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Select item 102407011.

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

Hong Weng, Kang-Ping Xiong, Wang Wang, Kai-Yu Qian, Shuai Yuan, Gang Wang, Fang Yu, Jun Luo, Meng-Xin Lu, Zhong-Hua Yang, Tao Liu, Xing Huang, Hang Zheng, Xing-Huan Wang

Mil Med Res. 2023; 10: 25. Published online 2023 Jun 5. doi: 10.1186/s40779-023-00460-0

PMCID:: PMC10240701

Article PDF–18M

Select item 59106732.

Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model

Peter Bannerman, Fuzheng Guo, Olga Chechneva, Travis Burns, Xiaoqing Zhu, Yan Wang, Bokyung Kim, Naveen K. Singhal, Jennifer A. McDonough, David Pleasure

Mol Ther. 2018 Mar 7; 26(3): 793–800. Published online 2018 Jan 10. doi: 10.1016/j.ymthe.2018.01.002

PMCID:: PMC5910673

Article PDF–3.5M

Select item 52917253.

Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease

Dominic J. Gessler, Danning Li, Hongxia Xu, Qin Su, Julio Sanmiguel, Serafettin Tuncer, Constance Moore, Jean King, Reuben Matalon, Guangping Gao

JCI Insight. 2017 Feb 9; 2(3): e90807. Published online 2017 Feb 9. doi: 10.1172/jci.insight.90807

PMCID:: PMC5291725

Article PDF–1.2M

Select item 51027634.

N-acetylaspartate Supports the Energetic Demands of Developmental Myelination via Oligodendroglial Aspartoacylase

Jeremy S. Francis, Ireneusz Wojtas, Vladimir Markov, Steven J. Gray, Thomas J. McCown, R. Jude Samulski, Larissa T. Bilaniuk, Dah-Jyuu Wang, Darryl C. De Vivo, Christopher G. Janson, Paola Leone

Neurobiol Dis. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Neurobiol Dis. 2016 Dec; 96: 323–334. Published online 2016 Oct 4. doi: 10.1016/j.nbd.2016.10.001

PMCID:: PMC5102763

Article PDF–1.8M

Select item 40364725.

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

Marina R. Carpinelli, Anne K. Voss, Michael G. Manning, Ashwyn A. Perera, Anne A. Cooray, Benjamin T. Kile, Rachel A. Burt

Dis Model Mech. 2014 Jun; 7(6): 649–657. Published online 2014 Mar 28. doi: 10.1242/dmm.014605

PMCID:: PMC4036472

Article

Select item 40208306.

Loss of Central Auditory Processing in a Mouse Model of Canavan Disease

Georg von Jonquieres, Kristina E. Froud, Claudia B. Klugmann, Ann C. Y. Wong, Gary D. Housley, Matthias Klugmann

PLoS One. 2014; 9(5): e97374. Published online 2014 May 14. doi: 10.1371/journal.pone.0097374

PMCID:: PMC4020830

Article PDF–14M

Select item 34346297.

Aspartoacylase supports oxidative energy metabolism during myelination

Jeremy S Francis, Louise Strande, Vladamir Markov, Paola Leone

J Cereb Blood Flow Metab. 2012 Sep; 32(9): 1725–1736. Published online 2012 May 23. doi: 10.1038/jcbfm.2012.66

PMCID:: PMC3434629

Article PDF–838K

Select item 30988858.

Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease

Nadine Mersmann, Dmitri Tkachev, Ruth Jelinek, Philipp Thomas Röth, Wiebke Möbius, Torben Ruhwedel, Sabine Rühle, Wolfgang Weber-Fahr, Alexander Sartorius, Matthias Klugmann

PLoS One. 2011; 6(5): e20336. Published online 2011 May 20. doi: 10.1371/journal.pone.0020336

PMCID:: PMC3098885

Article PDF–4.4M

Select item 29648409.

Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination

Natalia S. Mattan, Cristina A. Ghiani, Marcia Lloyd, Reuben Matalon, Dean Bok, Patrizia Casaccia, Jean de Vellis

Neurobiol Dis. Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: Neurobiol Dis. 2010 Nov; 40(2): 432–443. Published online 2010 Jul 14. doi: 10.1016/j.nbd.2010.07.003

PMCID:: PMC2964840

Article PDF–2.9M

Select item 55503610.

Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease

Chikkathur N. Madhavarao, Peethambaran Arun, John R. Moffett, Sylvia Szucs, Sankar Surendran, Reuben Matalon, James Garbern, Diana Hristova, Anne Johnson, Wei Jiang, M. A. Aryan Namboodiri

Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14): 5221–5226. Published online 2005 Mar 22. doi: 10.1073/pnas.0409184102

PMCID:: PMC555036

Article PDF–418K

Select item 914266611.

Therapeutic development for Canavan disease using patient iPSCs introduced with the wild-type ASPA gene

Jianfei Chao, Lizhao Feng, Peng Ye, Xianwei Chen, Qi Cui, Guihua Sun, Tao Zhou, E Tian, Wendong Li, Weidong Hu, Arthur D. Riggs, Reuben Matalon, Yanhong Shi

iScience. 2022 Jun 17; 25(6): 104391. Published online 2022 May 11. doi: 10.1016/j.isci.2022.104391

PMCID:: PMC9142666

Article PDF–4.4M

Select item 660545812.

N-Acetylaspartate Synthase Deficiency Corrects the Myelin Phenotype in a Canavan Disease Mouse Model But Does Not Affect Survival Time

Helena Maier, Lihua Wang-Eckhardt, Dieter Hartmann, Volkmar Gieselmann, Matthias Eckhardt

J Neurosci. 2015 Oct 28; 35(43): 14501–14516. doi: 10.1523/JNEUROSCI.1056-15.2015

PMCID:: PMC6605458

Article PDF–9.1M

Select item 524239713.

Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy

Jiho Sohn, Peter Bannerman, Fuzheng Guo, Travis Burns, Laird Miers, Christopher Croteau, Naveen K. Singhal, Jennifer A. McDonough, David Pleasure

J Neurosci. 2017 Jan 11; 37(2): 413–421. doi: 10.1523/JNEUROSCI.2013-16.2016

PMCID:: PMC5242397

Article PDF–5.6M

Select item 575626114.

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy

Georg von Jonquieres, Ziggy H. T. Spencer, Benjamin D. Rowlands, Claudia B. Klugmann, Andre Bongers, Anne E. Harasta, Kristina E. Parley, Jennie Cederholm, Orla Teahan, Russell Pickford, Fabien Delerue, Lars M. Ittner, Dominik Fröhlich, Catriona A. McLean, Anthony S. Don, Miriam Schneider, Gary D. Housley, Caroline D. Rae, Matthias Klugmann

Acta Neuropathol. 2018; 135(1): 95–113. Published online 2017 Nov 7. doi: 10.1007/s00401-017-1784-9

PMCID:: PMC5756261

Article PDF–12M

Select item 411394215.

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

Emmanuel L. Gautier, Stoyan Ivanov, Jesse W. Williams, Stanley Ching-Cheng Huang, Genevieve Marcelin, Keke Fairfax, Peter L. Wang, Jeremy S. Francis, Paola Leone, David B. Wilson, Maxim N. Artyomov, Edward J. Pearce, Gwendalyn J. Randolph

J Exp Med. 2014 Jul 28; 211(8): 1525–1531. doi: 10.1084/jem.20140570

PMCID:: PMC4113942

Article PDF–2.0M

Select item 261329116.

Nur7 Is a Nonsense Mutation in the Mouse Aspartoacylase Gene That Causes Spongy Degeneration of the CNS

Maria Traka, Robert L. Wollmann, Sonia R. Cerda, Jason Dugas, Ben A. Barres, Brian Popko

J Neurosci. 2008 Nov 5; 28(45): 11537–11549. doi: 10.1523/JNEUROSCI.1490-08.2008

PMCID:: PMC2613291

Article PDF–1.1M

Select item 327853017.

Expression and localization of myosin-1d in the developing nervous system

Andrew E. Benesh, Jonathan T. Fleming, Chin Chiang, Bruce D. Carter, Matthew J. Tyska

Brain Res. Author manuscript; available in PMC 2013 Feb 27.

Published in final edited form as: Brain Res. 2012 Feb 27; 1440: 9–22. Published online 2012 Jan 8. doi: 10.1016/j.brainres.2011.12.054

PMCID:: PMC3278530

Article PDF–4.6M

Select item 371176418.

Adenomatous Polyposis Coli Regulates Oligodendroglial Development

Jordan Lang, Yoshiko Maeda, Peter Bannerman, Jie Xu, Makoto Horiuchi, David Pleasure, Fuzheng Guo

J Neurosci. 2013 Feb 13; 33(7): 3113–3130. doi: 10.1523/JNEUROSCI.3467-12.2013

PMCID:: PMC3711764

Article PDF–9.2M

Select item 571502019.

Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development

Kazuyuki Sumi, Kyosuke Uno, Hiroshi Noike, Takenori Tomohiro, Yasumaru Hatanaka, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta

Sci Rep. 2017; 7: 16872. Published online 2017 Dec 4. doi: 10.1038/s41598-017-17151-1

PMCID:: PMC5715020

Article PDF–3.1M

Select item 278213120.

Discovery of Candidate Disease Genes in ENU–Induced Mouse Mutants by Large-Scale Sequencing, Including a Splice-Site Mutation in Nucleoredoxin

Melissa K. Boles, Bonney M. Wilkinson, Laurens G. Wilming, Bin Liu, Frank J. Probst, Jennifer Harrow, Darren Grafham, Kathryn E. Hentges, Lanette P. Woodward, Andrea Maxwell, Karen Mitchell, Michael D. Risley, Randy Johnson, Karen Hirschi, James R. Lupski, Yosuke Funato, Hiroaki Miki, Pablo Marin-Garcia, Lucy Matthews, Alison J. Coffey, Anne Parker, Tim J. Hubbard, Jane Rogers, Allan Bradley, David J. Adams, Monica J. Justice

PLoS Genet. 2009 Dec; 5(12): e1000759. Published online 2009 Dec 11. doi: 10.1371/journal.pgen.1000759

PMCID:: PMC2782131

Article PDF–1.1M

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