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Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
Assay data:39 Active, 2 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 39 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
Assay data:10 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 10 Tested
Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
Assay data:20 Active, 2 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 20 Tested
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 24 hrs by beta-galactosidase reporter gene assay
Assay data:24 Active, 2 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 29 Tested
Agonist activity at mouse MC5R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 34 Tested
Agonist activity at mouse MC3R expressed in HEK293 cells assessed as induction of cAMP level incubated for 2 hr by alphaScreen assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 31 Tested
Agonist activity at mouse MC1R expressed in HEK293 cells assessed as induction of cAMP level at 100 uM incubated for 2 hr by alphaScreen assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 14 Tested
Agonist activity at mouse MC5R by alphascreen cAMP assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 7 Tested
Agonist activity at mouse MC4R by alphascreen cAMP assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 14 Tested
Agonist activity at mouse MC3R by alphascreen cAMP assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 12 Tested
Agonist activity at mouse MC1R by alphascreen cAMP assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 10 Tested
Agonist activity at mouse melanocortin receptor 4 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay
Assay data:4 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
Agonist activity at mouse melanocortin receptor 3 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay
Assay data:13 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
Agonist activity at mouse melanocortin receptor 5 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay
Agonist activity at mouse melanocortin receptor 1 expressed in HEK293 cells assessed as stimulation of cAMP accumulation incubated for 2 hrs by cAMP Alpha-screen assay
Assay data:13 Active, 5 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
Full agonist activity at mouse MC5R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay
Assay data:43 Active, 33 Activity ≤ 1 µM, 45 Tested
Full agonist activity at mouse MC1R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay
Assay data:43 Active, 11 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 45 Tested
Agonist activity at mouse MC4R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay
Assay data:27 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 34 Tested
Agonist activity at mouse MC3R expressed in HEK293 cells co-expressing CRE/beta-galactosidase reporter gene after 6 hrs by beta-galactosidase cAMP assay
Assay data:36 Active, 1 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 45 Tested
Displacement of [125I]-NDP-MSH from human melanocortin receptor 4 expressed in HEK293 cell mebranes incubated for 1 hr by automatic gamma counting method
Assay data:7 Active, 5 Activity ≤ 1 µM, 11 Tested
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