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Agonist activity at 5-HT2CR (unknown origin) stably expressed in HEK293 cells measured after 1 hr by fluorescence based Ca2+/Fluo-4 assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryRelated BioAssays by Target
Agonist activity at 5-HT2AR (unknown origin) stably expressed in HEK293 cells measured after 1 hr by fluorescence based Ca2+/Fluo-4 assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Activation of human recombinant 5HT4E receptor transfected in tsA201 cells co-transfected with human APP695 assessed as increase in sAPPalpha secretion at 10 uM preincubated with 5HT4 receptor antagonist, GR-113808 followed by incubation with compound for 30 mins by western blot analysis relative to control
Assay data:2 Tested
Activation of human recombinant 5HT4E receptor transfected in tsA201 cells co-transfected with human APP695 assessed as increase in sAPPalpha secretion at 10 uM incubated for 30 mins by western blot analysis relative to control
Assay data:3 Tested
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
SummaryCompounds, Active
Bias factor, ratio of agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of cAMP production to agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment at 0.0001 to 10 uM
SummaryPubMed CitationRelated BioAssays by Target
Bias factor, ratio of agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as ERK1/2 phosphorylation at 0.0001 to 10 uM to agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment at 0.0001 to 10 uM
Agonist activity at human 5-HT1A receptor expressed in U2OS cells assessed as beta-arrestin recruitment incubated for 5 hrs by Tango assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human 5-HT1A receptor expressed in human U2OS cells assessed as beta-arrestin recruitment by measuring maximal efficacy at 0.0001 to 10 uM incubated for 5 hrs by Tango assay relative to control
Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation by measuring maximal efficacy at 0.0001 to 10 uM incubated for 15 mins by Alpha LISA assay relative to control
Assay data:1 Tested
Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production incubated for 40 mins by TR-FRET assay
Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP production by measuring maximal efficacy incubated for 40 mins by TR-FRET assay relative to control
Bias factor, ratio of agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as ERK1/2 phosphorylation at 0.0001 to 10 uM to agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as inhibition of cAMP production
Agonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as stimulation of ERK1/2 phosphorylation incubated for 15 mins by Alpha LISA assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of MIF tautomerase (unknown origin) using 4-HPP as substrate preincubated for 1 hr followed by substrate addition
Assay data:10 Tested
Agonist activity at human N and C-terminal 5HT2A receptor S159A mutant expressed in HEK293T cells cotransfected with Renilla luciferase assessed as fold decrease in potency of Galphaq dissociation by BRET assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human N and C-terminal 5HT2A receptor expressed in HEK293T cells cotransfected with Renilla luciferase assessed as fold decrease in potency of Galphaq dissociation by BRET assay
Agonist activity at human 5HT2A S159A mutant transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay relative to control
Assay data:8 Tested
Agonist activity at human 5HT2A S159A mutant transfected in HEK293T cells assessed as mini Galphaq recruitment measured for 2 hrs by luminescent assay
Assay data:8 Active, 4 Activity ≤ 1 µM, 8 Tested
Agonist activity at human 5HT2A S159A mutant transfected in HEK293T cells assessed as beta arrestin-2 recruitment measured for 2 hrs by luminescent assay relative to control
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