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Select item 108971641.

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth

Anita Bodac, Abdullah Mayet, Sarika Rana, Justine Pascual, Amber D Bowler, Vincent Roh, Nadine Fournier, Ligia Craciun, Pieter Demetter, Freddy Radtke, Etienne Meylan

EMBO Mol Med. 2024 Jan; 16(1): 158–184. Published online 2023 Dec 20. doi: 10.1038/s44321-023-00013-x

PMCID:: PMC10897164

Article PDF–8.1M

Select item 107435712.

Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis

Takeshi Moriishi, Yosuke Kawai, Ryo Fukuyama, Yuki Matsuo, You-Wen He, Haruhiko Akiyama, Izumi Asahina, Toshihisa Komori

Int J Mol Sci. 2023 Dec; 24(24): 17319. Published online 2023 Dec 10. doi: 10.3390/ijms242417319

PMCID:: PMC10743571

Article PDF–3.7M

Select item 105092653.

Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice

Michinari Nakamura, Mariko Aoyagi Keller, Nadezhda Fefelova, Peiyong Zhai, Tong Liu, Yimin Tian, Shohei Ikeda, Dominic P. Del Re, Hong Li, Lai-Hua Xie, Junichi Sadoshima

Nat Commun. 2023; 14: 5805. Published online 2023 Sep 19. doi: 10.1038/s41467-023-41595-x

PMCID:: PMC10509265

Article PDF–5.8M

Select item 98083744.

Bcl-xL Is a Key Mediator of Apoptosis Following KRAS^G12C Inhibition in KRAS^G12C-mutant Colorectal Cancer

Hajrah Khawaja, Rebecca Briggs, Cheryl H. Latimer, Mustasin Rassel, Daryl Griffin, Lyndsey Hanson, Alberto Bardelli, Frederica Di Nicolantonio, Simon S. McDade, Christopher J. Scott, Shauna Lambe, Manisha Maurya, Andreas U. Lindner, Jochen H.M. Prehn, Jose Sousa, Chris Winnington, Melissa J. LaBonte, Sarah Ross, Sandra Van Schaeybroeck

Mol Cancer Ther. 2023 Jan 3; 22(1): 135–149. Published online 2022 Oct 22. doi: 10.1158/1535-7163.MCT-22-0301

PMCID:: PMC9808374

Article PDF–16M

Select item 80503025.

Malignant pleural mesothelioma co-opts BCL-X_L and autophagy to escape apoptosis

Duo Xu, Shun-Qing Liang, Zhang Yang, Haitang Yang, Rémy Bruggmann, Simone Oberhaensli, Sabina Berezowska, Thomas M. Marti, Sean R. R. Hall, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng

Cell Death Dis. 2021 Apr; 12(4): 406. Published online 2021 Apr 15. doi: 10.1038/s41419-021-03668-x

PMCID:: PMC8050302

Article PDF–3.2M

Select item 67298266.

Enhanced In Vitro Midbrain Dopamine Neuron Differentiation, Dopaminergic Function, Neurite Outgrowth, and 1-Methyl-4-Phenylpyridium Resistance in Mouse Embryonic Stem Cells Overexpressing Bcl-XL

Jae-Won Shim, Hyun-Chul Koh, Mi-Yoon Chang, Eun Roh, Cha-Yong Choi, Young J. Oh, Hyeon Son, Yong-Sung Lee, Lorenz Studer, Sang-Hun Lee

J Neurosci. 2004 Jan 28; 24(4): 843–852. doi: 10.1523/JNEUROSCI.3977-03.2004

PMCID:: PMC6729826

Article PDF–841K

Select item 45122587.

Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain

Julio D Perez, Nimrod D Rubinstein, Daniel E Fernandez, Stephen W Santoro, Leigh A Needleman, Olivia Ho-Shing, John J Choi, Mariela Zirlinger, Shau-Kwaun Chen, Jun S Liu, Catherine Dulac

eLife. 2015; 4: e07860. Published online 2015 Jul 3. doi: 10.7554/eLife.07860

PMCID:: PMC4512258

Article PDF–2.1M

Select item 41560598.

Bcl-x_L Protein Protects from C/EBP Homologous Protein (CHOP)-dependent Apoptosis during Plasma Cell Differentiation

Brian T. Gaudette, Neal N. Iwakoshi, Lawrence H. Boise

J Biol Chem. 2014 Aug 22; 289(34): 23629–23640. Published online 2014 Jul 14. doi: 10.1074/jbc.M114.569376

PMCID:: PMC4156059

Article PDF–1.1M

Select item 40661979.

Targeted disruption of Bcl-x_L in mouse keratinocytes inhibits both UVB- and chemically-induced skin carcinogenesis

Dae Joon Kim, Ken Kataoka, Shigetoshi Sano, Kevin Connolly, Kaoru Kiguchi, John DiGiovanni

Mol Carcinog. Author manuscript; available in PMC 2014 Jun 23.

Published in final edited form as: Mol Carcinog. 2009 Oct; 48(10): 873–885. doi: 10.1002/mc.20527

PMCID:: PMC4066197

Article PDF–2.9M

Select item 390854610.

A Novel Bcl-x Isoform Connected to the T Cell Receptor Regulates Apoptosis in T Cells

Xiao-Feng Yang, Georg F. Weber, Harvey Cantor

Immunity. Author manuscript; available in PMC 2014 Jan 31.

Published in final edited form as: Immunity. 1997 Nov; 7(5): 629–639. doi: 10.1016/s1074-7613(00)80384-2

PMCID:: PMC3908546

Article PDF–3.1M

Select item 383300211.

Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target

J.G. Harb, P. Neviani, B.J. Chyla, J.E. Ellis, G.J. Ferenchak, J.J. Oaks, C. J. Walker, P. Hokland, DC Roy, M.A. Caligiuri, G. Marcucci, C.S. Huettner, D. Perrotti

Leukemia. Author manuscript; available in PMC 2013 Nov 19.

Published in final edited form as: Leukemia. 2013 Oct; 27(10): 10.1038/leu.2013.151. Published online 2013 May 14. doi: 10.1038/leu.2013.151

PMCID:: PMC3833002

Article PDF–3.5M

Select item 338622312.

Distinct roles of mitochondria- and ER-localized Bcl-x_L in apoptosis resistance and Ca²⁺ homeostasis

Colins O. Eno, Emily F. Eckenrode, Kristen E. Olberding, Guoping Zhao, Carl White, Chi Li

Mol Biol Cell. 2012 Jul 1; 23(13): 2605–2618. doi: 10.1091/mbc.E12-02-0090

PMCID:: PMC3386223

Article PDF–2.5M

Select item 319816513.

Bcl-x_L regulates mitochondrial energetics by stabilizing the inner membrane potential

Ying-bei Chen, Miguel A. Aon, Yi-Te Hsu, Lucian Soane, Xinchen Teng, J. Michael McCaffery, Wen-Chih Cheng, Bing Qi, Hongmei Li, Kambiz N. Alavian, Margaret Dayhoff-Brannigan, Shifa Zou, Fernando J. Pineda, Brian O'Rourke, Young H. Ko, Peter L. Pedersen, Leonard K. Kaczmarek, Elizabeth A. Jonas, J. Marie Hardwick

J Cell Biol. 2011 Oct 17; 195(2): 263–276. doi: 10.1083/jcb.201108059

PMCID:: PMC3198165

Article PDF–2.7M

Select item 317600914.

The Role of Bcl-x_L in Mouse RPE Cell Survival

Sarah Medearis, Ian C. Han, Jessica K. Huang, Ping Yang, Glenn J. Jaffe

Invest Ophthalmol Vis Sci. 2011 Aug; 52(9): 6545–6551. Published online 2011 Aug 17. doi: 10.1167/iovs.10-6772

PMCID:: PMC3176009

Article PDF–1.8M

Select item 294502815.

Bcl-xL affects the development of functional CD4 Tregs

Amir Sharabi, Edna Mozes

Arthritis Res Ther. 2010; 12(4): 405. Published online 2010 Jul 23. doi: 10.1186/ar3076

PMCID:: PMC2945028

Article PDF–118K

Select item 293355316.

Epithelial Ablation of Bcl-X_L Increases Sensitivity to Oxygen without Disrupting Lung Development

Rhonda J. Staversky, Peter F. Vitiello, Min Yee, Linda M. Callahan, David A. Dean, Michael A. O'Reilly

Am J Respir Cell Mol Biol. 2010 Sep; 43(3): 376–385. Published online 2009 Oct 30. doi: 10.1165/rcmb.2009-0165OC

PMCID:: PMC2933553

Article PDF–2.3M

Select item 275023317.

Islet β-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli

Emma M. Carrington, Mark D. McKenzie, Elisa Jansen, Michelle Myers, Stacey Fynch, Cameron Kos, Andreas Strasser, Thomas W. Kay, Clare L. Scott, Janette Allison

Diabetes. 2009 Oct; 58(10): 2316–2323. Published online 2009 Jul 6. doi: 10.2337/db08-1602

PMCID:: PMC2750233

Article PDF–539K

Select item 267399218.

Biologically distinct conformations of Bcl-x can be resolved using 2D isoelectric focusing

Karen R. Rockwell, Brigitte T. Huber

Mol Immunol. Author manuscript; available in PMC 2010 May 1.

Published in final edited form as: Mol Immunol. 2009 May; 46(8-9): 1605–1612. Published online 2009 Mar 27. doi: 10.1016/j.molimm.2009.02.031

PMCID:: PMC2673992

Article PDF–1.0M

Select item 263596419.

Genetic Ablation of Bcl-x Attenuates Invasiveness without Affecting Apoptosis or Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Cancer

Jeffrey H. Hager, Danielle B. Ulanet, Lothar Hennighausen, Douglas Hanahan

PLoS One. 2009; 4(2): e4455. Published online 2009 Feb 11. doi: 10.1371/journal.pone.0004455

PMCID:: PMC2635964

Article PDF–876K

Select item 219401420.

T Cell Costimulation through CD28 Depends on Induction of the Bcl-xγ Isoform: Analysis of Bcl-xγ–deficient Mice

Qunrui Ye, Barry Press, Stephan Kissler, Xiao-Feng Yang, Linrong Lu, Craig H. Bassing, Barry P. Sleckman, Marianne Jansson, Vily Panoutsakopoulou, Linda A. Trimble, Frederick W. Alt, Harvey Cantor

J Exp Med. 2002 Jul 1; 196(1): 87–95. doi: 10.1084/jem.20012084