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Antiviral Assay from US Patent US20240034730: "PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryRelated BioAssays by Target
Inhibition of SARS-CoV-2 RdRP using ATP substrate preincubated with compound for 30 mins followed by substrate addition and measured after 30 mins by Alphascreen microplate reader analysis
Assay data:2 Active, 2 Tested
Selectivity index, ratio of CC50 for african green monkey Vero E6 cells to IC50 for antiviral activity against SARS-CoV-2 NRC-03-nhCoV infected in african green monkey Vero E6 cells
Assay data:4 Tested
Summary
Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by MTT assay
Antiviral activity against SARS-CoV-2 NRC-03-nhCoV infected in african green monkey Vero E6 cells assessed as inhibition of virus-induced cytopathic effect measured after 72 hrs by crystal violet staining based assay
Assay data:1 Active, 4 Tested
Antiviral activity against Sindbis virus infected in human Huh-7 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
Assay data:12 Tested
Antiviral activity against Zika virus Mr776 infected in human Huh-7 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 12 Tested
Antiviral activity against Yellow fever virus 17D infected in human Huh-7 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
Assay data:1 Active, 12 Tested
Antiviral activity against RSV infected in human HEL 299 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 12 Tested
Antiviral activity against HCoV-NL63 infected in human Huh-7 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
Antiviral activity against HCoV-OC43 infected in human HEL 299 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
Antiviral activity against HCoV-229E infected in human HEL 299 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
Cytotoxicity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 12 Tested
Cytotoxicity against human HEL 299 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay
Assay data:1 Active, 13 Tested
Cytotoxicity against HEK293T cells at 0.1 uM assessed as reduction in cell viability by CellTiter-Glo assay
Assay data:1 Tested
Antiviral activity against SARS-CoV-2 infected in HEK293T cells expressing ACE2/TMPRSS2 assessed as reduction in virus-induced cytopathic effect at 0.1 uM measured after 48 hrs by cellular ATP assay
Cytotoxicity against HEK293T cells at 10 uM assessed as reduction in cell viability by CellTiter-Glo assay
Selectivity index, ratio of CC50 for african green monkey Vero cells to EC50 for Severe acute respiratory syndrome coronavirus 2
Assay data:16 Tested
Cytotoxicity against african green monkey Vero cells
Antiviral activity against Severe acute respiratory syndrome coronavirus 2 infected in Vero cells
Assay data:12 Active, 17 Tested
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