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Select item 108438011.

Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper

Neurobiol Dis. Author manuscript; available in PMC 2024 Feb 5.

Published in final edited form as: Neurobiol Dis. 2024 Jan; 190: 106359. Published online 2023 Nov 20. doi: 10.1016/j.nbd.2023.106359

PMCID:: PMC10843801

Article PDF–1.2M

Select item 107935732.

Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A

Linus Manubens-Gil, Meritxell Pons-Espinal, Thomas Gener, Inmaculada Ballesteros-Yañez, María Martínez de Lagrán, Mara Dierssen

Cereb Cortex. 2024 Jan; 34(1): bhad431. Published online 2023 Nov 23. doi: 10.1093/cercor/bhad431

PMCID:: PMC10793573

Article PDF–4.2M

Select item 107325243.

Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status

Wenhao Zhang, Shengyi Sun, Qing Wang, Xu Li, Mei Xu, Qian Li, Yiding Zhao, Keli Peng, Chunmeng Yao, Yuna Wang, Ying Chang, Yan Liu, Xudong Wu, Qian Gao, Ling Shuai

Sci Adv. 2023 Dec 22; 9(51): eadi5683. Published online 2023 Dec 20. doi: 10.1126/sciadv.adi5683

PMCID:: PMC10732524

Article PDF–1.6M

Select item 103995364.

Over‐expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice

Guillaume Postic, Jean Solarz, Cécile Loubière, Janany Kandiah, Jaysen Sawmynaden, Frederic Adam, Marie Vilaire, Thibaut Léger, Jean‐Michel Camadro, Daniella Balduino Victorino, Marie‐Claude Potier, Eric Bun, Gautier Moroy, Alexandre Kauskot, Olivier Christophe, Nathalie Janel

J Cell Mol Med. 2023 Aug; 27(15): 2228–2238. Published online 2023 Jul 6. doi: 10.1111/jcmm.17817

PMCID:: PMC10399536

Article PDF–1.3M

Select item 86249835.

Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts

Jared R. Thomas, Kourtney Sloan, Kelsey Cave, Joseph M. Wallace, Randall J. Roper

Genes (Basel) 2021 Nov; 12(11): 1729. Published online 2021 Oct 28. doi: 10.3390/genes12111729

PMCID:: PMC8624983

Article PDF–2.7M

Select item 86212726.

DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis

Rodolphe Dard, Manon Moreau, Estelle Parizot, Farah Ghieh, Leslie Brehier, Nadim Kassis, Valérie Serazin, Antonin Lamaziere, Chrystèle Racine, Nathalie di Clemente, François Vialard, Nathalie Janel

Genes (Basel) 2021 Nov; 12(11): 1800. Published online 2021 Nov 16. doi: 10.3390/genes12111800

PMCID:: PMC8621272

Article PDF–2.5M

Select item 69960207.

Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Nathanael Shing, Suzanna Noy, Frances K. Wiseman, Neil Burgess, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher

Cell Rep. 2020 Jan 28; 30(4): 1152–1163.e4. Published online 2020 Jan 28. doi: 10.1016/j.celrep.2019.12.065

PMCID:: PMC6996020

Article

Select item 67539338.

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome

Juan Arranz, Elisa Balducci, Krisztina Arató, Gentzane Sánchez-Elexpuru, Sònia Najas, Alberto Parras, Elena Rebollo, Isabel Pijuan, lonas Erb, Gaetano Verde, Ignasi Sahun, Maria J. Barallobre, José J. Lucas, Marina P. Sánchez, Susana de la Luna, Maria L. Arbonés

Neurobiol Dis. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Neurobiol Dis. 2019 Jul; 127: 210–222. Published online 2019 Mar 1. doi: 10.1016/j.nbd.2019.02.022

PMCID:: PMC6753933

Article PDF–2.3M

Select item 66017399.

Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex

Marcel Ruiz-Mejias, Maria Martinez de Lagran, Maurizio Mattia, Patricia Castano-Prat, Lorena Perez-Mendez, Laura Ciria-Suarez, Thomas Gener, Belen Sancristobal, Jordi García-Ojalvo, Agnès Gruart, José M. Delgado-García, Maria V. Sanchez-Vives, Mara Dierssen

J Neurosci. 2016 Mar 30; 36(13): 3648–3659. doi: 10.1523/JNEUROSCI.2517-15.2016

PMCID:: PMC6601739

Article PDF–2.6M

Select item 596381010.

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration

Sheona Watson-Scales, Bernadett Kalmar, Eva Lana-Elola, Dorota Gibbins, Federica La Russa, Frances Wiseman, Matthew Williamson, Rachele Saccon, Amy Slender, Anna Olerinyova, Radma Mahmood, Emma Nye, Heather Cater, Sara Wells, Y. Eugene Yu, David L. H. Bennett, Linda Greensmith, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz

PLoS Genet. 2018 May; 14(5): e1007383. Published online 2018 May 10. doi: 10.1371/journal.pgen.1007383

PMCID:: PMC5963810

Article PDF–8.5M

Select item 580955911.

DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives

Fernanda Neumann, Stéphanie Gourdain, Christelle Albac, Alain D. Dekker, Linh Chi Bui, Julien Dairou, Isabelle Schmitz-Afonso, Nathalie Hue, Fernando Rodrigues-Lima, Jean M. Delabar, Marie-Claude Potier, Jean-Pierre Le Caër, David Touboul, Benoît Delatour, Kevin Cariou, Robert H. Dodd

Sci Rep. 2018; 8: 2859. Published online 2018 Feb 12. doi: 10.1038/s41598-018-20984-z

PMCID:: PMC5809559

Article PDF–1.9M

Select item 487841612.

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

Ercument Dirice, Deepika Walpita, Amedeo Vetere, Bennett C. Meier, Sevim Kahraman, Jiang Hu, Vlado Dančík, Sean M. Burns, Tamara J. Gilbert, David E. Olson, Paul A. Clemons, Rohit N. Kulkarni, Bridget K. Wagner

Diabetes. 2016 Jun; 65(6): 1660–1671. Published online 2016 Mar 7. doi: 10.2337/db15-1127

PMCID:: PMC4878416

Article PDF–2.5M

Select item 464150613.

DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model

Nobuhiro Kurabayashi, Minh Dang Nguyen, Kamon Sanada

EMBO Rep. 2015 Nov; 16(11): 1548–1562. Published online 2015 Sep 15. doi: 10.15252/embr.201540374

PMCID:: PMC4641506

Article PDF–3.7M

Select item 461471014.

Genetic dissection of the Down syndrome critical region

Xiaoling Jiang, Chunhong Liu, Tao Yu, Li Zhang, Kai Meng, Zhuo Xing, Pavel V. Belichenko, Alexander M. Kleschevnikov, Annie Pao, Jennifer Peresie, Sarah Wie, William C. Mobley, Y. Eugene Yu

Hum Mol Genet. 2015 Nov 15; 24(22): 6540–6551. Published online 2015 Sep 15. doi: 10.1093/hmg/ddv364

PMCID:: PMC4614710

Article PDF–914K

Select item 415472315.

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

Susana García-Cerro, Paula Martínez, Verónica Vidal, Andrea Corrales, Jesús Flórez, Rebeca Vidal, Noemí Rueda, María L. Arbonés, Carmen Martínez-Cué

PLoS One. 2014; 9(9): e106572. Published online 2014 Sep 4. doi: 10.1371/journal.pone.0106572

PMCID:: PMC4154723

Article PDF–7.3M

Select item 411167716.

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance

Latif Rachdi, Dulanjalee Kariyawasam, Virginie Aïello, Yann Herault, Nathalie Janel, Jean-Maurice Delabar, Michel Polak, Raphaël Scharfmann

Cell Cycle. 2014 Jul 15; 13(14): 2221–2229. Published online 2014 May 28. doi: 10.4161/cc.29250

PMCID:: PMC4111677

Article PDF–5.3M

Select item 395359017.

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene Dyrk1a

Aurore Thomazeau, Olivier Lassalle, Jillian Iafrati, Benoit Souchet, Fayçal Guedj, Nathalie Janel, Pascale Chavis, Jean Delabar, Olivier J. Manzoni

J Neurosci. 2014 Jan 22; 34(4): 1138–1147. doi: 10.1523/JNEUROSCI.2852-13.2014

PMCID:: PMC3953590

Article PDF–1.6M

Select item 354697918.

Dyrk1A Is Dynamically Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome

Gloria Arque, Anna Casanovas, Mara Dierssen

PLoS One. 2013; 8(1): e54285. Published online 2013 Jan 16. doi: 10.1371/journal.pone.0054285

PMCID:: PMC3546979

Article PDF–4.5M

Select item 256193319.

Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome

Jon Ortiz-Abalia, Ignasi Sahún, Xavier Altafaj, Núria Andreu, Xavier Estivill, Mara Dierssen, Cristina Fillat

Am J Hum Genet. 2008 Oct 10; 83(4): 479–488. Published online 2008 Oct 3. doi: 10.1016/j.ajhg.2008.09.010

PMCID:: PMC2561933

Article PDF–929K

Select item 248128020.

Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

Glòria Arqué, Vassiliki Fotaki, David Fernández, María Martínez de Lagrán, Maria L. Arbonés, Mara Dierssen

PLoS One. 2008; 3(7): e2575. Published online 2008 Jul 2. doi: 10.1371/journal.pone.0002575

PMCID:: PMC2481280

Article PDF–526K

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