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Select item 106390251.

Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice

Swayam Prakash Srivastava, Julie E. Goodwin

Am J Physiol Renal Physiol. 2023 Oct 1; 325(4): F519–F526. Published online 2023 Aug 17. doi: 10.1152/ajprenal.00105.2023

PMCID:: PMC10639025

Article

Select item 97061562.

Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

Katrine D. Galsgaard, Emilie Elmelund, Christian D. Johansen, Anna B. Bomholt, Hüsün S. Kizilkaya, Frederik Ceutz, Jenna E. Hunt, Hannelouise Kissow, Marie Winther-Sørensen, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Mette M. Rosenkilde, Cathrine Ørskov, Christina Christoffersen, Jens J. Holst, Nicolai J. Wewer Albrechtsen

Mol Metab. 2022 Dec; 66: 101639. Published online 2022 Nov 15. doi: 10.1016/j.molmet.2022.101639

PMCID:: PMC9706156

Article PDF–2.9M

Select item 96187713.

Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells

Emilie Elmelund, Katrine D. Galsgaard, Christian D. Johansen, Samuel A.J. Trammell, Anna B. Bomholt, Marie Winther-Sørensen, Jenna E. Hunt, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Trisha J. Grevengoed, Jens J. Holst, Nicolai J. Wewer Albrechtsen

iScience. 2022 Nov 18; 25(11): 105296. Published online 2022 Oct 6. doi: 10.1016/j.isci.2022.105296

PMCID:: PMC9618771

Article PDF–2.9M

Select item 95761804.

Glucagon receptor signaling at white adipose tissue does not regulate lipolysis

Anastasiia Vasileva, Tyler Marx, Jacqueline L. Beaudry, Jennifer H. Stern

Am J Physiol Endocrinol Metab. 2022 Oct 1; 323(4): E389–E401. Published online 2022 Aug 24. doi: 10.1152/ajpendo.00078.2022

PMCID:: PMC9576180

Article

Select item 81814115.

Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors

Jenna Elizabeth Hunt, Mohammad Yassin, Jørgen Olsen, Bolette Hartmann, Jens Juul Holst, Hannelouise Kissow

Front Endocrinol (Lausanne) 2021; 12: 695145. Published online 2021 May 24. doi: 10.3389/fendo.2021.695145

PMCID:: PMC8181411

Article PDF–945K

Select item 81735276.

Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver–α-cell axis

Qiaofeng Liu, Guangyao Lin, Yan Chen, Wenbo Feng, Yingna Xu, Jianjun Lyu, Dehua Yang, Ming-Wei Wang

Biosci Rep. 2021 Jun 25; 41(6): BSR20210758. Published online 2021 Jun 2. doi: 10.1042/BSR20210758

PMCID:: PMC8173527

Article PDF–3.4M

Select item 79363187.

Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets

May-Yun Wang, E. Danielle Dean, Ezekiel Quittner-Strom, Yi Zhu, Kamrul H. Chowdhury, Zhuzhen Zhang, Shangang Zhao, Na Li, Reshing Ye, Young Lee, Yiyi Zhang, Shiuhwei Chen, Xinxin Yu, Derek C. Leonard, Greg Poffenberger, Alison Von Deylen, S. Kay McCorkle, Amnon Schlegel, Kyle W. Sloop, Alexander M. Efanov, Ruth E. Gimeno, Philipp E. Scherer, Alvin C. Powers, Roger H. Unger, William L. Holland

Proc Natl Acad Sci U S A. 2021 Mar 2; 118(9): e2022142118. Published online 2021 Feb 22. doi: 10.1073/pnas.2022142118

PMCID:: PMC7936318

Article PDF–2.4M

Select item 60483898.

Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

Katrine D. Galsgaard, Marie Winther-Sørensen, Cathrine Ørskov, Hannelouise Kissow, Steen S. Poulsen, Hendrik Vilstrup, Cornelia Prehn, Jerzy Adamski, Sara L. Jepsen, Bolette Hartmann, Jenna Hunt, Maureen J. Charron, Jens Pedersen, Nicolai J. Wewer Albrechtsen, Jens J. Holst

Am J Physiol Endocrinol Metab. 2018 Jan 1; 314(1): E93–E103. Published online 2017 Oct 3. doi: 10.1152/ajpendo.00198.2017

PMCID:: PMC6048389

Article

Select item 38410479.

Oxyntomodulin increases intrinsic heart rate through the glucagon receptor

Auyon Mukharji, Daniel J Drucker, Maureen J Charron, Steven J Swoap

Physiol Rep. 2013 Oct; 1(5): e00112. Published online 2013 Oct 20. doi: 10.1002/phy2.112

PMCID:: PMC3841047

Article PDF–768K

Select item 338030910.

Regulation of Mouse Intestinal L Cell Progenitors Proliferation by the Glucagon Family of Peptides

Marine Grigoryan, Mamdouh H. Kedees, Maureen J. Charron, Yelena Guz, Gladys Teitelman

Endocrinology. 2012 Jul; 153(7): 3076–3088. Published online 2012 May 8. doi: 10.1210/en.2012-1120

PMCID:: PMC3380309

Article

Select item 331742911.

Partial Rescue of Retinal Function in Chronically Hypoglycemic Mice

Yumiko Umino, Nicolas Cuenca, Drew Everhart, Laura Fernandez-Sanchez, Robert B. Barlow, Eduardo Solessio

Invest Ophthalmol Vis Sci. 2012 Feb; 53(2): 915–923. Published online 2012 Feb 21. doi: 10.1167/iovs.11-8787

PMCID:: PMC3317429

Article PDF–1.9M

Select item 315442412.

Pancreatic Neuroendocrine Tumors in Glucagon Receptor-Deficient Mice

Run Yu, Deepti Dhall, Nicholas N. Nissen, Cuiqi Zhou, Song-Guang Ren

PLoS One. 2011; 6(8): e23397. Published online 2011 Aug 10. doi: 10.1371/journal.pone.0023397

PMCID:: PMC3154424

Article PDF–1.1M

Select item 313071013.

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Jianxin Yang, Margit L MacDougall, Michael T McDowell, Li Xi, Ru Wei, William J Zavadoski, Mark P Molloy, John D Baker, Max Kuhn, Over Cabrera, Judith L Treadway

BMC Genomics. 2011; 12: 281. Published online 2011 Jun 1. doi: 10.1186/1471-2164-12-281

PMCID:: PMC3130710

Article PDF–263K

Select item 302833714.

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

Young Lee, May-Yun Wang, Xiu Quan Du, Maureen J. Charron, Roger H. Unger

Diabetes. 2011 Feb; 60(2): 391–397. Published online 2011 Jan 21. doi: 10.2337/db10-0426

PMCID:: PMC3028337

Article PDF–840K

Select item 273969515.

Pancreatic β-cell overexpression of the glucagon receptor gene results in enhanced β-cell function and mass

Richard W. Gelling, Patricia M. Vuguin, Xiu Quan Du, Lingguang Cui, John Rømer, Raymond A. Pederson, Margarita Leiser, Heidi Sørensen, Jens J. Holst, Christian Fledelius, Peter B. Johansen, Norman Fleischer, Christopher H. S. McIntosh, Erica Nishimura, Maureen J. Charron

Am J Physiol Endocrinol Metab. 2009 Sep; 297(3): E695–E707. Published online 2009 Jul 14. doi: 10.1152/ajpendo.00082.2009

PMCID:: PMC2739695

Article

Select item 169783216.

Hypoglycemia leads to age-related loss of vision

Y. Umino, D. Everhart, E. Solessio, K. Cusato, J. C. Pan, T. H. Nguyen, E. T. Brown, R. Hafler, B. A. Frio, B. E. Knox, G. A. Engbretson, M. Haeri, L. Cui, A. S. Glenn, M. J. Charron, R. B. Barlow

Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51): 19541–19545. Published online 2006 Dec 11. doi: 10.1073/pnas.0604478104

PMCID:: PMC1697832

Article PDF–1.0M

Select item 860498317.

A glucagon analogue decreases body weight in mice via signalling in the liver

Charlotte E. Hinds, Bryn M. Owen, David C. D. Hope, Philip Pickford, Ben Jones, Tricia M. Tan, James S. Minnion, Stephen R. Bloom

Sci Rep. 2021; 11: 22577. Published online 2021 Nov 19. doi: 10.1038/s41598-021-01912-0

PMCID:: PMC8604983

Article PDF–1.2M

Select item 820695818.

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Jinrang Kim, Haruka Okamoto, ZhiJiang Huang, Guillermo Anguiano, Shiuhwei Chen, Qing Liu, Katie Cavino, Yurong Xin, Erqian Na, Rachid Hamid, Joseph Lee, Brian Zambrowicz, Roger Unger, Andrew J. Murphy, Yan Xu, George D. Yancopoulos, Wen-hong Li, Jesper Gromada

Cell Metab. Author manuscript; available in PMC 2021 Jun 16.

Published in final edited form as: Cell Metab. 2017 Jun 6; 25(6): 1348–1361.e8. doi: 10.1016/j.cmet.2017.05.006

PMCID:: PMC8206958

Article PDF–3.1M

Select item 619767519.

Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia

Belen Rivero-Gutierrez, April Haller, Jenna Holland, Emily Yates, Radha Khrisna, Kirk Habegger, Richard Dimarchi, David D'Alessio, Diego Perez-Tilve

Mol Metab. 2018 Nov; 17: 28–38. Published online 2018 Aug 20. doi: 10.1016/j.molmet.2018.07.012

PMCID:: PMC6197675

Article PDF–1.0M

Select item 534755020.

Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice

Haruka Okamoto, Katie Cavino, Erqian Na, Elizabeth Krumm, Sun Y. Kim, Xiping Cheng, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada

Proc Natl Acad Sci U S A. 2017 Mar 7; 114(10): 2753–2758. Published online 2017 Jan 23. doi: 10.1073/pnas.1621069114

PMCID:: PMC5347550

Article PDF–1.1M

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