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Select item 82373601.

Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression

Eveline Bruinstroop, Jin Zhou, Madhulika Tripathi, Winifred W. Yau, Anita Boelen, Brijesh Kumar Singh, Paul M. Yen

Mol Metab. 2021 Nov; 53: 101266. Published online 2021 Jun 5. doi: 10.1016/j.molmet.2021.101266

PMCID:: PMC8237360

Abstract Article PDF–1.5M

Select item 102536212.

Chronic Exposure to Chlorpyrifos Damages Thyroid Activity and Imbalances Hepatic Thyroid Hormones Signaling and Glucose Metabolism: Dependency of T3-FOXO1 Axis by Hyperglycemia

Teresa Peluso, Valeria Nittoli, Carla Reale, Immacolata Porreca, Filomena Russo, Luca Roberto, Antonia Giacco, Elena Silvestri, Massimo Mallardo, Mario De Felice, Concetta Ambrosino

Int J Mol Sci. 2023 Jun; 24(11): 9582. Published online 2023 May 31. doi: 10.3390/ijms24119582

PMCID:: PMC10253621

Abstract Article PDF–2.5M

Select item 78912003.

Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism

Monica M. França, Alina German, Gustavo W. Fernandes, Xiao-Hui Liao, Antonio C. Bianco, Samuel Refetoff, Alexandra M. Dumitrescu

Thyroid. February 2021; 31(2): 202–207. Published online 2021 Feb 12. doi: 10.1089/thy.2020.0253

PMCID:: PMC7891200

Abstract Article PDF–377K

Select item 43614104.

Adult Mice Lacking the Type 2 Iodothyronine Deiodinase Have Increased Subchondral Bone but Normal Articular Cartilage

Julian A. Waung, J.H. Duncan Bassett, Graham R. Williams

Thyroid. 2015 Mar 1; 25(3): 269–277. doi: 10.1089/thy.2014.0476

PMCID:: PMC4361410

Abstract Article PDF–1015K

Select item 38360735.

Mct8-Deficient Mice Have Increased Energy Expenditure and Reduced Fat Mass That Is Abrogated by Normalization of Serum T₃ Levels

Caterina Di Cosmo, Xiao-Hui Liao, Honggang Ye, Alfonso Massimiliano Ferrara, Roy E. Weiss, Samuel Refetoff, Alexandra M. Dumitrescu

Endocrinology. 2013 Dec; 154(12): 4885–4895. Published online 2013 Sep 12. doi: 10.1210/en.2013-1150

PMCID:: PMC3836073

Abstract Article

Select item 28677136.

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

J. H. Duncan Bassett, Alan Boyde, Peter G. T. Howell, Richard H. Bassett, Thomas M. Galliford, Marta Archanco, Holly Evans, Michelle A. Lawson, Peter Croucher, Donald L. St. Germain, Valerie Anne Galton, Graham R. Williams

Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16): 7604–7609. Published online 2010 Apr 5. doi: 10.1073/pnas.0911346107

PMCID:: PMC2867713

Abstract Article PDF–1.1M

Select item 26898017.

Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

Valerie Anne Galton, Mark J. Schneider, Ann S. Clark, Donald L. St. Germain

Endocrinology. 2009 Jun; 150(6): 2957–2963. Published online 2009 Feb 5. doi: 10.1210/en.2008-1572

PMCID:: PMC2689801

Abstract Article

Select item 56596738.

An Essential Physiological Role for MCT8 in Bone in Male Mice

Victoria D. Leitch, Caterina Di Cosmo, Xiao-Hui Liao, Sam O’Boy, Thomas M. Galliford, Holly Evans, Peter I. Croucher, Alan Boyde, Alexandra Dumitrescu, Roy E. Weiss, Samuel Refetoff, Graham R. Williams, J. H. Duncan Bassett

Endocrinology. 2017 Sep 1; 158(9): 3055–3066. Published online 2017 Jun 15. doi: 10.1210/en.2017-00399

PMCID:: PMC5659673

Abstract Article

Select item 41649249.

Life Without the Iodothyronine Deiodinases

Valerie Anne Galton, Ellis de Waard, Albert F. Parlow, Donald L. St Germain, Arturo Hernandez

Endocrinology. 2014 Oct; 155(10): 4081–4087. Published online 2014 Jun 20. doi: 10.1210/en.2014-1184

PMCID:: PMC4164924

Abstract Article

Select item 409799710.

The 5′-Deiodinases Are Not Essential for the Fasting-Induced Decrease in Circulating Thyroid Hormone Levels in Male Mice: Possible Roles for the Type 3 Deiodinase and Tissue Sequestration of Hormone

Valerie Anne Galton, Arturo Hernandez, Donald L. St. Germain

Endocrinology. 2014 Aug; 155(8): 3172–3181. Published online 2014 Mar 17. doi: 10.1210/en.2013-1884

PMCID:: PMC4097997

Abstract Article

Select item 304005711.

Distinct Roles of Deiodinases on the Phenotype of Mct8 Defect: A Comparison of Eight Different Mouse Genotypes

Xiao-Hui Liao, Caterina Di Cosmo, Alexandra M. Dumitrescu, Arturo Hernandez, Jacqueline Van Sande, Donald L. St. Germain, Roy E. Weiss, Valerie Anne Galton, Samuel Refetoff

Endocrinology. 2011 Mar; 152(3): 1180–1191. Published online 2011 Feb 1. doi: 10.1210/en.2010-0900

PMCID:: PMC3040057

Abstract Article

Select item 491921912.

Type 1 Deiodinase Regulates ApoA-I Gene Expression and ApoA-I Synthesis Independent of Thyroid Hormone Signaling

Jing Liu, Antonio Hernandez-Ono, Mark J. Graham, Valerie Anne Galton, Henry N. Ginsberg

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Jul; 36(7): 1356–1366. Published online 2016 May 5. doi: 10.1161/ATVBAHA.116.307330

PMCID:: PMC4919219

Abstract Article PDF–950K

Select item 560240113.

De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone

Cintia E. Citterio, Balaji Veluswamy, Sarah J. Morgan, Valerie A. Galton, J. Paul Banga, Stephen Atkins, Yoshiaki Morishita, Susanne Neumann, Rauf Latif, Marvin C. Gershengorn, Terry J. Smith, Peter Arvan

J Biol Chem. 2017 Sep 15; 292(37): 15434–15444. Published online 2017 Jul 25. doi: 10.1074/jbc.M117.784447

PMCID:: PMC5602401

Abstract Article PDF–2.0M

Select item 242312614.

Hepatocyte Nuclear Factor 4α Contributes to Thyroid Hormone Homeostasis by Cooperatively Regulating the Type 1 Iodothyronine Deiodinase Gene with GATA4 and Krüppel-Like Transcription Factor 9

Hiroto Ohguchi, Toshiya Tanaka, Aoi Uchida, Kenta Magoori, Hiromi Kudo, Insook Kim, Kenji Daigo, Iori Sakakibara, Masashi Okamura, Hideo Harigae, Takeshi Sasaki, Timothy F. Osborne, Frank J. Gonzalez, Takao Hamakubo, Tatsuhiko Kodama, Juro Sakai

Mol Cell Biol. 2008 Jun; 28(12): 3917–3931. Published online 2008 Apr 21. doi: 10.1128/MCB.02154-07

PMCID:: PMC2423126

Abstract Article PDF–1.4M

Select item 108429115.

The Distal Sequence Element of the Selenocysteine tRNA Gene Is a Tissue-Dependent Enhancer Essential for Mouse Embryogenesis

Vincent P. Kelly, Takafumi Suzuki, Osamu Nakajima, Tsuyoshi Arai, Yoshitaka Tamai, Satoru Takahashi, Susumu Nishimura, Masayuki Yamamoto

Mol Cell Biol. 2005 May; 25(9): 3658–3669. doi: 10.1128/MCB.25.9.3658-3669.2005

PMCID:: PMC1084291

Abstract Article PDF–598K

Select item 541739416.

The Thyroid Hormone Receptor α1 Protein Is Expressed in Embryonic Postmitotic Neurons and Persists in Most Adult Neurons

Karin Wallis, Susi Dudazy, Max van Hogerlinden, Kristina Nordström, Jens Mittag, Björn Vennström

Mol Endocrinol. October 1, 2010; 24(10): 1904–1916. doi: 10.1210/me.2010-0175

PMCID:: PMC5417394

Abstract Article

Select item 28829817.

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.

M J Berry, D Grieco, B A Taylor, A L Maia, J D Kieffer, W Beamer, E Glover, A Poland, P R Larsen

J Clin Invest. 1993 Sep; 92(3): 1517–1528. doi: 10.1172/JCI116730

PMCID:: PMC288298

Summary Page Browse PDF–2.3M

Select item 967555618.

DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities

M. Elena Martinez, Ilka Pinz, Marilena Preda, Christine R. Norton, Thomas Gridley, Arturo Hernandez

JCI Insight. 2022 Nov 8; 7(21): e161214. Published online 2022 Nov 8. doi: 10.1172/jci.insight.161214

PMCID:: PMC9675556

Abstract Article PDF–3.9M

Select item 8596619.

Hepatocyte Nuclear Factor 3β (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte

Newman J. Sund, Siew-Lan Ang, Sara Dutton Sackett, Wei Shen, Nathalie Daigle, Mark A. Magnuson, Klaus H. Kaestner

Mol Cell Biol. 2000 Jul; 20(14): 5175–5183. doi: 10.1128/mcb.20.14.5175-5183.2000

PMCID:: PMC85966

Abstract Article PDF–2.8M

Select item 368927920.

Changes in Thyroid Status During Perinatal Development of MCT8-Deficient Male Mice

Alfonso Massimiliano Ferrara, Xiao-Hui Liao, Pilar Gil-Ibáñez, Teresa Marcinkowski, Juan Bernal, Roy E. Weiss, Alexandra M. Dumitrescu, Samuel Refetoff

Endocrinology. 2013 Jul; 154(7): 2533–2541. Published online 2013 May 21. doi: 10.1210/en.2012-2031