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Items: 1 to 20 of 51

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
2.
Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection
Soo Jung Cho, Alexander Pronko, Jianjun Yang, Kassandra Pagan, Heather Stout-Delgado
Cells. 2023 Feb; 12(4): 570. Published online 2023 Feb 10. doi: 10.3390/cells12040570
PMCID:
PMC9953875
ArticlePDF–2.1M
3.
Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin
Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Akiko Kubo, Koichi Isami, Yohei Mikami, Miho Mukai, Takashi Sasaki, Jun Yamagami, Jun Kudoh, Hiromi Ito, Aki Kamata, Yutaka Kurebayashi, Hiroki Yoshida, Akihiko Yoshimura, Hong-Wei Sun, Makoto Suematsu, Jonh J. O’Shea, Yuka Kanno, Masayuki Amagai
Sci Immunol. Author manuscript; available in PMC 2022 Dec 23.
Published in final edited form as: Sci Immunol. 2021 Oct 15; 6(64): eabb6444. Published online 2021 Oct 8. doi: 10.1126/sciimmunol.abb6444
PMCID:
PMC9780739
ArticlePDF–2.3M
4.
A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol
Yukitoshi Izumi, Anil G. Cashikar, Kathiresan Krishnan, Steven M. Paul, Douglas F. Covey, Steven J. Mennerick, Charles F. Zorumski
J Neurosci. 2021 Dec 8; 41(49): 10054–10064. doi: 10.1523/JNEUROSCI.1502-21.2021
PMCID:
PMC8660051
ArticlePDF–1.9M
5.
Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway
Swechha M. Pokharel, Kim Chiok, Niraj K. Shil, Indira Mohanty, Santanu Bose
PLoS One. 2021; 16(9): e0257576. Published online 2021 Sep 22. doi: 10.1371/journal.pone.0257576
PMCID:
PMC8457477
ArticlePDF–1.5M
6.
Regulation of intercellular biomolecule transfer–driven tumor angiogenesis and responses to anticancer therapies
Zhen Lu, Angelica Ortiz, Ioannis I. Verginadis, Amy R. Peck, Farima Zahedi, Christina Cho, Pengfei Yu, Rachel M. DeRita, Hongru Zhang, Ryan Kubanoff, Yunguang Sun, Andrew T. Yaspan, Elise Krespan, Daniel P. Beiting, Enrico Radaelli, Sandra W. Ryeom, J. Alan Diehl, Hallgeir Rui, Constantinos Koumenis, Serge Y. Fuchs
J Clin Invest. 2021 May 17; 131(10): e144225. Published online 2021 May 17. doi: 10.1172/JCI144225
PMCID:
PMC8121529
ArticlePDF–9.0M
7.
Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function
Na Sheng, Zhongnan Ma, Yi Zhou, Juan Xu, Yan Gao, Xin-Yuan Fu
Sci Rep. 2020; 10: 14246. Published online 2020 Aug 28. doi: 10.1038/s41598-020-71198-1
PMCID:
PMC7455728
ArticlePDF–6.8M
8.
Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation
Jennifer H. Madenspacher, Eric D. Morrell, Kymberly M. Gowdy, Jeffrey G. McDonald, Bonne M. Thompson, Ginger Muse, Jennifer Martinez, Seddon Thomas, Carmen Mikacenic, Jerry A. Nick, Edward Abraham, Stavros Garantziotis, Renee D. Stapleton, Julie M. Meacham, Mary Jane Thomassen, William J. Janssen, Donald N. Cook, Mark M. Wurfel, Michael B. Fessler
JCI Insight. 2020 Jun 4; 5(11): e137189. Published online 2020 Jun 4. doi: 10.1172/jci.insight.137189
PMCID:
PMC7308063
ArticlePDF–5.7M
9.
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice
Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner
J Diabetes Res. 2017; 2017: 4108768. Published online 2017 Feb 19. doi: 10.1155/2017/4108768
PMCID:
PMC5337352
ArticlePDF–1008K
10.
25-hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
Andrea Reboldi, Eric V. Dang, Jeffrey G. McDonald, Guosheng Liang, David W. Russell, Jason G. Cyster
Science. Author manuscript; available in PMC 2015 Feb 8.
Published in final edited form as: Science. 2014 Aug 8; 345(6197): 679–684. doi: 10.1126/science.1254790
PMCID:
PMC4289637
ArticlePDF–942K
11.
Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol
Su-Yang Liu, Roghiyh Aliyari, Kelechi Chikere, Guangming Li, Matthew D. Marsden, Jennifer K. Smith, Olivier Pernet, Haitao Guo, Rebecca Nusbaum, Jerome A. Zack, Alexander N. Freiberg, Lishan Su, Benhur Lee, Genhong Cheng
Immunity. Author manuscript; available in PMC 2013 Jul 2.
Published in final edited form as: Immunity. 2013 Jan 24; 38(1): 92–105. Published online 2012 Dec 27. doi: 10.1016/j.immuni.2012.11.005
PMCID:
PMC3698975
ArticlePDF–5.2M
12.
Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages
Tie Zou, Oleg Garifulin, Robert Berland, Victor L. Boyartchuk
Infect Immun. 2011 Apr; 79(4): 1526–1535. Published online 2011 Jan 24. doi: 10.1128/IAI.01195-10
PMCID:
PMC3067555
ArticlePDF–1.6M
13.
Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice
Michael B. Fessler, Jennifer H. Madenspacher, Paul J. Baker, Kerry L. Hilligan, Andrea C. Bohrer, Ehydel Castro, Julie Meacham, Shih-Heng Chen, Reed F. Johnson, Jeffrey G. McDonald, Negin P. Martin, Charles J. Tucker, Debabrata Mahapatra, Mark Cesta, Katrin D. Mayer-Barber
Am J Respir Cell Mol Biol. 2023 Dec 1; 69(6): 638–648. Published online 2023 Aug 14. doi: 10.1165/rcmb.2023-0007OC
PMCID:
PMC10704115
ArticlePDF–1.6M
14.
Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer
Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs
Nat Commun. 2022; 13: 6623. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34428-w
PMCID:
PMC9636202
ArticlePDF–6.2M
15.
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes
Lucia Russo, Lindsey Muir, Lynn Geletka, Jennifer Delproposto, Nicki Baker, Carmen Flesher, Robert O'Rourke, Carey N. Lumeng
Mol Metab. 2020 Sep; 39: 100983. Published online 2020 Mar 27. doi: 10.1016/j.molmet.2020.100983
PMCID:
PMC7267735
ArticlePDF–3.6M
16.
Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis
Tina Raselli, Tom Hearn, Annika Wyss, Kirstin Atrott, Alain Peter, Isabelle Frey-Wagner, Marianne R. Spalinger, Ewerton M. Maggio, Andreas W. Sailer, Johannes Schmitt, Philipp Schreiner, Anja Moncsek, Joachim Mertens, Michael Scharl, William J. Griffiths, Marco Bueter, Andreas Geier, Gerhard Rogler, Yuqin Wang, Benjamin Misselwitz
J Lipid Res. 2019 Jul; 60(7): 1270–1283. Published online 2019 May 21. doi: 10.1194/jlr.M093229
PMCID:
PMC6602130
ArticlePDF–1.9M
17.
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
Ulf Diczfalusy, Katarina E. Olofsson, Ann-Margreth Carlsson, Mei Gong, Douglas T. Golenbock, Olav Rooyackers, Urban Fläring, Harry Björkbacka
J Lipid Res. 2009 Nov; 50(11): 2258–2264. doi: 10.1194/jlr.M900107-JLR200
PMCID:
PMC2759831
ArticlePDF–740K
18.
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
David R. Bauman, Andrew D. Bitmansour, Jeffrey G. McDonald, Bonne M. Thompson, Guosheng Liang, David W. Russell
Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39): 16764–16769. Published online 2009 Sep 15. doi: 10.1073/pnas.0909142106
PMCID:
PMC2757821
ArticlePDF–455K
19.
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes
Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs
Cell Metab. Author manuscript; available in PMC 2023 Sep 12.
Published in final edited form as: Cell Metab. 2022 Sep 6; 34(9): 1342–1358.e7. doi: 10.1016/j.cmet.2022.08.007
Correction in:
Cell Metab. 2024 Apr 10
PMCID:
PMC10496461
ArticlePDF–3.6M
20.
Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response
Swechha M. Pokharel, Niraj K. Shil, Jeevan B. GC, Zachary T. Colburn, Su-Yu Tsai, Jesus A. Segovia, Te-Hung Chang, Smarajit Bandyopadhyay, Senthil Natesan, Jonathan C. R. Jones, Santanu Bose
Nat Commun. 2019; 10: 1482. Published online 2019 Apr 1. doi: 10.1038/s41467-019-09453-x
PMCID:
PMC6443809
ArticlePDF–2.5M

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