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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
Summary
Inhibition of N-terminal GST-tagged full length human BTK (2 to 659 residues) expressed in Sf21 insect cells using 5-FAM-EAIYAAPFAKKK as substrate incubated for 60 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins in presence of ATP
Inhibition of GST-tagged human CDK2/Cyclin A2 expressed in baculovirus infected Sf9 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins in presence of ATP
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant full length human C-terminal His6-tagged CDK7/untagged recombinant full length human Cyclin H/N-terminal GST-tagged recombinant full length human MAT1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate incubated for 60 mins in presence of ATP
Inhibition of C-terminal His6 tagged full length recombinant human CDK9/full length human Cyclin T1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate incubated for 60 mins in presence of ATP
Inhibition of full length human CDK6/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate incubated for 60 mins in presence of ATP
Inhibition of full length human CDK4/N-terminal GST fused human cyclinD3 expressed in baculovirus expression system using 5-FAMIPTSPITTTYFFFKKK-COOH as substrate incubated for 60 mins in presence of ATP
Inhibition of ALK (unknown origin) pre-incubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by mobility shifting assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of CDK6/Cyclin D3 (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of CDK4/Cyclin D1 (unknown origin)
Inhibition of GSK-3beta (unknown origin)
Assay data:11 Active, 11 Activity ≤ 1 µM, 12 Tested
Inhibition of telomerase activity in human SGC-7901 cells incubated for 24 hrs by TRAP-PCR-ELISA assay
Assay data:3 Active, 4 Tested
Inhibition of DYRK1A (unknown origin)
Assay data:21 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 25 Tested
Binding affinity to recombinant MERTK (unknown origin) assessed as dissociation constant by DSF assay
Binding affinity to recombinant MST3 (unknown origin) assessed as dissociation constant by DSF assay
Binding affinity to recombinant STK4 (unknown origin) assessed as dissociation constant by DSF assay
Binding affinity to recombinant CDK2 (unknown origin) assessed as dissociation constant by DSF assay
Binding affinity to recombinant MAPK15 (unknown origin) assessed as dissociation constant by DSF assay
Binding affinity to recombinant MARK4 (unknown origin) assessed as dissociation constant by DSF assay
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