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Inhibition of human sEH using cyano(6-methoxynaphthalen-2-yl)methyl((3-phenyloxiran-2-yl)methyl)carbonate as a substrate assessed as reduction in 6-methoxynaphthaldehyde formation by fluorescence microplate reader assay
Assay data:14 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US10383835: "Treatment of inflammatory disorders in non-human mammals"
Assay data:25 Active, 6 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of sEH (unknown origin) expressed in baculovirus expression system incubated for 1 hr
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for 30 mins by fluorescence based assay
Assay data:24 Active, 2 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 26 Tested
Inhibition of human sEH using epoxy flour 7 as substrate measured after 30 mins by cell-based fluorescence assay
Assay data:13 Active, 4 Activity ≤ 1 µM, 14 Tested
Inhibition of soluble epoxide hydrolase (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of soluble epoxide hydrolase (unknown origin) using NEPC as substrate after 1 hr by fluorescence assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of soluble epoxide hydrolase (unknown origin) using PHOME as substrate measured for 1 hr by fluorescence assay
Assay data:6 Active, 3 Activity ≤ 1 µM, 11 Tested
Inhibition of recombinant human soluble epoxide hydrolase using PHOME as substrate incubated for 5 mins followed by substrate addition by fluorescence assay
Assay data:9 Active, 4 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured after 10 mins by liquid scintillation counter method
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of soluble epoxide hydrolase (unknown origin) using 14,15-EET as substrate incubated for 20 mins by LC-MS/MS analysis
Assay data:21 Active, 15 Activity ≤ 1 µM, 23 Tested
Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl)-methyl ester as substrate
Assay data:2 Active, 1 Activity ≤ 1 µM, 11 Tested
Inhibition of sEH (unknown origin) using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde measured during 1 hr by fluorescence photometric analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 9 Tested
Inhibition of recombinant human sEH using CMNPC substrate by fluoresecent-based assay
Assay data:21 Active, 33 Activity ≤ 1 µM, 33 Tested
Inhibition of recombinant purified chicken soluble epoxide hydrolase using fluorescent PHOME as substrate
Assay data:39 Active, 39 Activity ≤ 1 µM, 39 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence method
Assay data:1 Active, 1 Activity ≤ 1 µM, 16 Tested
Inhibition of human recombinant soluble epoxide hydrolase using (3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxy-naphtalen-2-yl)-methyl ester as substrate incubated for 15 mins prior to substrate addition by fluorescence assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 10 Tested
Inhibition of recombinant human sEH expressed in Escherichia coli assessed as inhibition of substrate PHOME hydrolysis to 6-methoxy-2-naphthaldehyde after 5 mins by fluorescence assay
Assay data:6 Active, 1 Activity ≤ 1 µM, 30 Tested
Inhibition of human recombinant 5-LO expressed in Escherichia coli after 15 mins by HPLC analysis
Assay data:24 Active, 19 Activity ≤ 1 µM, 25 Tested
Inhibition of recombinant soluble epoxide hydrolase using PHOME as substrate after 10 mins by fluorescence assay
Assay data:17 Active, 15 Activity ≤ 1 µM, 22 Tested
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