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Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 800 secs by Fluo-4 AM-based fluorometric assay relative to control
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 800 secs by Fluo-4 AM-based fluorometric assay relative to control
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 800 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of Orai1 in Stim1-/1 and Stim2-/- MEF cells cells assessed as induction of store-operated calcium entry by measuring residual activity at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Assay data:1 Active, 1 Tested
Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring residual activity at 10 uM in presence of shTRPC1 preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA and 150 nM Ca2+ containing internal solution by patch clamp assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA by patch clamp assay relative to control
Assay data:2 Active, 2 Tested
Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry by measuring increase in slope at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry by measuring increase in AUC of calcium entry at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry by measuring increase in peak amplitude at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry by measuring increase in slope at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry by measuring increase in peak amplitude at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry by measuring increase in AUC of calcium entry at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring increase in slope at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring increase in peak amplitude at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring increase in AUC of calcium entry at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control
Antagonist activity at TRPM8 (unknown origin) expressed in HEK cells assessed as inhibition of menthol -mediated calcium increase at 10 uM by fura-2-based assay
Assay data:1 Active, 7 Tested
Antagonist activity at TRPV1 (unknown origin) expressed in HEK cells assessed as inhibition of capsaicin-induced calcium increase at 10 uM by fura-2-based assay
Assay data:2 Active, 7 Tested
Antagonist activity at TRPM8 in C57/BL6 mouse cerebellar granule cells assessed as inhibition of KCl-induced voltage dependent calcium entry at 10 uM by fura-2-based assay
Assay data:7 Tested
Antagonist activity at TRPV1 in C57/BL6 mouse cerebellar granule cells assessed as inhibition of KCl-induced voltage dependent calcium entry at 10 uM by fura-2-based assay
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