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Select item 96366841.

Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment

Annika Stutz, Gopala Nishanth, Ana C. Zenclussen, Anne Schumacher

BMC Res Notes. 2022; 15: 341. Published online 2022 Nov 5. doi: 10.1186/s13104-022-06230-w

PMCID:: PMC9636684

Article PDF–1.0M

Select item 65178252.

OTUB1 inhibits CNS autoimmunity by preventing IFN‐γ‐induced hyperactivation of astrocytes

Xu Wang, Floriana Mulas, Wenjing Yi, Anna Brunn, Gopala Nishanth, Sissy Just, Ari Waisman, Wolfgang Brück, Martina Deckert, Dirk Schlüter

EMBO J. 2019 May 15; 38(10): e100947. Published online 2019 Apr 3. doi: 10.15252/embj.2018100947

PMCID:: PMC6517825

Article PDF–3.4M

Select item 100798383.

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2

Qiong Zhu, Yesheng Fu, Chun-Ping Cui, Yi Ding, Zhikang Deng, Chao Ning, Fan Hu, Chen Qiu, Biyue Yu, Xuemei Zhou, Guan Yang, Jiang Peng, Weiguo Zou, Cui Hua Liu, Lingqiang Zhang

Signal Transduct Target Ther. 2023; 8: 142. Published online 2023 Apr 7. doi: 10.1038/s41392-023-01354-2

PMCID:: PMC10079838

Article PDF–5.3M

Select item 91635154.

ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1

Xiaodan Zhong, Tao Wang, Wenjun Zhang, Mengwen Wang, Yang Xie, Lei Dai, Xingwei He, Thati Madhusudhan, Hesong Zeng, Hongjie Wang

J Biol Chem. 2022 Jun; 298(6): 101989. Published online 2022 Apr 28. doi: 10.1016/j.jbc.2022.101989

PMCID:: PMC9163515

Article PDF–3.2M

Select item 65884075.

The deubiquitinase Otub1 controls the activation of CD8 T cells and NK cells by regulating IL-15-mediated priming

Xiaofei Zhou, Jiayi Yu, Xuhong Cheng, Baoyu Zhao, Ganiraju C Manyam, Li Zhang, Kimberly Schluns, Pingwei Li, Jing Wang, Shao-Cong Sun

Nat Immunol. Author manuscript; available in PMC 2019 Dec 10.

Published in final edited form as: Nat Immunol. 2019 Jul; 20(7): 879–889. Published online 2019 Jun 10. doi: 10.1038/s41590-019-0405-2

PMCID:: PMC6588407

Article PDF–3.3M

Select item 52896116.

GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection

Cinthia C. Stempin, Jorge D. Rojas Marquez, Yamile Ana, Fabio M. Cerban

PLoS Negl Trop Dis. 2017 Jan; 11(1): e0005307. Published online 2017 Jan 23. doi: 10.1371/journal.pntd.0005307

PMCID:: PMC5289611

Article PDF–1.3M

Select item 88360187.

The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism

Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monné Rodríguez, Julia Günter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz

Int J Mol Sci. 2022 Feb; 23(3): 1536. Published online 2022 Jan 28. doi: 10.3390/ijms23031536

PMCID:: PMC8836018

Article PDF–3.1M

Select item 82576888.

OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation

Josephin Koschel, Gopala Nishanth, Sissy Just, Kunjan Harit, Andrea Kröger, Martina Deckert, Michael Naumann, Dirk Schlüter

Cell Death Differ. 2021 Jul; 28(7): 2257–2275. Published online 2021 Mar 12. doi: 10.1038/s41418-021-00752-9

Correction in:: Cell Death Differ. 2022 Apr; 29(4): 891.

PMCID:: PMC8257688

Article PDF–6.7M

Select item 81671189.

The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13

Floriana Mulas, Xu Wang, Shanshan Song, Gopala Nishanth, Wenjing Yi, Anna Brunn, Pia-Katharina Larsen, Berend Isermann, Ulrich Kalinke, Antonio Barragan, Michael Naumann, Martina Deckert, Dirk Schlüter

Cell Mol Immunol. 2021 Jun; 18(6): 1512–1527. Published online 2020 Feb 5. doi: 10.1038/s41423-020-0362-6

PMCID:: PMC8167118

Article PDF–4.4M

Select item 539000710.

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Peng Wang, Gerard Joberty, Arjan Buist, Alexandre Vanoosthuyse, Ilie-Cosmin Stancu, Bruno Vasconcelos, Nathalie Pierrot, Maria Faelth-Savitski, Pascal Kienlen-Campard, Jean-Noël Octave, Marcus Bantscheff, Gerard Drewes, Diederik Moechars, Ilse Dewachter

Acta Neuropathol. 2017; 133(5): 731–749. Published online 2017 Jan 12. doi: 10.1007/s00401-016-1663-9

PMCID:: PMC5390007

Article PDF–3.0M

Select item 625434111.

OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination

Nagesh Pasupala, Marie E. Morrow, Lauren T. Que, Barbara A. Malynn, Averil Ma, Cynthia Wolberger

J Biol Chem. 2018 Nov 23; 293(47): 18285–18295. Published online 2018 Oct 2. doi: 10.1074/jbc.RA118.004677

PMCID:: PMC6254341

Article PDF–1.0M

Select item 1004087612.

SET7 methylates the deubiquitinase OTUB1 at Lys ¹²² to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis

Hongyan Deng, Shuke Jia, Jinhua Tang, Fangjing Rong, Chenxi Xu, Xiaoyun Chen, Zixuan Wang, Chunchun Zhu, Xueyi Sun, Qian Liao, Wen Liu, Wenhua Li, Wuhan Xiao, Xing Liu

J Biol Chem. 2023 Apr; 299(4): 103054. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103054

PMCID:: PMC10040876

Article PDF–3.0M

Select item 679686413.

Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization

Yanchuan Li, Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi, Daniel Lin, Meidi Gu, Xiaofei Zhou, Haiyan S. Li, Stephanie S. Watowich, Antrix Jain, Sung Yun Jung, Jun Qin, Xuhong Cheng, Shao-Cong Sun

Cell Res. 2019 Jun; 29(6): 474–485. Published online 2019 May 13. doi: 10.1038/s41422-019-0174-3

PMCID:: PMC6796864

Article PDF–4.8M

Select item 379148114.

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

Lina Herhaus, Mazin Al-Salihi, Thomas Macartney, Simone Weidlich, Gopal P. Sapkota

Nat Commun. 2013 Sep 27; 4: 2519. Published online 2013 Sep 27. doi: 10.1038/ncomms3519

PMCID:: PMC3791481

Article PDF–2.3M

Select item 476078015.

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling

Akhee S. Jahan, Maxime Lestra, Lee Kim Swee, Ying Fan, Mart M. Lamers, Fikadu G. Tafesse, Christopher S. Theile, Eric Spooner, Roberto Bruzzone, Hidde L. Ploegh, Sumana Sanyal

Proc Natl Acad Sci U S A. 2016 Feb 9; 113(6): E705–E714. Published online 2016 Jan 25. doi: 10.1073/pnas.1521763113

PMCID:: PMC4760780

Article PDF–1.4M

Select item 972465716.

The AAA‐ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle

Dina Aweida, Shenhav Cohen

EMBO Rep. 2022 Dec; 23(12): e55175. Published online 2022 Oct 24. doi: 10.15252/embr.202255175

PMCID:: PMC9724657

Article PDF–3.0M

Select item 250023417.

A Generic Approach for the Purification of Signaling Complexes That Specifically Interact with the Carboxyl-terminal Domain of G Protein-coupled Receptors

Pascal Maurice, Avais M. Daulat, Cédric Broussard, Julien Mozo, Guilhem Clary, Françoise Hotellier, Philippe Chafey, Jean-Luc Guillaume, Gilles Ferry, Jean A. Boutin, Philippe Delagrange, Luc Camoin, Ralf Jockers

Mol Cell Proteomics. 2008 Aug; 7(8): 1556–1569. doi: 10.1074/mcp.M700435-MCP200