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Select item 106230521.

Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis

DuoYao Cao, Suguru Saito, LiMin Xu, Wei Fan, Xiaomo Li, Faizan Ahmed, Predrag Jovanovic, Tomohiro Shibata, Mingtian Che, Ellen A. Bernstein, Jorge Gianni, Ajit S. Divakaruni, Derick Okwan-Duodu, Zakir Khan, Celine E. Riera, Fanfan Chen, Kenneth E. Bernstein

Front Immunol. 2023; 14: 1278383. Published online 2023 Oct 20. doi: 10.3389/fimmu.2023.1278383

PMCID:: PMC10623052

Article PDF–2.6M

Select item 99086622.

Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy

Annett Juretzko, Antje Steinbach, Jeannine Witte, Anke Hannemann, Bärbel Miehe, Florian Siegerist, Carmen Wolke, Sylvia Stracke, Rainer Rettig

Pflugers Arch. 2023; 475(3): 391–403. Published online 2022 Dec 15. doi: 10.1007/s00424-022-02779-4

PMCID:: PMC9908662

Article PDF–1.6M

Select item 81273983.

Novel roles of the renal angiotensin-converting enzyme

Jorge F. Giani, Luciana C. Veiras, Justin Z.Y. Shen, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein

Mol Cell Endocrinol. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Mol Cell Endocrinol. 2021 Jun 1; 529: 111257. Published online 2021 Mar 26. doi: 10.1016/j.mce.2021.111257

PMCID:: PMC8127398

Article PDF–328K

Select item 70959664.

Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization

Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi, Junji Takeda

Nat Med. 2005; 11(2): 160–166. Published online 2005 Jan 23. doi: 10.1038/nm1179

PMCID:: PMC7095966

Article PDF–1.2M

Select item 69968785.

ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP

Duo-Yao Cao, Weston R. Spivia, Luciana C. Veiras, Zakir Khan, Zhenzi Peng, Anthony E. Jones, Ellen A. Bernstein, Suguru Saito, Derick Okwan-Duodu, Sarah J. Parker, Jorge F. Giani, Ajit S. Divakaruni, Jennifer E. Van Eyk, Kenneth E. Bernstein

J Biol Chem. 2020 Jan 31; 295(5): 1369–1384. Published online 2019 Dec 23. doi: 10.1074/jbc.RA119.011244

PMCID:: PMC6996878

Article PDF–4.9M

Select item 69357526.

Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease

Maya Koronyo-Hamaoui, Julia Sheyn, Eric Y Hayden, Songlin Li, Dieu-Trang Fuchs, Giovanna C Regis, Dahabada H J Lopes, Keith L Black, Kenneth E Bernstein, David B Teplow, Sebastien Fuchs, Yosef Koronyo, Altan Rentsendorj

Brain. 2020 Jan; 143(1): 336–358. Published online 2019 Dec 3. doi: 10.1093/brain/awz364

Correction in:: Brain. 2020 Mar; 143(3): e24.

PMCID:: PMC6935752

Article PDF–2.4M

Select item 64330537.

Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization

Zakir Khan, Duo-Yao Cao, Jorge F. Giani, Ellen A. Bernstein, Luciana C. Veiras, Sebastien Fuchs, Yizhou Wang, Zhenzi Peng, Markus Kalkum, George Y. Liu, Kenneth E. Bernstein

J Biol Chem. 2019 Mar 22; 294(12): 4368–4380. Published online 2019 Jan 22. doi: 10.1074/jbc.RA118.006275

PMCID:: PMC6433053

Article PDF–3.6M

Select item 61712838.

The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease

Masahiro Eriguchi, Ellen A. Bernstein, Luciana C. Veiras, Zakir Khan, Duo Yao Cao, Sebastien Fuchs, Alicia A. McDonough, Jorge E. Toblli, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein, Jorge F. Giani

J Am Soc Nephrol. 2018 Oct; 29(10): 2546–2561. Published online 2018 Sep 5. doi: 10.1681/ASN.2018030323

PMCID:: PMC6171283

Article

Select item 60380589.

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

Oscar Albuquerque de Moraes, Karin Flues, Kátia Bilhar Scapini, Cristiano Mostarda, Fabiana de Sant’Anna Evangelista, Bruno Rodrigues, Daniela Ravizzoni Dartora, Patricia Fiorino, Kátia De Angelis, Maria Cláudia Irigoyen

Clinics (Sao Paulo) 2018; 73: e246. Published online 2018 Jul 10. doi: 10.6061/clinics/2018/e246

PMCID:: PMC6038058

Article PDF–540K

Select item 596676510.

Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy

Masahiro Eriguchi, Mercury Lin, Michifumi Yamashita, Tuantuan V. Zhao, Zakir Khan, Ellen A. Bernstein, Susan B. Gurley, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein, Jorge F. Giani

Am J Physiol Renal Physiol. 2018 Apr 1; 314(4): F531–F542. Published online 2017 Nov 29. doi: 10.1152/ajprenal.00523.2017

PMCID:: PMC5966765

Article

Select item 565738411.

Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity

Jorge F. Giani, Masahiro Eriguchi, Ellen A. Bernstein, Makoto Katsumata, Xiao Z. Shen, Liang Li, Alicia A. McDonough, Sebastien Fuchs, Kenneth E. Bernstein, Romer A. Gonzalez-Villalobos

Kidney Int. Author manuscript; available in PMC 2017 Oct 26.

Published in final edited form as: Kidney Int. 2017 Apr; 91(4): 856–867. Published online 2016 Dec 15. doi: 10.1016/j.kint.2016.10.007

PMCID:: PMC5657384

Article PDF–930K

Select item 552046812.

Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils

Zakir Khan, Xiao Z. Shen, Ellen A. Bernstein, Jorge F. Giani, Masahiro Eriguchi, Tuantuan V. Zhao, Romer A. Gonzalez-Villalobos, Sebastien Fuchs, George Y. Liu, Kenneth E. Bernstein

Blood. 2017 Jul 20; 130(3): 328–339. Prepublished online 2017 May 17. doi: 10.1182/blood-2016-11-752006

PMCID:: PMC5520468

Article

Select item 549349513.

Angiotensin converting enzyme affects the presentation of MHC class II antigens

Tuantuan Zhao, Kenneth E. Bernstein, Jianmin Fang, Xiao Z. Shen

Lab Invest. Author manuscript; available in PMC 2017 Oct 10.

Published in final edited form as: Lab Invest. 2017 Jul; 97(7): 764–771. Published online 2017 Apr 10. doi: 10.1038/labinvest.2017.32

PMCID:: PMC5493495

Article PDF–634K

Select item 449153714.

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension

Victor Garcia, Gregory Joseph, Brian Shkolnik, Yan Ding, Frank Fan Zhang, Katherine Gotlinger, John R. Falck, Rambabu Dakarapu, Jorge H. Capdevila, Kenneth E. Bernstein, Michal Laniado Schwartzman

Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1; 309(1): R71–R78. Published online 2015 Apr 29. doi: 10.1152/ajpregu.00039.2015

PMCID:: PMC4491537

Article

Select item 424334815.

Renal Angiotensin-Converting Enzyme Is Essential for the Hypertension Induced by Nitric Oxide Synthesis Inhibition

Jorge F. Giani, Tea Janjulia, Nikhil Kamat, Dale M. Seth, Wendell-Lamar B. Blackwell, Kandarp H. Shah, Xiao Z. Shen, Sebastien Fuchs, Eric Delpire, Jorge E. Toblli, Kenneth E. Bernstein, Alicia A. McDonough, Romer A. Gonzalez-Villalobos

J Am Soc Nephrol. 2014 Dec; 25(12): 2752–2763. Published online 2014 Jul 10. doi: 10.1681/ASN.2013091030

PMCID:: PMC4243348

Article

Select item 422124016.

Myeloid expression of angiotensin converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells

Xiao Z. Shen, Derick Okwan-Duodu, Wendell-Lamar Blackwell, Frank S. Ong, Tea Janjulia, Ellen A. Bernstein, Sebastien Fuchs, Serhan Alkan, Kenneth E. Bernstein

Lab Invest. Author manuscript; available in PMC 2014 Nov 6.

Published in final edited form as: Lab Invest. 2014 May; 94(5): 536–544. Published online 2014 Mar 10. doi: 10.1038/labinvest.2014.41

PMCID:: PMC4221240

Article PDF–4.5M

Select item 393416217.

Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer’s-like cognitive decline

Kenneth E. Bernstein, Yosef Koronyo, Brenda C. Salumbides, Julia Sheyn, Lindsey Pelissier, Dahabada H.J. Lopes, Kandarp H. Shah, Ellen A. Bernstein, Dieu-Trang Fuchs, Jeff J.-Y. Yu, Michael Pham, Keith L. Black, Xiao Z. Shen, Sebastien Fuchs, Maya Koronyo-Hamaoui

J Clin Invest. 2014 Mar 3; 124(3): 1000–1012. Published online 2014 Feb 3. doi: 10.1172/JCI66541

PMCID:: PMC3934162

Article PDF–4.6M

Select item 390367218.

Tissue-Specific Expression of Transgenic Secreted ACE in Vasculature Can Restore Normal Kidney Functions, but Not Blood Pressure, of Ace-/- Mice

Saurabh Chattopadhyay, Sean P. Kessler, Juliana Almada Colucci, Michifumi Yamashita, Preenie deS Senanayake, Ganes C. Sen

PLoS One. 2014; 9(1): e87484. Published online 2014 Jan 27. doi: 10.1371/journal.pone.0087484

PMCID:: PMC3903672

Article PDF–4.5M

Select item 386856219.

Contributions of Leukocytic Angiotensin-converting Enzyme to Development of Atherosclerosis

Xiaofeng Chen, Hong Lu, Mingming Zhao, Katsuya Tashiro, Lisa A. Cassis, Alan Daugherty

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9): 10.1161/ATVBAHA.113.301777. Published online 2013 Jul 11. doi: 10.1161/ATVBAHA.113.301777

PMCID:: PMC3868562

Article PDF–911K

Select item 363890720.

The absence of intrarenal ACE protects against hypertension

Romer A. Gonzalez-Villalobos, Tea Janjoulia, Nicholas K. Fletcher, Jorge F. Giani, Mien T.X. Nguyen, Anne D. Riquier-Brison, Dale M. Seth, Sebastien Fuchs, Dominique Eladari, Nicolas Picard, Sebastian Bachmann, Eric Delpire, Janos Peti-Peterdi, L. Gabriel Navar, Kenneth E. Bernstein, Alicia A. McDonough

J Clin Invest. 2013 May 1; 123(5): 2011–2023. Published online 2013 Apr 24. doi: 10.1172/JCI65460