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Antiarrhythmic activity in haploinsufficient FKBP12.6 expressing mouse assessed as plasma concentration showing prevention of cardiac arrhythmias dosed via osmotic mini-pump under testing exercise followed by epinephrine injection relative to control
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Antiarrhythmic activity in haploinsufficient FKBP12.6 expressing mouse assessed as plasma concentration showing prevention of sudden cardiac death dosed via osmotic mini-pump under testing exercise followed by epinephrine injection relative to control
Inhibition of human ERG expressed in HEK293 cells assessed as reduction in outward tail current after 5 mins at -80 mV holding potential by patch clamp assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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