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High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
In vivo inhibition of sEH in zymosan-induced peritonitis CD-1 mouse model assessed as increase in 14,15-EET levels in peritoneal exudates at 10 mg/kg, ip administered 30 mins prior to zymosan challenge and measured after 30 mins to 4 hrs by LC-MS/MS analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
In vivo inhibition of sEH in zymosan-induced peritonitis CD-1 mouse model assessed as increase in 11,12-EET levels in peritoneal exudates at 10 mg/kg, ip administered 30 mins prior to zymosan challenge and measured after 30 mins to 4 hrs by LC-MS/MS analysis
Inhibition of human recombinant sEH assessed as enzyme residual activity at 1 uM using PHOME as substrate preincubated for 1 min followed by substrate addition and measured after 60 mins by fluorescence based analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human sEH using cyano(6-methoxynaphthalen-2-yl)methyl((3-phenyloxiran-2-yl)methyl)carbonate as a substrate assessed as reduction in 6-methoxynaphthaldehyde formation by fluorescence microplate reader assay
Assay data:14 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US10383835: "Treatment of inflammatory disorders in non-human mammals"
Assay data:25 Active, 6 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Mtb EHB Inhibition Assay from Article 10.1016/j.jmb.2008.06.030: "The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor."
Assay data:13 Active, 8 Activity ≤ 1 µM, 19 Tested
Inhibition of sEH (unknown origin) expressed in baculovirus expression system incubated for 1 hr
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for 30 mins by fluorescence based assay
Assay data:24 Active, 2 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 26 Tested
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human sEH using epoxy flour 7 as substrate measured after 30 mins by cell-based fluorescence assay
Assay data:13 Active, 4 Activity ≤ 1 µM, 14 Tested
High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activity
Assay data:519 Active, 370620 Tested
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
A screen for small molecules that modulate mitochondrial supercomplex formation
Assay data:101 Active, 2017 Tested
Inhibition of human recombinant MEST T579B (2 to 335 amino acids) expressed in Sf9 cell membranes assessed as reduction in glycerol 3-phosphate acyltransferase activity using [3H]-glycerol 3-phosphate and palmitoyl CoA incubated for 60 mins by scintillation counting assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of human recombinant MEST T579B (2 to 335 amino acids) expressed in Sf9 cell membranes assessed as reduction in glycerol 3-phosphate acyltransferase activity at 0.3 uM using [3H]-glycerol 3-phosphate and palmitoyl CoA incubated for 60 mins by scintillation counting assay relative to control
Inhibition of human recombinant MEST T579B (2 to 335 amino acids) expressed in Sf9 cell membranes assessed as reduction in glycerol 3-phosphate acyltransferase activity at 1 uM using [3H]-glycerol 3-phosphate and palmitoyl CoA incubated for 60 mins by scintillation counting assay relative to control
Inhibition of human recombinant MEST T579B (2 to 335 amino acids) expressed in Sf9 cell membranes assessed as reduction in glycerol 3-phosphate acyltransferase activity at 3 uM using [3H]-glycerol 3-phosphate and palmitoyl CoA incubated for 60 mins by scintillation counting assay relative to control
Inhibition of human recombinant MEST T579B (2 to 335 amino acids) expressed in Sf9 cell membranes assessed as reduction in glycerol 3-phosphate acyltransferase activity at 10 uM using [3H]-glycerol 3-phosphate and palmitoyl CoA incubated for 60 mins by scintillation counting assay relative to control
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