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Select item 110121181.

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles

George Haddad, Judith Blaine

Cells. 2024 Apr; 13(7): 594. Published online 2024 Mar 29. doi: 10.3390/cells13070594

PMCID:: PMC11012118

Article PDF–13M

Select item 106281752.

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

Weizhong Li, Tao Wang, Arunraj M. Rajendrakumar, Gyanada Acharya, Zizhen Miao, Berin P. Varghese, Hailiang Yu, Bibek Dhakal, Tanya LeRoith, Athira Karunakaran, Wenbin Tuo, Xiaoping Zhu

Nat Commun. 2023; 14: 7114. Published online 2023 Nov 6. doi: 10.1038/s41467-023-42796-0

PMCID:: PMC10628175

Article PDF–1.9M

Select item 101128103.

Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes

George Haddad, James Dylewski, River Evans, Linda Lewis, Judith Blaine

PLoS One. 2023; 18(4): e0284636. Published online 2023 Apr 18. doi: 10.1371/journal.pone.0284636

PMCID:: PMC10112810

Article PDF–2.4M

Select item 95375314.

DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2

Elizabeth M. Parzych, Jianqiu Du, Ali R. Ali, Katherine Schultheis, Drew Frase, Trevor R. F. Smith, Jiayan Cui, Neethu Chokkalingam, Nicholas J. Tursi, Viviane M. Andrade, Bryce M. Warner, Ebony N. Gary, Yue Li, Jihae Choi, Jillian Eisenhauer, Igor Maricic, Abhijeet Kulkarni, Jacqueline D. Chu, Gabrielle Villafana, Kim Rosenthal, Kuishu Ren, Joseph R. Francica, Sarah K. Wootton, Pablo Tebas, Darwyn Kobasa, Kate E. Broderick, Jean D. Boyer, Mark T. Esser, Jesper Pallesen, Dan W. Kulp, Ami Patel, David B. Weiner

Nat Commun. 2022; 13: 5886. Published online 2022 Oct 6. doi: 10.1038/s41467-022-33309-6

PMCID:: PMC9537531

Article PDF–4.0M

Select item 88868155.

Dynamics of intracellular neonatal Fc receptor–ligand interactions in primary macrophages using biophysical fluorescence techniques

Andreas Pannek, Fiona J. Houghton, Anne M. Verhagen, Steven K. Dower, Elizabeth Hinde, Paul A. Gleeson

Mol Biol Cell. 2022 Jan 1; 33(1): ar6. doi: 10.1091/mbc.E21-02-0061

PMCID:: PMC8886815

Article PDF–3.6M

Select item 88001096.

Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life

Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Stian Foss, Kine Marita Knudsen Sand, Thomas Emrich, Jens Andre Alexander Fischer, Victor Greiff, Inger Sandlie, Tilman Schlothauer, Jan Terje Andersen

iScience. 2022 Feb 18; 25(2): 103746. Published online 2022 Jan 10. doi: 10.1016/j.isci.2022.103746

PMCID:: PMC8800109

Article PDF–4.2M

Select item 77694257.

Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis

James F. Dylewski, Pantipa Tonsawan, Gabriela Garcia, Linda Lewis, Judith Blaine

PLoS One. 2020; 15(12): e0230401. Published online 2020 Dec 28. doi: 10.1371/journal.pone.0230401

PMCID:: PMC7769425

Article PDF–2.4M

Select item 75777408.

A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch

Zijun Wang, Christopher O Barnes, Rajeev Gautam, Julio C Cetrulo Lorenzi, Christian T Mayer, Thiago Y Oliveira, Victor Ramos, Melissa Cipolla, Kristie M Gordon, Harry B Gristick, Anthony P West, Yoshiaki Nishimura, Henna Raina, Michael S Seaman, Anna Gazumyan, Malcolm Martin, Pamela J Bjorkman, Michel C Nussenzweig, Amelia Escolano

eLife. 2020; 9: e61991. Published online 2020 Oct 21. doi: 10.7554/eLife.61991

PMCID:: PMC7577740

Article PDF–2.8M

Select item 68798809.

Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton

Pantipa Tonsawan, James Dylewski, Linda Lewis, Judith Blaine

Am J Physiol Cell Physiol. 2019 Nov 1; 317(5): C1048–C1060. Published online 2019 Sep 25. doi: 10.1152/ajpcell.00235.2019

PMCID:: PMC6879880

Article

Select item 683467810.

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Chang-Han Lee, Tae Hyun Kang, Ophélie Godon, Makiko Watanabe, George Delidakis, Caitlin M. Gillis, Delphine Sterlin, David Hardy, Michel Cogné, Lynn E. Macdonald, Andrew J. Murphy, Naxin Tu, Jiwon Lee, Jonathan R. McDaniel, Emily Makowski, Peter M. Tessier, Aaron S. Meyer, Pierre Bruhns, George Georgiou

Nat Commun. 2019; 10: 5031. Published online 2019 Nov 6. doi: 10.1038/s41467-019-13108-2

Correction in:: Nat Commun. 2019; 10: 5461.

PMCID:: PMC6834678

Article PDF–1.4M

Select item 617230811.

Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment

Diana Cadena Castaneda, Christine Dhommée, Thomas Baranek, Emilie Dalloneau, Laurie Lajoie, Alexandre Valayer, Christophe Arnoult, Marie-Véronique Demattéi, Delphine Fouquenet, Christelle Parent, Nathalie Heuzé-Vourc'h, Valérie Gouilleux-Gruart

Front Immunol. 2018; 9: 2259. Published online 2018 Sep 28. doi: 10.3389/fimmu.2018.02259

PMCID:: PMC6172308

Article PDF–1.7M

Select item 496883412.

Generation and Characterization of an IgG4 Monomeric Fc Platform

Lu Shan, Magali Colazet, Kim L. Rosenthal, Xiang-Qing Yu, Jared S. Bee, Andrew Ferguson, Melissa M. Damschroder, Herren Wu, William F. Dall’Acqua, Ping Tsui, Vaheh Oganesyan

PLoS One. 2016; 11(8): e0160345. Published online 2016 Aug 1. doi: 10.1371/journal.pone.0160345

PMCID:: PMC4968834

Article PDF–1.7M

Select item 496811513.

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

Lindsay B. Avery, Mengmeng Wang, Mania S. Kavosi, Alison Joyce, Jeffrey C. Kurz, Yao-Yun Fan, Martin E. Dowty, Minlei Zhang, Yiqun Zhang, Aili Cheng, Fei Hua, Hannah M. Jones, Hendrik Neubert, Robert J. Polzer, Denise M. O'Hara

MAbs. 2016 Aug-Sep; 8(6): 1064–1078. Published online 2016 May 27. doi: 10.1080/19420862.2016.1193660

PMCID:: PMC4968115

Article PDF–1.3M

Select item 463494814.

Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells

Derek D. Sloan, Chia-Ying Kao Lam, Alivelu Irrinki, Liqin Liu, Angela Tsai, Craig S. Pace, Jasmine Kaur, Jeffrey P. Murry, Mini Balakrishnan, Paul A. Moore, Syd Johnson, Jeffrey L. Nordstrom, Tomas Cihlar, Scott Koenig

PLoS Pathog. 2015 Nov; 11(11): e1005233. Published online 2015 Nov 5. doi: 10.1371/journal.ppat.1005233

PMCID:: PMC4634948

Article PDF–3.2M

Select item 443477115.

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

Angela Schoch, Hubert Kettenberger, Olaf Mundigl, Gerhard Winter, Julia Engert, Julia Heinrich, Thomas Emrich

Proc Natl Acad Sci U S A. 2015 May 12; 112(19): 5997–6002. Published online 2015 Apr 27. doi: 10.1073/pnas.1408766112

PMCID:: PMC4434771

Article PDF–1.2M

Select item 400530016.

Neonatal Fc Receptor Promotes Immune Complex–Mediated Glomerular Disease

Florina Olaru, Wentian Luo, Hani Suleiman, Patricia L. St. John, Linna Ge, Adam R. Mezo, Andrey S. Shaw, Dale R. Abrahamson, Jeffrey H. Miner, Dorin-Bogdan Borza

J Am Soc Nephrol. 2014 May; 25(5): 918–925. Published online 2013 Dec 19. doi: 10.1681/ASN.2013050498

PMCID:: PMC4005300

Article

Select item 399041017.

The transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in an FcRn-dependent manner

Kyosuke Nakata, Kazuyuki Kobayashi, Yumiko Ishikawa, Masatsugu Yamamoto, Yasuhiro Funada, Yoshikazu Kotani, Richard S. Blumberg, Hajime Karasuyama, Masaru Yoshida, Yoshihiro Nishimura

Biochem Biophys Res Commun. Author manuscript; available in PMC 2014 Apr 17.

Published in final edited form as: Biochem Biophys Res Commun. 2010 Apr 30; 395(2): 238–243. Published online 2010 Apr 1. doi: 10.1016/j.bbrc.2010.03.170

PMCID:: PMC3990410

Article PDF–1.2M

Select item 396461418.

Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice

Y Ben Suleiman, M Yoshida, S Nishiumi, H Tanaka, T Mimura, K Nobutani, K Yamamoto, M Takenaka, A Aoganghua, I Miki, H Ota, S Takahashi, H Matsui, M Nakamura, RS Blumberg, T Azuma

Mucosal Immunol. Author manuscript; available in PMC 2014 Mar 25.

Published in final edited form as: Mucosal Immunol. 2012 Jan; 5(1): 87–98. Published online 2011 Nov 16. doi: 10.1038/mi.2011.53

PMCID:: PMC3964614

Article PDF–1.6M

Select item 390297019.

Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity Against Colorectal Cancer

Kristi Baker, Timo Rath, Magdalena B. Flak, Janelle C. Arthur, Zhangguo Chen, Jonathan N. Glickman, Inti Zlobec, Eva Karamitopoulou, Matthew D. Stachler, Robert D. Odze, Wayne I. Lencer, Christian Jobin, Richard S. Blumberg

Immunity. Author manuscript; available in PMC 2014 Dec 12.

Published in final edited form as: Immunity. 2013 Dec 12; 39(6): 1095–1107. Published online 2013 Nov 27. doi: 10.1016/j.immuni.2013.11.003

PMCID:: PMC3902970

Article PDF–4.9M

Select item 372660320.

Abundant Intracellular IgG in Enterocytes and Endoderm Lacking FcRn

Sudhasri Mohanty, Jonghan Kim, Latha P. Ganesan, Gary S. Phillips, John M. Robinson, Clark L. Anderson

PLoS One. 2013; 8(7): e70863. Published online 2013 Jul 29. doi: 10.1371/journal.pone.0070863

PMCID:: PMC3726603

Article PDF–9.2M

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