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Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated with compound for 5 mins followed by substrate addition and measured after 2 mins by fluorescence spectrum analysis
Assay data:2 Active, 3 Tested
SummaryRelated BioAssays by Target
Inhibition of ovine COX-2 assessed as reduction in PGF2alpha production by enzyme immunoassay
Assay data:1 Active, 1 Tested
Inhibition of ovine COX-2
Assay data:8 Active, 8 Tested
Inhibition of ovine COX-1
Assay data:6 Active, 1 Activity ≤ 1 µM, 8 Tested
Inhibition of sheep COX-2 by Cayman colorimetric analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of ovine COX-2 colorimetric enzyme immunoassay
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Inhibition of ovine COX-1 at 1 uM
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of ovine COX-1 by EIA method
Assay data:8 Active, 4 Activity ≤ 1 µM, 11 Tested
Assay data:5 Active, 5 Activity ≤ 1 µM, 7 Tested
Assay data:3 Active, 7 Tested
Inhibition of sheep brain tubulin polymerization by DAPI staining based fluorescence analysis
Summary
Inhibition of ovine COX-1 using arachidonic acid as substrate at 10 uM preincubated with compound for 5 mins followed by substrate addition and measured after 2 mins by fluorescence spectrum analysis
Assay data:4 Active, 4 Tested
Inhibition of COX1 in ovine thrombocyte at 10 uM relative to control
Assay data:13 Tested
Hemolytic activity in sheep RBC assessed as hemolysis at 128 uM
Assay data:1 Tested
Hemolytic activity in sheep RBC assessed as hemolysis
Inhibition of full-length ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry
Assay data:2 Active, 1 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity index, ratio of IC50 for ovine COX-2 to IC50 for ovine COX-1
Assay data:8 Tested
Selectivity index, ratio of IC50 for inhibition of ovine COX-1 to IC50 for inhibition of ovine COX-2
Assay data:12 Tested
Hemolytic activity in 2% sheep RBC assessed as hemolysis at 16 to 256 ug/ml incubated for 3 hrs
Hemolytic activity in sheep RBC incubated for 1 hr by absorbance based analysis
Assay data:39 Tested
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