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Select item 100731241.

FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells

Chen Wang, Hui Sun, John S. Davis, Xiaojie Wang, Lijun Huo, Nan Sun, Qianzhi Huang, Xiangmin Lv, Cheng Wang, Chunbo He, Changjiu He, Yang Zhou, Jiyun Wu, Liguo Yang, Guohua Hua

Cell Death Dis. 2023 Apr; 14(4): 239. Published online 2023 Apr 5. doi: 10.1038/s41419-023-05759-3

PMCID:: PMC10073124

Article PDF–5.6M

Select item 94779482.

Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes

Jayron J. Habibe, Maria P. Clemente-Olivo, Torsten P. M. Scheithauer, Elena Rampanelli, Hilde Herrema, Mariska Vos, Arnout Mieremet, Max Nieuwdorp, Daniel H. van Raalte, Etto C. Eringa, Carlie J. M. de Vries

Diabetologia. 2022; 65(10): 1721–1733. Published online 2022 Jul 8. doi: 10.1007/s00125-022-05750-1

PMCID:: PMC9477948

Article PDF–2.5M

Select item 69333993.

Deletion of the FHL2 gene attenuates intima‐media thickening in a partially ligated carotid artery ligated mouse model

Chi‐Yu Chen, Hsiao‐Ya Tsai, Shih‐Hung Tsai, Pao‐Hsien Chu, Po‐Hsun Huang, Jaw‐Wen Chen, Shing‐Jong Lin

J Cell Mol Med. 2020 Jan; 24(1): 160–173. Published online 2019 Nov 12. doi: 10.1111/jcmm.14687

PMCID:: PMC6933399

Article PDF–2.2M

Select item 39881364.

The LIM-Only Protein FHL2 Reduces Vascular Lesion Formation Involving Inhibition of Proliferation and Migration of Smooth Muscle Cells

Kondababu Kurakula, Mariska Vos, Iker Otermin Rubio, Goran Marinković, Reinhard Buettner, Lukas C. Heukamp, Jan Stap, Vivian de Waard, Claudia M. van Tiel, Carlie J.M. de Vries

PLoS One. 2014; 9(4): e94931. Published online 2014 Apr 15. doi: 10.1371/journal.pone.0094931

PMCID:: PMC3988136

Article PDF–6.5M

Select item 37447665.

The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription

Anke Renger, Maria-Patapia Zafiriou, Claudia Noack, Elena Pavlova, Alexander Becker, Krasimira Sharkova, Martin W Bergmann, Ali El-Armouche, Wolfram-Hubertus Zimmermann, Laura C Zelarayán

Stem Cells. 2013 May; 31(5): 928–940. Published online 2013 Jan 22. doi: 10.1002/stem.1332

PMCID:: PMC3744766

Article PDF–1.2M

Select item 35622036.

Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice

Sebastian Huss, Christian Stellmacher, Diane Goltz, Inna Khlistunova, Alexander C Adam, Jonel Trebicka, Jutta Kirfel, Reinhard Büttner, Ralf Weiskirchen

BMC Gastroenterol. 2013; 13: 8. Published online 2013 Jan 14. doi: 10.1186/1471-230X-13-8

PMCID:: PMC3562203

Article PDF–1.9M

Select item 29039587.

Disruption of Four-and-a-Half LIM 2 Decreases Bone Mineral Content and Bone Mineral Density in Femur and Tibia Bones of Female Mice

K. E. Govoni, D. J. Baylink, J. Chen, S. Mohan

Calcif Tissue Int. Author manuscript; available in PMC 2010 Jul 14.

Published in final edited form as: Calcif Tissue Int. 2006 Aug; 79(2): 112–117. Published online 2006 Aug 15. doi: 10.1007/s00223-006-0074-7

PMCID:: PMC2903958

Article PDF–233K

Select item 27385848.

Deletion of the FHL2 Gene Attenuating Neovascularization after Corneal Injury

Pao-Hsien Chu, Lung-Kun Yeh, Hsin-Chiung Lin, Shih-Ming Jung, David Hui-Kang Ma, I-Jong Wang, Hsueh-Hua Wu, Tzu-Fang Shiu, Ju Chen

Invest Ophthalmol Vis Sci. Author manuscript; available in PMC 2009 Dec 1.

Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Dec; 49(12): 5314–5318. Published online 2008 Aug 15. doi: 10.1167/iovs.08-2209

PMCID:: PMC2738584

Article PDF–1.2M

Select item 20641209.

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

Viktor Wixler, Stephanie Hirner, Judith M. Müller, Lucia Gullotti, Carola Will, Jutta Kirfel, Thomas Günther, Holm Schneider, Anja Bosserhoff, Hubert Schorle, Jung Park, Roland Schüle, Reinhard Buettner

J Cell Biol. 2007 Apr 9; 177(1): 163–172. doi: 10.1083/jcb.200606043

PMCID:: PMC2064120

Article PDF–2.1M

Select item 8629910.

FHL2 (SLIM3) Is Not Essential for Cardiac Development and Function

Po-Hsien Chu, Wendy M. Bardwell, Yusu Gu, John Ross, Jr., Ju Chen

Mol Cell Biol. 2000 Oct; 20(20): 7460–7462. doi: 10.1128/mcb.20.20.7460-7462.2000

PMCID:: PMC86299

Article PDF–119K

Select item 1057362911.

Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity

Judith Sommer, Hanna Ehnis, Tatjana Seitz, Julia Schneider, Andreas B. Wild, Sandra Moceri, Christa Buechler, Aline Bozec, Georg F. Weber, Susanne Merkel, Ruth Beckervordersandforth, Alexander Steinkasserer, Roland Schüle, Jonel Trebicka, Arndt Hartmann, Anja Bosserhoff, Stephan von Hörsten, Peter Dietrich, Claus Hellerbrand

Int J Mol Sci. 2023 Oct; 24(19): 14943. Published online 2023 Oct 6. doi: 10.3390/ijms241914943

PMCID:: PMC10573629

Article PDF–3.0M

Select item 727160312.

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

Chantal Kroone, Mariska Vos, Timo Rademakers, Marijke Kuijpers, Mark Hoogenboezem, Jaap van Buul, Johan W.M. Heemskerk, Wolfram Ruf, Astrid van Hylckama Vlieg, Henri H. Versteeg, Marie-José Goumans, Carlie J.M. de Vries, Kondababu Kurakula, INVENT Consortium

Haematologica. 2020 Jun; 105(6): 1677–1685. Prepublished online 2019 Aug 29. doi: 10.3324/haematol.2018.203026

PMCID:: PMC7271603

Article PDF–3.5M

Select item 701669013.

Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury

Judith Sommer, Christoph Dorn, Erwin Gäbele, Frauke Bataille, Kim Freese, Tatjana Seitz, Wolfgang E. Thasler, Reinhard Büttner, Ralf Weiskirchen, Anja Bosserhoff, Claus Hellerbrand

Cells. 2020 Jan; 9(1): 248. Published online 2020 Jan 19. doi: 10.3390/cells9010248

PMCID:: PMC7016690

Article PDF–1.9M

Select item 547755314.

LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression

Jennifer Dahan, Florence Levillayer, Tian Xia, Yann Nouët, Catherine Werts, Martine Fanton d'Andon, Minou Adib-Conquy, Anne-Marie Cassard-Doulcier, Varun Khanna, Ju Chen, Thierry Tordjmann, Marie-Annick Buendia, Grégory Jouvion, Yu Wei

Mol Cell Biol. 2017 May 15; 37(10): e00636-16. Prepublished online 2017 Feb 21. Published online 2017 May 2. doi: 10.1128/MCB.00636-16

PMCID:: PMC5477553

Article PDF–3.5M

Select item 465783915.

Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease

Szu-Yuan Li, Po-Hsun Huang, Der-Cherng Tarng, Tzu-Ping Lin, Wu-Chang Yang, Yen-Hwa Chang, An-Hang Yang, Chih-Ching Lin, Muh-Hwa Yang, Jaw-Wen Chen, Geert W. Schmid-Schönbein, Shu Chien, Pao-Hsien Chu, Shing-Jong Lin

J Am Soc Nephrol. 2015 Dec; 26(12): 3072–3084. Published online 2015 Apr 8. doi: 10.1681/ASN.2014100989

PMCID:: PMC4657839

Article

Select item 434655316.

FHL2 regulates hematopoietic stem cell functions under stress conditions

Yu Hou, Xiaoqin Wang, LiPing Li, Rong Fan, Ju Chen, Tongyu Zhu, Wen Li, Yanwen Jiang, Nupur Mittal, Wenshu Wu, David Peace, Zhijian Qian

Leukemia. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Leukemia. 2015 Mar; 29(3): 615–624. Published online 2014 Sep 2. doi: 10.1038/leu.2014.254

PMCID:: PMC4346553

Article PDF–757K

Select item 383260417.

The LIM-Only Protein FHL2 Attenuates Lung Inflammation during Bleomycin-Induced Fibrosis

Abdulaleem Alnajar, Carolin Nordhoff, Tanja Schied, Ruth Chiquet-Ehrismann, Karin Loser, Thomas Vogl, Stephan Ludwig, Viktor Wixler

PLoS One. 2013; 8(11): e81356. Published online 2013 Nov 18. doi: 10.1371/journal.pone.0081356

PMCID:: PMC3832604

Article PDF–3.7M

Select item 375391918.

LIM-Only Protein FHL2 Activates NF-κB Signaling in the Control of Liver Regeneration and Hepatocarcinogenesis

Jennifer Dahan, Yann Nouët, Grégory Jouvion, Florence Levillayer, Minou Adib-Conquy, Anne-Marie Cassard-Doulcier, Ali Tebbi, Fany Blanc, Lauriane Remy, Ju Chen, Stefano Cairo, Catherine Werts, Mustapha Si-Tahar, Thierry Tordjmann, Marie-Annick Buendia, Yu Wei

Mol Cell Biol. 2013 Aug; 33(16): 3299–3308. doi: 10.1128/MCB.00105-13

PMCID:: PMC3753919

Article PDF–2.7M

Select item 325890419.

The LIM-only Protein FHL2 Regulates Cyclin D1 Expression and Cell Proliferation

Charlotte Labalette, Yann Nouët, Joëlle Sobczak-Thepot, Carolina Armengol, Florence Levillayer, Marie-Claude Gendron, Claire-Angélique Renard, Béatrice Regnault, Ju Chen, Marie-Annick Buendia, Yu Wei

J Biol Chem. 2008 May 30; 283(22): 15201–15208. doi: 10.1074/jbc.M800708200

PMCID:: PMC3258904

Article PDF–562K

Select item 217349920.

The LIM-only protein FHL2 interacts with β-catenin and promotes differentiation of mouse myoblasts

Bernd Martin, Richard Schneider, Stefanie Janetzky, Zoe Waibler, Petra Pandur, Michael Kühl, Jürgen Behrens, Klaus von der Mark, Anna Starzinski-Powitz, Viktor Wixler

J Cell Biol. 2002 Oct 14; 159(1): 113–122. doi: 10.1083/jcb.200202075

PMCID:: PMC2173499

Article PDF–339K

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