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Binding affinity to chimpanzee P2Y14 assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Summary
Half life in Chimpanzee at 0.5 mg/kg administered as iv infusion
Assay data:2 Tested
Clearance in Chimpanzee at 0.5 mg/kg administered as iv infusion
Half-life in Chimpanzee at 0.5 mg/kg, iv bolus injection
Clearance in Chimpanzee at 0.5 mg/kg, iv bolus injection
FLIPR Ca2+ assay (monkey TRPA1)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Binding assay with 2% HSA
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding assay (no HSA)
FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of chimpanzee P2Y14 receptor
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of chimpanzee serum C1q-mediated rabbit RBC lysis after 60 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antagonist activity against chimpanzee GPR105 expressed in stable HEK cells co-expressing chimeric G-protein Gqi5 assessed as inhibition of UDP-glucose-induced Ca2+ signaling response incubated for 20 mins by FLIPR assay
Assay data:40 Active, 40 Activity ≤ 1 µM, 40 Tested
Cmax in chimpanzee at 1 mg/kg, po
Oral bioavailability in chimpanzee at 5 mg/kg
Assay data:1 Tested
SummaryPubMed Citation
Terminal half life in chimpanzee at 1 mg/kg, po
AUC (infinity) in chimpanzee at 1 mg/kg, po
Tmax in chimpanzee at 1 mg/kg, po
Terminal volume of distribution in chimpanzee at 0.5 mg/kg, iv
Plasma clearance in chimpanzee at 0.5 mg/kg, iv
Terminal half life in chimpanzee at 0.5 mg/kg, iv
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