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Select item 105442011.

DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer

Wenling Li, Hideki Nakano, Wei Fan, Yuanyuan Li, Payel Sil, Keiko Nakano, Fei Zhao, Peer W. Karmaus, Sara A. Grimm, Min Shi, Xin Xu, Ryushin Mizuta, Daisuke Kitamura, Yisong Wan, Michael B. Fessler, Donald N. Cook, Igor Shats, Xiaoling Li, Leping Li

JCI Insight. 2023 Sep 8; 8(17): e168161. Published online 2023 Sep 8. doi: 10.1172/jci.insight.168161

PMCID:: PMC10544201

Article PDF–3.6M

Select item 60413902.

Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA

Thomas Weisenburger, Bettina von Neubeck, Andrea Schneider, Nadja Ebert, Daniel Schreyer, Andreas Acs, Thomas H. Winkler

Front Immunol. 2018; 9: 1551. Published online 2018 Jul 5. doi: 10.3389/fimmu.2018.01551

PMCID:: PMC6041390

Article PDF–3.0M

Select item 102421343.

Targeting NETs using dual-active DNase1 variants

Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath, Maike Frye, Reiner K. Mailer, Manu Beerens, Julian C. Gerwers, Roger J. S. Preston, Jacob Odeberg, Lynn M. Butler, Coen Maas, Evi X. Stavrou, Tobias A. Fuchs, Thomas Renné

Front Immunol. 2023; 14: 1181761. Published online 2023 May 23. doi: 10.3389/fimmu.2023.1181761

PMCID:: PMC10242134

Article PDF–7.6M

Select item 100371114.

Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms

Keenan A. Lacey, Lee Serpas, Sohei Makita, Yueyang Wang, Ali Rashidfarrokhi, Chetna Soni, Sandra Gonzalez, Andre Moreira, Victor J. Torres, Boris Reizis

J Exp Med. 2023 Jun 5; 220(6): e20221086. Published online 2023 Mar 16. doi: 10.1084/jem.20221086

PMCID:: PMC10037111

Article PDF–9.4M

Select item 90897875.

Effects of nucleases on cell-free extrachromosomal circular DNA

Sarah T.K. Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca W.Y. Chan, Stefano Volpi, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Suk Hang Cheng, Danny K.L. Wong, Kathy O. Lui, Peiyong Jiang, K.C. Allen Chan, Rossa W.K. Chiu, Y.M. Dennis Lo

JCI Insight. 2022 Apr 22; 7(8): e156070. Published online 2022 Apr 22. doi: 10.1172/jci.insight.156070

PMCID:: PMC9089787

Article PDF–917K

Select item 76749986.

Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction

Rebecca W.Y. Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T. Hiraki, Lai-Shan Tam, Ali Rashidfarrokhi, Priscilla C.H. Wong, Lydia H.P. Tam, Yueyang Wang, Peiyong Jiang, Alice S.H. Cheng, Wenlei Peng, Diana S.C. Han, Patty P.P. Tse, Pik Ki Lau, Wing-Shan Lee, Alberto Magnasco, Elisa Buti, Vanja Sisirak, Nora AlMutairi, K.C. Allen Chan, Rossa W.K. Chiu, Boris Reizis, Y.M. Dennis Lo

Am J Hum Genet. 2020 Nov 5; 107(5): 882–894. Published online 2020 Oct 5. doi: 10.1016/j.ajhg.2020.09.006

PMCID:: PMC7674998

Article PDF–2.1M

Select item 38464767.

DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis

Ryushin Mizuta, Shinsuke Araki, Makoto Furukawa, Yuki Furukawa, Syota Ebara, Daisuke Shiokawa, Katsuhiko Hayashi, Sei-ichi Tanuma, Daisuke Kitamura

PLoS One. 2013; 8(12): e80223. Published online 2013 Dec 2. doi: 10.1371/journal.pone.0080223

PMCID:: PMC3846476

Article PDF–4.5M

Select item 100306768.

Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus

Marina A. Korn, Marie Steffensen, Carolin Brandl, Dmytro Royzman, Christoph Daniel, Thomas H. Winkler, Lars Nitschke

Front Immunol. 2023; 14: 1095830. Published online 2023 Mar 8. doi: 10.3389/fimmu.2023.1095830

PMCID:: PMC10030676

Article PDF–5.8M

Select item 83239009.

Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris

Lukas Verhülsdonk, Hans Georg Mannherz, Markus Napirei

PLoS One. 2021; 16(7): e0253476. Published online 2021 Jul 30. doi: 10.1371/journal.pone.0253476

PMCID:: PMC8323900

Article PDF–4.0M

Select item 632998610.

Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA

Lee Serpas, Rebecca W. Y. Chan, Peiyong Jiang, Meng Ni, Kun Sun, Ali Rashidfarrokhi, Chetna Soni, Vanja Sisirak, Wing-Shan Lee, Suk Hang Cheng, Wenlei Peng, K. C. Allen Chan, Rossa W. K. Chiu, Boris Reizis, Y. M. Dennis Lo

Proc Natl Acad Sci U S A. 2019 Jan 8; 116(2): 641–649. Published online 2018 Dec 28. doi: 10.1073/pnas.1815031116

PMCID:: PMC6329986

Article PDF–864K

Select item 503081511.

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

Vanja Sisirak, Benjamin Sally, Vivette D’Agati, Wilnelly Martinez-Ortiz, Z. Birsin Özçakar, Joseph David, Ali Rashidfarrokhi, Ada Yeste, Casandra Panea, Asiya Seema Chida, Milena Bogunovic, Ivaylo I. Ivanov, Francisco J. Quintana, Inaki Sanz, Keith B. Elkon, Mustafa Tekin, Fatos Yalçinkaya, Timothy J. Cardozo, Robert M. Clancy, Jill P. Buyon, Boris Reizis

Cell. Author manuscript; available in PMC 2017 Jun 30.

Published in final edited form as: Cell. 2016 Jun 30; 166(1): 88–101. Published online 2016 Jun 9. doi: 10.1016/j.cell.2016.05.034

PMCID:: PMC5030815

Article PDF–2.4M

Select item 117511212.

Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3)

Markus Napirei, Swantje Wulf, Dirk Eulitz, Hans Georg Mannherz, Thomas Kloeckl

Biochem J. 2005 Jul 15; 389(Pt 2): 355–364. Prepublished online 2005 Mar 30. Published online 2005 Jul 5. doi: 10.1042/BJ20042124

PMCID:: PMC1175112

Article PDF–916K

Select item 802071813.

Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus

Johannes Hartl, Lee Serpas, Yueyang Wang, Ali Rashidfarrokhi, Oriana A. Perez, Benjamin Sally, Vanja Sisirak, Chetna Soni, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Ivan Caiello, Claudia Bracaglia, Stefano Volpi, Gian Marco Ghiggeri, Asiya Seema Chida, Ignacio Sanz, Mimi Y. Kim, H. Michael Belmont, Gregg J. Silverman, Robert M. Clancy, Peter M. Izmirly, Jill P. Buyon, Boris Reizis

J Exp Med. 2021 May 3; 218(5): e20201138. Published online 2021 Mar 30. doi: 10.1084/jem.20201138

PMCID:: PMC8020718

Article PDF–4.6M

Select item 730600214.

Plasmacytoid dendritic cells and type I interferon promote extrafollicular B cell responses to extracellular self-DNA

Chetna Soni, Oriana A. Perez, William N. Voss, Joseph N. Pucella, Lee Serpas, Justin Mehl, Krystal L. Ching, Jule Goike, George Georgiou, Gregory C. Ippolito, Vanja Sisirak, Boris Reizis

Immunity. Author manuscript; available in PMC 2021 Jun 16.

Published in final edited form as: Immunity. 2020 Jun 16; 52(6): 1022–1038.e7. Published online 2020 May 25. doi: 10.1016/j.immuni.2020.04.015

PMCID:: PMC7306002

Article PDF–3.5M

Select item 1683315.

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, Minoru S. H. Ko

Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16): 9127–9132. doi: 10.1073/pnas.97.16.9127

PMCID:: PMC16833

Article PDF–847K

Select item 1091766016.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Article PDF–1.1M

Select item 302253418.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Article PDF–3.8M

Select item 52892819.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Article PDF–140K

Select item 31099220.

RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer

Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki

Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600

PMCID:: PMC310992

Article PDF–3.4M

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