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Inhibition of cholesterol biosynthesis in human HuH7 cells preincubated for 14 hrs and followed by addition of 14C-acetate and measured after 2 hrs by TL method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Protac activity at CRBN/HMGCR in Insig-1/Insig-2 deficient Chinese hamster SRD15 cells assessed as HMGCR level at 1 uM after 16 hrs by immunoblotting analysis relative to control
Assay data:1 Tested
SummaryPubMed Citation
Effect on total neutral lipid in human HuH7 cells assessed change in lipid droplet count at 1 uM after 16 hrs by Oil Red O staining based method
Activation of TXNDC11 (unknown origin)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of SREBP2 pathway in mouse primary hepatocytes assessed as increase in HMGCR mRNA expression at 0.3 to 1 uM afer 16 hrs by quantitative real-time PCR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of SREBP2 pathway in mouse primary hepatocytes assessed as increase in LDLR mRNA expression at 0.3 to 1 uM afer 16 hrs by quantitative real-time PCR analysis
Protac activity at CRBN/HMGCR in human Huh7 cells assessed as induction of HMGCR degradation at 0.01 to 1 uM after 16 hrs by Western blot analysis
Inhibition of GFP-labelled HMGCR (unknown origin) expressed in lentivirus Chinese hamster SRD15 cells assessed as reduction in cholesterol biosynthesis at 1 uM after 16 hrs by Hoechst staining based laser-scanning microscopic method
Protac activity at human Flag-tagged CRBN/T7-tagged HMGCR expressed in Chinese hamster SRD15 cells transfected with HA-tagged ubiquitin assessed as increase in HMGCR immunoprecipitation 1 uM incubated for 16 hrs followed by pomalidomide addition addition and measured after 5 hrs in presence of MG132 by Western blot analysis
Protac activity at human Flag-tagged CRBN/T7-tagged HMGCR expressed in Chinese hamster SRD15 cells transfected with HA-tagged ubiquitin assessed as increase in HMGCR immunoprecipitation 1 uM incubated for 16 hrs followed by atorvastatin addition addition and measured after 5 hrs in presence of MG132 by Western blot analysis
Protac activity at human Flag-tagged CRBN/T7-tagged HMGCR expressed in Chinese hamster SRD15 cells transfected with HA-tagged ubiquitin assessed as increase in HMGCR immunoprecipitation 1 uM preincubated for 16 hrs followed by MG132 addition addition and measured after 5 hrs by Western blot analysis
Protac activity at human Flag-tagged CRBN/Myc-tagged HMGCR expressed in HEK293T cells assessed as induction of HMGCR immunoprecipitation 1 uM preincubated for 16 hrs followed by pomalidomide addition addition and measured after 5 hrs by Western blot analysis
Protac activity at human Flag-tagged CRBN/Myc-tagged HMGCR expressed in HEK293T cells assessed as induction of HMGCR immunoprecipitation 1 uM preincubated for 16 hrs followed by atorvastatin addition addition and measured after 5 hrs in presence of MG132 by Western blot analysis
Protac activity at human Flag-tagged CRBN/Myc-tagged HMGCR expressed in HEK293T cells assessed as induction of HMGCR immunoprecipitation at 1 uM preincubated for 16 hrs followed by MG132 addition addition and measured after 5 hrs in presence of MG132 by Western blot analysis
Effect on HMGCR mRNA expression in Chinese hamster SRD15 cells at 1 uM after 16 hrs by quantitative real-time PCR analysis
Protac activity at CRBN/HMGCR in Insig-1/Insig-2 deficient Chinese hamster SRD15 cells assessed as increase in ubiquitination level of HMGCR at 1 uM incubated for 4 hrs in presence of MG132 by Western blot analysis
Protac activity at CRBN/HMGCR in 5'-GGAAGUCGAAGACCAAGAU-3' siRNA transfected in Insig-1/Insig-2 deficient Chinese hamster SRD15 cells assessed as induction of HMGCR degradation at after 16 hrs by immunoblotting analysis
Protac activity at CRBN/HMGCR in 5'-GCAAGGCAGUGUAUAUUAU-3' siRNA transfected in Insig-1/Insig-2 deficient Chinese hamster SRD15 cells assessed as induction of HMGCR degradation at 1 uM after 16 hrs by immunoblotting analysis
Protac activity at CRBN/HMGCR in 5'-CCAGAAACUGAAGAUGAAA-3' siRNA transfected in Insig-1/Insig-2 deficient Chinese hamster SRD15 cells assessed as induction of HMGCR degradation at 1 uM after 16 hrs by immunoblotting analysis
Protac activity at human Flag-tagged CRBN YW/AA mutant /T7-tagged HMGCR transfected in Insig-1/Insig-2 deficient Chinese hamster SRD15 cells assessed as induction of HMGCR degradation at 0.01 to 1 uM after 16 hrs by immunoblotting analysis
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