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Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human recombinant CYP1A2 expressed in HEK293 cells using 3-cyano-7-ethoxycoumarin substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay relative to control
Assay data:11 Active, 6 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by fluorescence assay relative to control
Assay data:11 Active, 4 Activity ≤ 1 µM, 11 Tested
qHTS assay to identify small molecule antagonists of the constitutive androstane receptor (CAR) signaling pathway: Summary
Assay data:196 Active, 134 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the constitutive androstane receptor (CAR) signaling pathway
Assay data:575 Active, 6 Activity ≤ 1 nM, 184 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary
Assay data:1063 Active, 1 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary
Assay data:670 Active, 220 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway
Assay data:788 Active, 71 Activity ≤ 1 µM, 10486 Tested
TP_TRANSPORTER: increase uptake (Vinblastine: 0.01 uM) in Caco-2 cells
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
Assay data:7 Active, 2 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
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