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Select item 85588491.

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

Luise Eckardt, Maria Prange-Barczynska, Emma J Hodson, James W Fielding, Xiaotong Cheng, Joanna D C C Lima, Samvid Kurlekar, Gillian Douglas, Peter J Ratcliffe, Tammie Bishop

Endocr Relat Cancer. 2021 Dec 1; 28(12): 757–772. Published online 2021 Sep 20. doi: 10.1530/ERC-21-0211

PMCID:: PMC8558849

Article PDF–19M

Select item 83753872.

Hypoxia-Inducible Factor 2-Alpha Mediated Gene Sets Differentiate Pulmonary Arterial Hypertension

Jinsheng Zhu, Li Zhao, Yadan Hu, Guoqi Cui, Ang Luo, Changlei Bao, Ying Han, Tong Zhou, Wenju Lu, Jian Wang, Stephen M. Black, Haiyang Tang

Front Cell Dev Biol. 2021; 9: 701247. Published online 2021 Aug 5. doi: 10.3389/fcell.2021.701247

PMCID:: PMC8375387

Article PDF–6.8M

Select item 72280533.

Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice

Stephan Settelmeier, Timm Schreiber, Joni Mäki, Nadiya Byts, Peppi Koivunen, Johanna Myllyharju, Joachim Fandrey, Sandra Winning

PLoS One. 2020; 15(5): e0233261. Published online 2020 May 15. doi: 10.1371/journal.pone.0233261

PMCID:: PMC7228053

Article PDF–4.3M

Select item 72209834.

HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD

Anna Laitakari, Joona Tapio, Kari A. Mäkelä, Karl-Heinz Herzig, Franziska Dengler, Helena Gylling, Gail Walkinshaw, Johanna Myllyharju, Elitsa Y. Dimova, Raisa Serpi, Peppi Koivunen

J Mol Med (Berl) 2020; 98(5): 719–731. Published online 2020 Apr 15. doi: 10.1007/s00109-020-01903-0

PMCID:: PMC7220983

Article PDF–8.8M

Select item 67153805.

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

Atsushi Yamamoto, Joanna Hester, Philip S. Macklin, Kento Kawai, Masateru Uchiyama, Daniel Biggs, Tammie Bishop, Katherine Bull, Xiaotong Cheng, Eleanor Cawthorne, Mathew L. Coleman, Tanya L. Crockford, Ben Davies, Lukas E. Dow, Rob Goldin, Kamil Kranc, Hiromi Kudo, Hannah Lawson, James McAuliffe, Kate Milward, Cheryl L. Scudamore, Elizabeth Soilleux, Fadi Issa, Peter J. Ratcliffe, Chris W. Pugh

J Clin Invest. 2019 Sep 3; 129(9): 3640–3656. Published online 2019 Jul 29. doi: 10.1172/JCI124099

PMCID:: PMC6715380

Article PDF–16M

Select item 65039876.

Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism

Li-Juan Duan, Guo-Hua Fong

Development. 2019 Apr 15; 146(8): dev175117. Published online 2019 Apr 17. doi: 10.1242/dev.175117

PMCID:: PMC6503987

Article

Select item 63502537.

Regulatory Role of Endothelial PHD2 in the Hepatic Steatosis

Li-Ying Zhou, Heng Zeng, Shuo Wang, Jian-Xiong Chen

Cell Physiol Biochem. Author manuscript; available in PMC 2019 Jan 29.

Published in final edited form as: Cell Physiol Biochem. 2018; 48(3): 1003–1011. Published online 2018 Jul 23. doi: 10.1159/000491968

PMCID:: PMC6350253

Article PDF–1.2M

Select item 63153278.

Prolyl Hydroxylase Domain-2 Protein Regulates Lipopolysaccharide-Induced Vascular Inflammation

Qiying Fan, Hua Mao, Liang Xie, Xinchun Pi

Am J Pathol. 2019 Jan; 189(1): 200–213. doi: 10.1016/j.ajpath.2018.09.012

PMCID:: PMC6315327

Article

Select item 57473149.

PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing

Sae Hee Ko, Allison C. Nauta, Shane D. Morrison, Michael S. Hu, Andrew S. Zimmermann, Michael T. Chung, Jason P. Glotzbach, Victor W. Wong, Graham G. Walmsley, H. Peter Lorenz, Denise A. Chan, Geoffrey C. Gurtner, Amato J. Giaccia, Michael T. Longaker

Plast Reconstr Surg. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Plast Reconstr Surg. 2018 Jan; 141(1): 55e–67e. doi: 10.1097/PRS.0000000000003959

PMCID:: PMC5747314

Article PDF–1.1M

Select item 557155210.

Ablation of endothelial prolyl hydroxylase domain protein‐2 promotes renal vascular remodelling and fibrosis in mice

Shuo Wang, Heng Zeng, Sean T. Chen, Liying Zhou, Xue‐Jiao Xie, Xiaochen He, Yong‐Kang Tao, Qin‐hui Tuo, Changqin Deng, Duan‐fang Liao, Jian‐Xiong Chen

J Cell Mol Med. 2017 Sep; 21(9): 1967–1978. Published online 2017 Mar 7. doi: 10.1111/jcmm.13117

PMCID:: PMC5571552

Article PDF–3.6M

Select item 531228011.

Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling

Shuo Wang, Heng Zeng, Xue-Jiao Xie, Yong-Kang Tao, Xiaochen He, Richard J. Roman, Judy L. Aschner, Jian-Xiong Chen

Oncotarget. 2016 Sep 13; 7(37): 58848–58861. Published online 2016 Aug 24. doi: 10.18632/oncotarget.11585

PMCID:: PMC5312280

Article PDF–4.8M

Select item 513338812.

Tumor hypoxia causes DNA hypermethylation by reducing TET activity

Bernard Thienpont, Jessica Steinbacher, Hui Zhao, Flora D’Anna, Anna Kuchnio, Athanasios Ploumakis, Bart Ghesquière, Laurien Van Dyck, Bram Boeckx, Luc Schoonjans, Els Hermans, Frederic Amant, Vessela N. Kristensen, Kian Peng Koh, Massimiliano Mazzone, Mathew Coleman, Thomas Carell, Peter Carmeliet, Diether Lambrechts

Nature. Author manuscript; available in PMC 2017 Feb 17.

Published in final edited form as: Nature. 2016 Sep 1; 537(7618): 63–68. Published online 2016 Aug 17. doi: 10.1038/nature19081

PMCID:: PMC5133388

Article PDF–5.7M

Select item 507577913.

Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Regulates Chondrocyte Differentiation and Secondary Ossification in Mice

Shaohong Cheng, Patrick Aghajanian, Sheila Pourteymoor, Catrina Alarcon, Subburaman Mohan

Sci Rep. 2016; 6: 35748. Published online 2016 Oct 24. doi: 10.1038/srep35748

PMCID:: PMC5075779

Article PDF–1.5M

Select item 470188614.

Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation

Shaohong Cheng, Weirong Xing, Sheila Pourteymoor, Jan Schulte, Subburaman Mohan

Endocrinology. 2016 Jan; 157(1): 127–140. Published online 2015 Nov 12. doi: 10.1210/en.2015-1473

PMCID:: PMC4701886

Article

Select item 403786815.

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Massimiliano Mazzone, Daniela Dettori, Rodrigo Leite de Oliveira, Sonja Loges, Thomas Schmidt, Bart Jonckx, Ya-Min Tian, Anthony A. Lanahan, Patrick Pollard, Carmen Ruiz de Almodovar, Frederik De Smet, Stefan Vinckier, Julián Aragonés, Koen Debackere, Aernout Luttun, Sabine Wyns, Benedicte Jordan, Alberto Pisacane, Bernard Gallez, Maria Grazia Lampugnani, Elisabetta Dejana, Michael Simons, Peter Ratcliffe, Patrick Maxwell, Peter Carmeliet

Cell. Author manuscript; available in PMC 2014 May 29.

Published in final edited form as: Cell. 2009 Mar 6; 136(5): 839–851. Published online 2009 Feb 12. doi: 10.1016/j.cell.2009.01.020

PMCID:: PMC4037868

Article PDF–3.1M

Select item 386984716.

Wound Healing Improvement with PHD-2 Silenced Fibroblasts in Diabetic Mice

Xiongliang Zhang, Xiaoyu Yan, Liang Cheng, Jiezhi Dai, Chunyang Wang, Pei Han, Yimin Chai

PLoS One. 2013; 8(12): e84548. Published online 2013 Dec 20. doi: 10.1371/journal.pone.0084548

PMCID:: PMC3869847

Article PDF–1.7M

Select item 375390017.

Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection

Risto Kerkelä, Sara Karsikas, Zoltan Szabo, Raisa Serpi, Johanna Magga, Erhe Gao, Kari Alitalo, Andrey Anisimov, Raija Sormunen, Ilkka Pietilä, Laura Vainio, Walter J. Koch, Kari I. Kivirikko, Johanna Myllyharju, Peppi Koivunen

Mol Cell Biol. 2013 Aug; 33(16): 3321–3329. doi: 10.1128/MCB.00432-13

PMCID:: PMC3753900

Article PDF–2.3M

Select item 365750718.

Short hairpin RNA interference therapy for ischemic heart disease

Mei Huang, Denise Chan, Fangjun Jia, Xiaoyan Xie, Zongjin Li, Grant Hoyt, Robert C. Robbins, Xiaoyuan Chen, Amato Giaccia, Joseph C. Wu

Circulation. Author manuscript; available in PMC 2013 May 19.

Published in final edited form as: Circulation. 2008 Sep 30; 118(14 0): S226–S233. doi: 10.1161/CIRCULATIONAHA.107.760785

PMCID:: PMC3657507

Article PDF–2.5M

Select item 1029377319.

Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1

Fan Li, Fenglin Zhang, Xin Yi, Lu Lu Quan, Xiaohua Yang, Cong Yin, Zewei Ma, Ruifan Wu, Weijie Zhao, Mingfa Ling, Limin Lang, Abdelaziz Hussein, Shengchun Feng, Yiming Fu, Junfeng Wang, Shuyi Liang, Canjun Zhu, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Yongliang Zhang, Lin Zhang, Gang Shu, Qingyan Jiang, Songbo Wang

Mol Metab. 2023 Jul; 73: 101747. Published online 2023 Jun 4. doi: 10.1016/j.molmet.2023.101747

PMCID:: PMC10293773

Article PDF–4.0M

Select item 761106920.

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Post-Implantation Cell Survival

Steve Stegen, Nick van Gastel, Guy Eelen, Bart Ghesquière, Flora D’Anna, Bernard Thienpont, Jermaine Goveia, Sophie Torrekens, Riet Van Looveren, Frank P. Luyten, Patrick H. Maxwell, Ben Wielockx, Diether Lambrechts, Sarah-Maria Fendt, Peter Carmeliet, Geert Carmeliet

Cell Metab. Author manuscript; available in PMC 2021 Jun 24.

Published in final edited form as: Cell Metab. 2016 Feb 9; 23(2): 265–79. doi: 10.1016/j.cmet.2016.01.002

PMCID:: PMC7611069

Article PDF–3.0M

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