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Cmax in dog at 75 mg/kg/day, po QD for 4 days
Assay data:1 Tested
Summary
Cmax in dog at 30 mg/kg/day, po QD for 4 days
Cmax in dog at 10 mg/kg/day, po QD for 4 days
Cmax in Beagle dog at 1 mg/kg, po
Assay data:1 Active, 1 Tested
Antiplatelet activity activity in iv dosed dog assessed as platelet aggregation
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of SN-38 sensitive dog MDCK-II-BCRP cells expressing BCRP measured for 72 hrs by MTT assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiproliferative activity against dog MDCK-II cells assessed as reduction in cell viability measured for 72 hrs bt MTT assay
Antiproliferative activity against dog MDCK-II-BCRP cells assessed as reduction in cell viability measured for 72 hrs bt MTT assay
Inhibition of cell growth in SN-38 resistant dog MDCK-II-BCRP cells expressing BCRP measured for 72 hrs by MTT assay
Reversal of SN-38 resistance in dog MDCK-II-BCRP cells assessed as SN-38 GI50 at 10 uM measured for 72 hrs by MTT assay
Reversal of SN-38 resistance in dog MDCK-II-BCRP cells assessed as SN-38 GI50 at 1 uM measured for 72 hrs by MTT assay
Reversal of SN-38 resistance in dog MDCK-II-BCRP cells assessed as SN-38 GI50 at 0.1 uM measured for 72 hrs by MTT assay
Reversal of drug resistance in dog MDCK-II-BCRP cells expressing BCRP
Cytotoxicity against MDCK cells incubated for 48 hrs by MTT assay
Assay data:13 Tested
Cytotoxicity against dog MDCK cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 13 Tested
Cytotoxicity against dog MDCK cells infected with Influenza B virus
Cytotoxicity against dog MDCK cells infected with Influenza A virus H3N2
Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1
Cytotoxicity against dog MDCK cells infected with Influenza B virus assessed as reduction in cell viability by neutral red dye based analysis
Cytotoxicity against dog MDCK cells infected with Influenza B virus assessed as reduction in cell viability by visual analysis
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