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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 105723322.

c-Cbl Regulates Murine Subventricular Zone-Derived Neural Progenitor Cells in Dependence of the Epidermal Growth Factor Receptor

Maximilian Vogt, Madhukrishna Kolothara Unnikrishnan, Nora Heinig, Ulrike Schumann, Mirko H. H. Schmidt, Kathrin Barth

Cells. 2023 Oct; 12(19): 2400. Published online 2023 Oct 3. doi: 10.3390/cells12192400

PMCID:: PMC10572332

Article PDF–5.9M

Select item 94355903.

Hematopoietic Stem/Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR-and CDK1-dependent Mechanisms

Christina C. Spevak, Harold K. Elias, Lavanya Kannan, Mohamed A.E. Ali, Gaëlle H. Martin, Shanmugapriya Selvaraj, William S. Eng, Amanda Ernlund, Vinagolu K. Rajasekhar, Carolien M. Woolthuis, Guangjie Zhao, Caryn J. Ha, Robert J. Schneider, Christopher Y. Park

Cell Stem Cell. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Cell Stem Cell. 2020 May 7; 26(5): 755–765.e7. doi: 10.1016/j.stem.2019.12.006

PMCID:: PMC9435590

Article PDF–1.6M

Select item 83363014.

C-CBL is required for inhibition of angiogenesis through modulating JAK2/STAT3 activity in ROP development

Shimei Chen, Qiao Sun, Dandan Sun, Jami Willette-Brown, Matthew J. Anderson, Qing Gu, Mark Lewandoski, Yinling Hu, Feng Zhu, Fang Wei, Jian Zhang

Biomed Pharmacother. Author manuscript; available in PMC 2021 Aug 4.

Published in final edited form as: Biomed Pharmacother. 2020 Dec; 132: 110856. Published online 2020 Oct 28. doi: 10.1016/j.biopha.2020.110856

PMCID:: PMC8336301

Article PDF–1.0M

Select item 64928645.

The E3 Ubiquitin Ligase c‐Cbl Inhibits Microglia‐Mediated CNS Inflammation by Regulating PI3K/Akt/NF‐κB Pathway

Lin Dong, Yu‐Zhen Li, Hai‐Ting An, Ya‐Long Wang, Shi‐Hao Chen, Yan‐Jing Qian, Ke Wang, Jun‐Li Zhen, Zheng Fan, Xiao‐Li Gong, Yan Zheng, Xiao‐Min Wang

CNS Neurosci Ther. 2016 Aug; 22(8): 661–669. Published online 2016 May 9. doi: 10.1111/cns.12557

PMCID:: PMC6492864

Article PDF–2.3M

Select item 53916216.

Acquired expression of Cbl^Q367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia

Yuichiro Nakata, Takeshi Ueda, Akiko Nagamachi, Norimasa Yamasaki, Ken-ichiro Ikeda, Yasuyuki Sera, Keiyo Takubo, Akinori Kanai, Hideaki Oda, Masashi Sanada, Seishi Ogawa, Kohichiro Tsuji, Yasuhiro Ebihara, Linda Wolff, Zen-ichiro Honda, Toshio Suda, Toshiya Inaba, Hiroaki Honda

Blood. 2017 Apr 13; 129(15): 2148–2160. Prepublished online 2017 Feb 16. doi: 10.1182/blood-2016-06-724658

PMCID:: PMC5391621

Article

Select item 45789227.

Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair

Vanessa Scanlon, Do Yu Soung, Naga Suresh Adapala, Elise Morgan, Marc F. Hansen, Hicham Drissi, Archana Sanjay

PLoS One. 2015; 10(9): e0138194. Published online 2015 Sep 22. doi: 10.1371/journal.pone.0138194

PMCID:: PMC4578922

Article PDF–15M

Select item 45466188.

Casitas B-Lineage Lymphoma RING Domain Inhibitors Protect Mice against High-Fat Diet-Induced Obesity and Insulin Resistance

Min Wu, Lin Sun, Ziyan Yuan Pessetto, Zhihe Zang, Xingliang Xie, Ling Zhong, Qing Su, Wang Zan, Xiurong Gao, Yan Zhao, Yiyi Sun

PLoS One. 2015; 10(8): e0135916. Published online 2015 Aug 21. doi: 10.1371/journal.pone.0135916

PMCID:: PMC4546618

Article PDF–1.5M

Select item 39818169.

Dasatinib Targets B-Lineage Cells but Does Not Provide an Effective Therapy for Myeloproliferative Disease in c-Cbl RING Finger Mutant Mice

Johanna M. Duyvestyn, Samuel J. Taylor, Samantha A. Dagger, Marlene Orandle, Herbert C. Morse, III, Christine B. F. Thien, Wallace Y. Langdon

PLoS One. 2014; 9(4): e94717. Published online 2014 Apr 9. doi: 10.1371/journal.pone.0094717

PMCID:: PMC3981816

Article PDF–2.0M

Select item 338608110.

Templates are available to model nearly all complexes of structurally characterized proteins

Petras J. Kundrotas, Zhengwei Zhu, Joël Janin, Ilya A. Vakser

Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24): 9438-9441. Published online 2012 May 29. doi: 10.1073/pnas.1200678109

PMCID:: PMC3386081

Article PDF–965K

Select item 297860311.

The Loss of Cbl-Phosphatidylinositol 3-Kinase Interaction Perturbs RANKL-mediated Signaling, Inhibiting Bone Resorption and Promoting Osteoclast Survival

Naga Suresh Adapala, Mary F. Barbe, Wallace Y. Langdon, Mary C. Nakamura, Alexander Y. Tsygankov, Archana Sanjay

J Biol Chem. 2010 Nov 19; 285(47): 36745–36758. Published online 2010 Sep 17. doi: 10.1074/jbc.M110.124628

PMCID:: PMC2978603

Article PDF–2.9M

Select item 284378212.

Anergic CD4⁺ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b

Melissa Doherty, Douglas G. Osborne, Diana L. Browning, David C. Parker, Scott A. Wetzel

J Immunol. Author manuscript; available in PMC 2011 Apr 1.

Published in final edited form as: J Immunol. 2010 Apr 1; 184(7): 3598–3608. Published online 2010 Mar 5. doi: 10.4049/jimmunol.0902285

PMCID:: PMC2843782

Article PDF–2.7M

Select item 233533113.

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells

Chozhavendan Rathinam, Christine B.F. Thien, Wallace Y. Langdon, Hua Gu, Richard A. Flavell

Genes Dev. 2008 Apr 15; 22(8): 992–997. doi: 10.1101/gad.1651408

Correction in:: Genes Dev. 2009 Sep 1; 23(17): 2116.

PMCID:: PMC2335331

Article PDF–371K

Select item 219386514.

A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine Kinase

Christine B.F. Thien, Robin M. Scaife, John M. Papadimitriou, Maria A. Murphy, David D.L. Bowtell, Wallace Y. Langdon

J Exp Med. 2003 Feb 17; 197(4): 503–513. doi: 10.1084/jem.20021498

PMCID:: PMC2193865

Article PDF–414K

Select item 127672315.

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion

Christine B F Thien, Frøydis D Blystad, Yifan Zhan, Andrew M Lew, Valentina Voigt, Christopher E Andoniou, Wallace Y Langdon

EMBO J. 2005 Nov 2; 24(21): 3807–3819. Published online 2005 Oct 6. doi: 10.1038/sj.emboj.7600841

PMCID:: PMC1276723

Article PDF–638K

Select item 117144016.

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation.

P S Lee, Y Wang, M G Dominguez, Y G Yeung, M A Murphy, D D Bowtell, E R Stanley

EMBO J. 1999 Jul 1; 18(13): 3616–3628. doi: 10.1093/emboj/18.13.3616

PMCID:: PMC1171440

Summary PDF–577K

Select item 52422717.

c-Cbl–deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

Juan C. Molero, Thomas E. Jensen, Phil C. Withers, Michelle Couzens, Herbert Herzog, Christine B.F. Thien, Wallace Y. Langdon, Ken Walder, Maria A. Murphy, David D.L. Bowtell, David E. James, Gregory J. Cooney

J Clin Invest. 2004 Nov 1; 114(9): 1326–1333. doi: 10.1172/JCI21480

Correction in:: J Clin Invest. 2005 Feb 1; 115(2): 476.

PMCID:: PMC524227

Article PDF–522K

Select item 28664718.

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

W Y Langdon, J W Hartley, S P Klinken, S K Ruscetti, H C Morse, 3rd

Proc Natl Acad Sci U S A. 1989 Feb; 86(4): 1168–1172. doi: 10.1073/pnas.86.4.1168

PMCID:: PMC286647

Summary Page Browse PDF–1.2M

Select item 10907219.

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

Maria A. Murphy, Ralf G. Schnall, Deon J. Venter, Louise Barnett, Ivan Bertoncello, Christine B. F. Thien, Wallace Y. Langdon, David D. L. Bowtell

Mol Cell Biol. 1998 Aug; 18(8): 4872–4882. doi: 10.1128/mcb.18.8.4872

PMCID:: PMC109072

Article PDF–2.2M

Select item 996474020.

CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells

Cho-Cho Aye, Dean E. Hammond, Sergio Rodriguez-Cuenca, Mary K. Doherty, Phillip D. Whitfield, Marie M. Phelan, Chenjing Yang, Rafael Perez-Perez, Xiaoxin Li, Angels Diaz-Ramos, Gopal Peddinti, Matej Oresic, Antonio Vidal-Puig, Antonio Zorzano, Cristina Ugalde, Silvia Mora

Int J Mol Sci. 2023 Feb; 24(4): 3399. Published online 2023 Feb 8. doi: 10.3390/ijms24043399

PMCID:: PMC9964740

Article PDF–2.4M

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