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Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic assay of human HDAC6 with custom peptide substrate
Assay data:5603 Tested
SummaryRelated BioAssays by Target
Enzymatic assay of human HDAC6 with commercial peptide substrate
Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltransferases
Assay data:968 Active, 24930 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Induction of tubulin acetylation in human HEK293T cells at 10 to 50 uM measured after 48 hrs by western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of NAT10-catalyzed RNA cytidine acetylation in human HeLa cells assessed as decrease in ac4C at helix 45 of 18S rRNA at 50 uM after 48 hrs by nucleotide resolution sequencing analysis
Inhibition of NAT10-catalyzed RNA cytidine acetylation in human HeLa cells assessed as decrease in ac4C level at 10 to 50 uM after 24 to 48 hrs by dot blot assay
Aggregation property of peptides assessed as colloidal aggregate formation at 25 uM by dynamic light scattering analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Aggregation property of the compound assessed as detergent sensitive inhibition of beta-lactamase AmpC at 33 to 100 uM
SummaryPubMed Citation
Redox activity of the compound assessed as H2O2 production at 250 uM in presence of DTT by horseradish peroxidase-phenol red counter screen based assay
Redox activity of the compound assessed as H2O2 producion at 250 uM by horseradish peroxidase-phenol red counter screen based assay
Thiol reactivity with CoA at 1 to 50 uM measured after 30 mins by DACM thiol consumption assay
Stability of the compound in DMSO-d6 solution assessed as drug degradation measured after 24 hrs by NMR analysis
Stability of the compound in DMSO-d6 solution assessed as discoloration to dark brown colour in presence of light
Assay data:2 Tested
Stability of the light-protected compound in aqueous buffer measured for 7 days
Inhibition of NAT10-catalyzed RNA cytidine acetylation in human HeLa cells assessed as decrease in ac4C at helix 45 of 18S rRNA at 50 uM after 4 days by UV-HPLC analysis
Inhibition of NAT10-catalyzed RNA cytidine acetylation in human HeLa cells assessed as decrease in ac4C at helix 34 of 18S rRNA at 50 uM after 4 days by UV-HPLC analysis
Inhibition of NAT10-catalyzed RNA cytidine acetylation in human HeLa cells assessed as decrease in ac4C level at 50 uM after 48 hrs by Northern blot assay
Inhibition of NAT10-catalyzed RNA cytidine acetylation in human HeLa cells assessed as decrease in ac4C level at 10 to 50 uM after 48 hrs by LC-MS assay
Binding affinity to recombinant NAT10 acetyltransferase domain (494 to 753 residues) (unknown origin) by isothermal titration calorimetry
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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