010 Mar 26; 285(13): 9516–9524. Published online 2010 Jan 11. doi: 10.1074/jbc.M109.092429

PMCID:: PMC2843202

Abstract Article PDF–2.3M

Select item 12183626.

Role of the 5' enhancer of the glutamine synthetase gene in its organ-specific expression.

H Lie-Venema, P A de Boer, A F Moorman, W H Lamers

Biochem J. 1997 May 1; 323(Pt 3): 611–619. doi: 10.1042/bj3230611

PMCID:: PMC1218362

Summary PDF–568K

Select item 85022057.

Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes

Lucile Ben Haim, Lucas Schirmer, Amel Zulji, Khalida Sabeur, Brice Tiret, Matthieu Ribon, Sandra Chang, Wouter H. Lamers, Séverine BoillEée, Myriam M. Chaumeil, David H. Rowitch

Glia. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Glia. 2021 Dec; 69(12): 2812–2827. Published online 2021 Aug 15. doi: 10.1002/glia.24071

PMCID:: PMC8502205

Abstract Article PDF–3.5M

Select item 55752338.

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Erika M. Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, Douglas C. Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, Alessandra Castegna

Cell Rep. 2017 Aug 15; 20(7): 1654–1666. Published online 2017 Aug 15. doi: 10.1016/j.celrep.2017.07.054

PMCID:: PMC5575233

Abstract Article

Select item 55388409.

Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction

Hyun-Wook Lee, Gunars Osis, Mary E. Handlogten, Jill W. Verlander, I. David Weiner

Am J Physiol Renal Physiol. 2017 Jul 1; 313(1): F116–F125. Published online 2017 Mar 22. doi: 10.1152/ajprenal.00048.2017

PMCID:: PMC5538840

Abstract Article

Select item 493577010.

Proximal tubule-specific glutamine synthetase deletion alters basal and acidosis-stimulated ammonia metabolism

Hyun-Wook Lee, Gunars Osis, Mary E. Handlogten, Wouter H. Lamers, Farrukh A. Chaudhry, Jill W. Verlander, I. David Weiner

Am J Physiol Renal Physiol. 2016 Jun 1; 310(11): F1229–F1242. Published online 2016 Mar 23. doi: 10.1152/ajprenal.00547.2015

PMCID:: PMC4935770

Abstract Article

Select item 491531911.

Thioredoxin-Interacting Protein (TXNIP) Suppresses Expression of Glutamine Synthetase by Inducing Oxidative Stress in Retinal Muller Glia Under Diabetic Conditions

Jia Zhou, Xi Shen, Qiong Lu, Min Zhang

Med Sci Monit. 2016; 22: 1460–1466. Published online 2016 May 1. doi: 10.12659/MSM.895916

PMCID:: PMC4915319

Abstract Article PDF–1.1M

Select item 441891912.

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase

Natalia Qvartskhava, Philipp A. Lang, Boris Görg, Vitaly I. Pozdeev, Marina Pascual Ortiz, Karl S. Lang, Hans J. Bidmon, Elisabeth Lang, Christina B. Leibrock, Diran Herebian, Johannes G. Bode, Florian Lang, Dieter Häussinger

Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17): 5521–5526. Published online 2015 Apr 13. doi: 10.1073/pnas.1423968112

PMCID:: PMC4418919

Abstract Article PDF–1.2M

Select item 420024113.

Glutamine Synthetase Stability and Subcellular Distribution in Astrocytes Are Regulated by γ-Aminobutyric Type B Receptors

Deborah Huyghe, Yasuko Nakamura, Miho Terunuma, Mathilde Faideau, Philip Haydon, Menelas N. Pangalos, Stephen J. Moss

J Biol Chem. 2014 Oct 17; 289(42): 28808–28815. Published online 2014 Aug 29. doi: 10.1074/jbc.M114.583534

PMCID:: PMC4200241

Abstract Article PDF–1.5M

Select item 185022814.

Glutamine, insulin and glucocorticoids regulate glutamine synthetase expression in C2C12 myotubes, Hep G2 hepatoma cells and 3T3 L1 adipocytes

Yanxin Wang, Malcolm Watford

Biochim Biophys Acta. Author manuscript; available in PMC 2008 Apr 1.

Published in final edited form as: Biochim Biophys Acta. 2007 Apr; 1770(4): 594–600. Published online 2006 Nov 23. doi: 10.1016/j.bbagen.2006.11.007

PMCID:: PMC1850228

Abstract Article PDF–384K

Select item 688612515.

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong

Cell Rep. Author manuscript; available in PMC 2019 Dec 2.

Published in final edited form as: Cell Rep. 2019 Oct 29; 29(5): 1287–1298.e6. doi: 10.1016/j.celrep.2019.09.056

PMCID:: PMC6886125

Abstract Article PDF–2.6M

Select item 654417516.

Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase

Wendy Xin, Yevgeniya A. Mironova, Hui Shen, Rosa A.M. Marino, Ari Waisman, Wouter H. Lamers, Dwight E. Bergles, Antonello Bonci

Cell Rep. Author manuscript; available in PMC 2019 May 31.

Published in final edited form as: Cell Rep. 2019 May 21; 27(8): 2262–2271.e5. doi: 10.1016/j.celrep.2019.04.094

PMCID:: PMC6544175

Abstract Article PDF–2.8M

Select item 826190417.

Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration

Yun Zhou, Roni Dhaher, Maxime Parent, Qiu-Xiang Hu, Bjørnar Hassel, Yee Siu-Pok, Fahmeed Hyder, Shaun E Gruenbaum, Tore Eid, Niels Christian Danbolt

Neurochem Int. Author manuscript; available in PMC 2021 Jul 7.

Published in final edited form as: Neurochem Int. 2019 Feb; 123: 22–33. Published online 2018 Jul 24. doi: 10.1016/j.neuint.2018.07.009

PMCID:: PMC8261904

Abstract Article PDF–1.3M

Select item 711684418.

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

Min Shang, Federica Cappellesso, Ricardo Amorim, Jens Serneels, Federico Virga, Guy Eelen, Stefania Carobbio, Melvin Y. Rincon, Pierre Maechler, Katrien De Bock, Ping-Chih Ho, Marco Sandri, Bart Ghesquiere, Peter Carmeliet, Mario Di Matteo, Emanuele Berardi, Massimiliano Mazzone

Nature. Author manuscript; available in PMC 2021 Apr 28.

Published in final edited form as: Nature. 2020 Nov 1; 587(7835): 626–631. Published online 2020 Oct 28. doi: 10.1038/s41586-020-2857-9

PMCID:: PMC7116844

Abstract Article PDF–5.9M

Select item 580746619.

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway

Zoë D. Burke, Karen R. Reed, Sheng-Wen Yeh, Valerie Meniel, Owen J. Sansom, Alan R. Clarke, David Tosh

Sci Rep. 2018; 8: 2735. Published online 2018 Feb 9. doi: 10.1038/s41598-018-20888-y

Correction in:: Sci Rep. 2020; 10: 11169.

PMCID:: PMC5807466

Abstract Article PDF–11M

Select item 358148120.

Comparative Analysis of the Expression Profile of Wnk1 and Wnk1/Hsn2 Splice Variants in Developing and Adult Mouse Tissues

Masoud Shekarabi, Ron G. Lafrenière, Rébecca Gaudet, Janet Laganière, Martin M. Marcinkiewicz, Patrick A. Dion, Guy A. Rouleau

PLoS One. 2013; 8(2): e57807. Published online 2013 Feb 25. doi: 10.1371/journal.pone.0057807

PMCID:: PMC3581481

Abstract Article PDF–1.6M

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