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Select item 84459871.

Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes

Nadine Hosny El Said, Francesco Della Valle, Peng Liu, Andreu Paytuví-Gallart, Sabir Adroub, Juliette Gimenez, Valerio Orlando

Cell Death Dis. 2021 Oct; 12(10): 850. Published online 2021 Sep 16. doi: 10.1038/s41419-021-04082-z

PMCID:: PMC8445987

Article PDF–3.3M

Select item 72636392.

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2

Dana Lau-Corona, Woo Kyun Bae, Lothar Hennighausen, David J. Waxman

PLoS Genet. 2020 May; 16(5): e1008796. Published online 2020 May 19. doi: 10.1371/journal.pgen.1008796

PMCID:: PMC7263639

Article PDF–4.5M

Select item 54774873.

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy

Julian C. Lui, Presley Garrison, Quang Nguyen, Michal Ad, Chithra Keembiyehetty, Weiping Chen, Youn Hee Jee, Ellie Landman, Ola Nilsson, Kevin M. Barnes, Jeffrey Baron

Nat Commun. 2016; 7: 13685. Published online 2016 Nov 29. doi: 10.1038/ncomms13685

PMCID:: PMC5477487

Article PDF–3.2M

Select item 50887834.

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

Melanie von Schimmelmann, Philip A. Feinberg, Josefa M. Sullivan, Stacy M. Ku, Ana Badimon, Mary Kaye Duff, Zichen Wang, Alexander Lachmann, Scott Dewell, Avi Ma'ayan, Ming-Hu Han, Alexander Tarakhovsky, Anne Schaefer

Nat Neurosci. Author manuscript; available in PMC 2017 Feb 15.

Published in final edited form as: Nat Neurosci. 2016 Oct; 19(10): 1321–1330. Published online 2016 Aug 15. doi: 10.1038/nn.4360

PMCID:: PMC5088783

Article PDF–944K

Select item 38777565.

Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin

Jinsook Son, Steven S. Shen, Raphael Margueron, Danny Reinberg

Genes Dev. 2013 Dec 15; 27(24): 2663–2677. doi: 10.1101/gad.225888.113

Correction in:: Genes Dev. 2014 Apr 15; 28(8): 921.

PMCID:: PMC3877756

Article PDF–2.5M

Select item 30492896.

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

Elena Ezhkova, Wen-Hui Lien, Nicole Stokes, H. Amalia Pasolli, Jose M. Silva, Elaine Fuchs

Genes Dev. 2011 Mar 1; 25(5): 485–498. doi: 10.1101/gad.2019811

PMCID:: PMC3049289

Article PDF–3.1M

Select item 65994547.

PRC2 proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Gene Expression at Promoter Regions in Euchromatin in Mice

Jessica Mae Grindheim, Dario Nicetto, Greg Donahue, Kenneth S Zaret

Gastroenterology. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Gastroenterology. 2019 May; 156(6): 1834–1848. Published online 2019 Jan 25. doi: 10.1053/j.gastro.2019.01.041

PMCID:: PMC6599454

Article PDF–4.5M

Select item 62232318.

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

Kazumasa Aoyama, Motohiko Oshima, Shuhei Koide, Emi Suzuki, Makiko Mochizuki-Kashio, Yuko Kato, Shiro Tara, Daisuke Shinoda, Nobuhiro Hiura, Yaeko Nakajima-Takagi, Goro Sashida, Atsushi Iwama

iScience. 2018 Nov 30; 9: 161–174. Published online 2018 Oct 15. doi: 10.1016/j.isci.2018.10.008

PMCID:: PMC6223231

Article PDF–3.6M

Select item 58814609.

Signaling function of PRC2 is essential for TCR-driven T cell responses

Marc-Werner Dobenecker, Joon Seok Park, Jonas Marcello, Michael T. McCabe, Richard Gregory, Steven D. Knight, Inmaculada Rioja, Anna K. Bassil, Rabinder K. Prinjha, Alexander Tarakhovsky

J Exp Med. 2018 Apr 2; 215(4): 1101–1113. doi: 10.1084/jem.20170084

PMCID:: PMC5881460

Article PDF–2.1M

Select item 534664210.

Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts

Wen-Si Zhu, Chun-Mei Tang, Zhen Xiao, Jie-Ning Zhu, Qiu-Xiong Lin, Yong-Heng Fu, Zhi-Qin Hu, Zhuo Zhang, Min Yang, Xi-Long Zheng, Shu-Lin Wu, Zhi-Xin Shan

Oncotarget. 2016 Nov 29; 7(48): 78331–78342. Published online 2016 Nov 3. doi: 10.18632/oncotarget.13048

PMCID:: PMC5346642

Article PDF–2.6M

Select item 371585411.

Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

Evan S Bardot, Victor J Valdes, Jisheng Zhang, Carolina N Perdigoto, Silvia Nicolis, Stephen A Hearn, Jose M Silva, Elena Ezhkova

EMBO J. 2013 Jul 17; 32(14): 1990–2000. Published online 2013 May 14. doi: 10.1038/emboj.2013.110

PMCID:: PMC3715854

Article PDF–1.7M

Select item 8709312.

The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development

Dónal O'Carroll, Sylvia Erhardt, Michaela Pagani, Sheila C. Barton, M. Azim Surani, Thomas Jenuwein

Mol Cell Biol. 2001 Jul; 21(13): 4330–4336. doi: 10.1128/MCB.21.13.4330-4336.2001

PMCID:: PMC87093

Article PDF–928K

Select item 672654713.

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Zhimin Gu, Yuxuan Liu, Feng Cai, McKenzie Patrick, Jakub Zmajkovic, Hui Cao, Yuannyu Zhang, Alpaslan Tasdogan, Mingyi Chen, Le Qi, Xin Liu, Kailong Li, Junhua Lyu, Kathryn E. Dickerson, Weina Chen, Min Ni, Matthew E. Merritt, Sean J. Morrison, Radek C. Skoda, Ralph J. DeBerardinis, Jian Xu

Cancer Discov. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Cancer Discov. 2019 Sep; 9(9): 1228–1247. Published online 2019 Jun 12. doi: 10.1158/2159-8290.CD-19-0152

PMCID:: PMC6726547

Article PDF–4.9M

Select item 441500714.

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

Woo Kyun Bae, Keunsoo Kang, Ji Hoon Yu, Kyung Hyun Yoo, Valentina M. Factor, Kosuke Kaji, Matthias Matter, Snorri Thorgeirsson, Lothar Hennighausen

FASEB J. 2015 May; 29(5): 1653–1662. Published online 2014 Dec 4. doi: 10.1096/fj.14-261537

PMCID:: PMC4415007

Article

Select item 578546115.

Regulation of haematopoietic multipotency by EZH1

Linda T. Vo, Melissa A. Kinney, Xin Liu, Yuannyu Zhang, Jessica Barragan, Patricia M. Sousa, Deepak K. Jha, Areum Han, Marcella Cesana, Zhen Shao, Trista E. North, Stuart H. Orkin, Sergei Doulatov, Jian Xu, George Q. Daley

Nature. Author manuscript; available in PMC 2018 Jul 17.

Published in final edited form as: Nature. 2018 Jan 25; 553(7689): 506–510. Published online 2018 Jan 17. doi: 10.1038/nature25435

PMCID:: PMC5785461

Article PDF–1.7M

Select item 263050216.

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

Xiaohua Shen, Yingchun Liu, Yu-Jung Hsu, Yuko Fujiwara, Jonghwan Kim, Xiaohong Mao, Guo-Cheng Yuan, Stuart H. Orkin

Mol Cell. Author manuscript; available in PMC 2009 May 21.

Published in final edited form as: Mol Cell. 2008 Nov 21; 32(4): 491–502. doi: 10.1016/j.molcel.2008.10.016

PMCID:: PMC2630502

Article PDF–5.1M

Select item 1089933817.

Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles

Christopher T. Rhodes, Dhanya Asokumar, Mira Sohn, Shovan Naskar, Lielle Elisha, Parker Stevenson, Dongjin R. Lee, Yajun Zhang, Pedro P. Rocha, Ryan K. Dale, Soohyun Lee, Timothy J. Petros

Front Cell Neurosci. 2024; 18: 1334244. Published online 2024 Feb 14. doi: 10.3389/fncel.2024.1334244