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Items: 1 to 20 of 118

1.
Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism
Pedro Rodriguez, Lauren J. Laskowski, Jean Pierre Pallais, Hailey A. Bock, Natalie G. Cavalco, Emilie I. Anderson, Maggie M. Calkins, Maria Razzoli, Yuk Y. Sham, John D. McCorvy, Alessandro Bartolomucci
J Biol Chem. 2024 Jan; 300(1): 105549. Published online 2023 Dec 10. doi: 10.1016/j.jbc.2023.105549
PMCID:
PMC10796979
AbstractArticlePDF–2.2M
2.
Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology
Manasee Gedam, Michele M. Comerota, Nicholas E. Propson, Tao Chen, Feng Jin, Meng C. Wang, Hui Zheng
J Clin Invest. 2023 Jun 15; 133(12): e167501. Published online 2023 Jun 15. doi: 10.1172/JCI167501
PMCID:
PMC10266793
AbstractArticlePDF–18M
3.
C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models
Saravanan Nandagopal, Caiyun G. Li, Yu Xu, Quaovi H. Sodji, Edward E. Graves, Amato J. Giaccia
Cancer Immunol Res. Author manuscript; available in PMC 2022 Aug 4.
Published in final edited form as: Cancer Immunol Res. 2022 Feb; 10(2): 245–258. Published online 2021 Nov 24. doi: 10.1158/2326-6066.CIR-21-0435
PMCID:
PMC9351714
AbstractArticlePDF–1.8M
4.
C3a Receptor Signaling Inhibits Neurodegeneration Induced by Neonatal Hypoxic-Ischemic Brain Injury
Andrea Pozo-Rodrigálvarez, YiXian Li, Anna Stokowska, Jingyun Wu, Verena Dehm, Hana Sourkova, Harry Steinbusch, Carina Mallard, Henrik Hagberg, Milos Pekny, Marcela Pekna
Front Immunol. 2021; 12: 768198. Published online 2021 Dec 17. doi: 10.3389/fimmu.2021.768198
PMCID:
PMC8718687
AbstractArticlePDF–30M
5.
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression
Elena Magrini, Sabrina Di Marco, Sarah N. Mapelli, Chiara Perucchini, Fabio Pasqualini, Alessia Donato, Maria de la Luz Guevara Lopez, Roberta Carriero, Andrea Ponzetta, Piergiuseppe Colombo, Ferdinando Cananzi, Domenico Supino, Edimara S. Reis, Clelia Peano, Antonio Inforzato, Sebastien Jaillon, Andrea Doni, John D. Lambris, Alberto Mantovani, Cecilia Garlanda
Nat Cancer. Author manuscript; available in PMC 2021 Sep 8.
Published in final edited form as: Nat Cancer. 2021 Feb; 2(2): 218–232. Published online 2021 Feb 18. doi: 10.1038/s43018-021-00173-0
PMCID:
PMC8425276
AbstractArticlePDF–5.4M
6.
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging
Nicholas E. Propson, Ethan R. Roy, Alexandra Litvinchuk, Jörg Köhl, Hui Zheng
J Clin Invest. 2021 Jan 4; 131(1): e140966. Published online 2021 Jan 4. doi: 10.1172/JCI140966
PMCID:
PMC7773352
AbstractArticlePDF–4.3M
7.
Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival
Douglas R. Mathern, Julian Horwitz, Peter S. Heeger
Am J Transplant. Author manuscript; available in PMC 2020 Jun 1.
Published in final edited form as: Am J Transplant. 2019 Jun; 19(6): 1628–1640. Published online 2019 Jan 14. doi: 10.1111/ajt.15222
PMCID:
PMC6538425
AbstractArticlePDF–1.8M
8.
C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation
Lalit Kumar, Bao Lu, Craig Gerard, Raif S. Geha
J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Feb 8.
Published in final edited form as: J Allergy Clin Immunol. 2013 Sep; 132(3): 746–748.e3. Published online 2013 May 16. doi: 10.1016/j.jaci.2013.03.041
PMCID:
PMC5805376
ArticlePDF–477K
9.
The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis
Jonathan Dick, Poh-Yi Gan, A. Richard Kitching, Stephen R. Holdsworth
PLoS One. 2018; 13(1): e0190655. Published online 2018 Jan 9. doi: 10.1371/journal.pone.0190655
PMCID:
PMC5760037
AbstractArticlePDF–4.1M
10.
Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling
Suzanne Doolen, Jennifer Cook, Maureen Riedl, Kelley Kitto, Shinichi Kohsaka, Christopher N. Honda, Carolyn A. Fairbanks, Bradley K. Taylor, Lucy Vulchanova
Glia. Author manuscript; available in PMC 2018 Dec 1.
Published in final edited form as: Glia. 2017 Dec; 65(12): 1976–1989. Published online 2017 Aug 29. doi: 10.1002/glia.23208
PMCID:
PMC5747931
AbstractArticlePDF–1.7M
11.
The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization
Mike C. L. Wu, Faith H. Brennan, Jason P. L. Lynch, Susanna Mantovani, Simon Phipps, Rick A. Wetsel, Marc J. Ruitenberg, Stephen M. Taylor, Trent M. Woodruff
Proc Natl Acad Sci U S A. 2013 Jun 4; 110(23): 9439–9444. Published online 2013 May 21. doi: 10.1073/pnas.1218815110
PMCID:
PMC3677481
AbstractArticlePDF–1.0M
12.
The Complement Anaphylatoxin C3a Receptor (C3aR) Contributes to the Inflammatory Response in Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
Elisabeth Wende, Robert Laudeley, André Bleich, Eva Bleich, Rick A. Wetsel, Silke Glage, Andreas Klos
PLoS One. 2013; 8(4): e62257. Published online 2013 Apr 26. doi: 10.1371/journal.pone.0062257
PMCID:
PMC3637373
AbstractArticlePDF–13M
13.
C3aR inhibition reduces neurodegeneration in experimental lupus
A Jacob, L Bao, J Brorson, RJ Quigg, JJ Alexander
Lupus. Author manuscript; available in PMC 2011 Jan 1.
Published in final edited form as: Lupus. 2010 Jan; 19(1): 73–82. Published online 2009 Nov 9. doi: 10.1177/0961203309348978
PMCID:
PMC2952506
AbstractArticlePDF–1.1M
14.
The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation
Yaël Mamane, Chi Chung Chan, Genevieve Lavallee, Nicolas Morin, Li-Jing Xu, JingQi Huang, Robert Gordon, Winston Thomas, John Lamb, Eric E. Schadt, Brian P. Kennedy, Joseph A. Mancini
Diabetes. 2009 Sep; 58(9): 2006–2017. Published online 2009 Jul 6. doi: 10.2337/db09-0323
PMCID:
PMC2731537
AbstractArticlePDF–2.0M
15.
C3a Receptor Deficiency Accelerates the Onset of Renal Injury in the MRL/lpr Mouse
Scott E. Wenderfer, Hongyu Wang, Baozhen Ke, Rick A. Wetsel, Michael C. Braun
Mol Immunol. Author manuscript; available in PMC 2010 Apr 1.
Published in final edited form as: Mol Immunol. 2009 Apr; 46(7): 1397–1404. Published online 2009 Jan 23. doi: 10.1016/j.molimm.2008.12.004
PMCID:
PMC2697606
AbstractArticlePDF–989K
16.
The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen
Seiji Kawamoto, Ali Yalcindag, Dhafer Laouini, Scott Brodeur, Paul Bryce, Bao Lu, Alison A. Humbles, Hans Oettgen, Craig Gerard, Raif S. Geha
J Clin Invest. 2004 Aug 1; 114(3): 399–407. doi: 10.1172/JCI19082
PMCID:
PMC484971
AbstractArticlePDF–401K
17.
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages
Allison Cohen, Edwin E. Jeng, Mark Voorhies, Jane Symington, Nebat Ali, Rosa A. Rodriguez, Michael C. Bassik, Anita Sil
PLoS Pathog. 2022 Sep; 18(9): e1010237. Published online 2022 Sep 29. doi: 10.1371/journal.ppat.1010237
PMCID:
PMC9578593
AbstractArticlePDF–4.3M
18.
The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus
Yujia Wei, Tingjun Chen, Dale B. Bosco, Manling Xie, Jiaying Zheng, Aastha Dheer, Yanlu Ying, Qian Wu, Vanda A. Lennon, Long-Jun Wu
Glia. Author manuscript; available in PMC 2021 May 1.
Published in final edited form as: Glia. 2021 May; 69(5): 1155–1169. Published online 2020 Dec 14. doi: 10.1002/glia.23955
PMCID:
PMC7936954
AbstractArticlePDF–3.6M
19.
Endothelial progenitor cell transplantation alleviated ischemic brain injury via inhibiting C3/C3aR pathway in mice
Yuanyuan Ma, Lu Jiang, Liping Wang, Yongfang Li, Yanqun Liu, Wenjing Lu, Rubing Shi, Linyuan Zhang, Zongjie Fu, Meijie Qu, Yingling Liu, Yongting Wang, Zhijun Zhang, Guo-Yuan Yang
J Cereb Blood Flow Metab. 2020 Dec; 40(12): 2374–2386. Published online 2019 Dec 22. doi: 10.1177/0271678X19892777
PMCID:
PMC7820683
AbstractArticlePDF–1.8M
20.
Complement as Prognostic Biomarker and Potential Therapeutic Target in Renal Cell Carcinoma.
Britney Reese, Ashok Silwal, Elizabeth Daugherity, Michael Daugherity, Mahshid Arabi, Pierce Daly, Yvonne Paterson, Layton Woolford, Alana Christie, Roy Elias, James Brugarolas, Tao Wang, Magdalena Karbowniczek, Maciej M. Markiewski
J Immunol. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: J Immunol. 2020 Dec 1; 205(11): 3218–3229. Published online 2020 Nov 6. doi: 10.4049/jimmunol.2000511
PMCID:
PMC7703597
AbstractArticlePDF–3.2M

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