BioAssays, Active for PubChem Compound (Select 159516) - PubChem BioAssay - NCBI

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Select item 19311321.

Inhibition of ABHD6 (unknown origin)

Source:: ChEMBL

Protein Target:: Monoacylglycerol lipase ABHD6

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1931132

Summary Related BioAssays by Target

Select item 19291242.

Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay

Source:: ChEMBL

Assay data:16 Active, 12 Activity ≤ 1 µM, 16 Tested

AID:: 1929124

Select item 19291233.

Antiproliferative activity against human KB cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay

Source:: ChEMBL

Assay data:16 Active, 13 Activity ≤ 1 µM, 16 Tested

AID:: 1929123

Select item 19291224.

Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay

Source:: ChEMBL

Assay data:47 Active, 46 Activity ≤ 1 µM, 47 Tested

AID:: 1929122

Select item 19291215.

Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay

Source:: ChEMBL

Assay data:16 Active, 5 Activity ≤ 1 µM, 16 Tested

AID:: 1929121

Select item 19194626.

Metabolic Measurements from US Patent US11660306: "Treatment of Rett syndrome"

Source:: BindingDB

Protein Targets:: Tyrosine-protein phosphatase non-receptor type 1; ...
Total:: 1

Assay data:21 Active, 3 Activity ≤ 1 µM, 28 Tested

AID:: 1919462

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18058017.

Various Assay from Article 10.1021/acs.jmedchem.1c00409: "Perspectives on SARS-CoV-2 Main Protease Inhibitors."

Source:: BindingDB

Protein Targets:: Replicase polyprotein 1ab; ...
Total:: 2

Assay data:473 Active, 1 Activity ≤ 1 nM, 248 Activity ≤ 1 µM, 795 Tested

AID:: 1805801

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 17590788.

Inhibition of recombinant rat MAGL by LC-MS analysis

Source:: ChEMBL

Protein Target:: Monoglyceride lipase

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1759078

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 17458559.

NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:48 Active, 86 Activity ≤ 1 µM, 637 Tested

AID:: 1745855

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 174585410.

NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:25 Active, 678 Tested

AID:: 1745854

Summary Compounds, Active PubMed Citation Related BioAssays by Depositor

Select item 167557111.

Antiproliferative activity against Con A-induced BALB/c mouse T cell after 48 hrs by CCK8 assay

Source:: ChEMBL

Assay data:34 Active, 21 Activity ≤ 1 µM, 44 Tested

AID:: 1675571

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 167557012.

Cytotoxicity against BALB/c mouse T cell assessed as reduction in cell viability after 48 hrs by CCK8 assay

Source:: ChEMBL

Assay data:36 Active, 5 Activity ≤ 1 µM, 44 Tested

AID:: 1675570

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 159752313.

Binding affinity to recombinant human N-terminal His-tagged Nur77 LBD (367 to 598 residues) expressed in Escherichia coli BL21(DE3) incubated for 30 secs by fluorescence quenching assay

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 4 group A member 1

Assay data:15 Active, 9 Activity ≤ 1 µM, 25 Tested

AID:: 1597523

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 159752514.

Antiinflammatory activity in human HepG2 cells assessed as inhibition of TNFalpha-induced IkappaBalpha degradation at 2 uM pretreated for 1 hr followed by TNFalpha addition and measured after 30 mins by Western blot analysis

Source:: ChEMBL

Assay data:9 Active, 25 Tested

AID:: 1597525

Summary Compounds, Active PubMed Citation

Select item 150860515.

Confirmatory qHTS for VERO E6 Cytotoxicity Assay: Counterscreen for SARS-CoV-2 CPE Assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:59 Active, 17 Activity ≤ 1 µM, 365 Tested

AID:: 1508605

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 145416116.

Cytotoxic activity against human HepG2 cells incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:27 Active, 16 Activity ≤ 1 µM, 27 Tested

AID:: 1454161

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 145416017.

Cytotoxic activity against human HeLa cells incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:26 Active, 13 Activity ≤ 1 µM, 27 Tested

AID:: 1454160

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 145415918.

Cytotoxic activity against human SGC7901 cells incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:26 Active, 18 Activity ≤ 1 µM, 27 Tested

AID:: 1454159

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 145415819.

Cytotoxic activity against human Bel7402 cells incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:27 Active, 16 Activity ≤ 1 µM, 27 Tested

AID:: 1454158

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 145415720.

Cytotoxic activity against human A549 cells incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:24 Active, 27 Tested

AID:: 1454157

Summary Compounds, Active PubMed Citation

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BioActivity

Chemical Probes (1)
BioAssays with compounds reported as validated chemical probes

Active Compounds (30)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (22)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (33)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (31)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (1)
BioAssays deposited by other experimentalists

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