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Substrate activity at OATP in human patient derived GBM cells assessed as protein-mediated drug uptake at 1 uM preincubated with sodium tauro-cholic acid for 30 mins followed by compound treatment measured after 1 hr by Hoechst staining based fluorescence microscopy
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at OATP in human patient derived GBM cells assessed as protein-mediated drug uptake at 1 uM preincubated with 3,4-DHB for 1 hr followed by compound treatment measured after 1 hr by Hoechst staining based fluorescence microscopy
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Substrate activity at OATP in patient-derived GBM cells assessed as compound uptake at 1 uM incubated for 1 hr in presence of OATP activator 3,4-Dihydroxybenzoic acid by fluorescence microscopic analysis
Substrate activity at OATP in patient-derived GBM cells assessed as compound uptake at 1 uM incubated for 1 hr in presence of OATP inhibitior sodium taurocholic acid by fluorescence microscopic analysis
Human OATP1A2 (SLCO family of organic anion transporting polypeptides)
Assay data:3 Active, 3 Tested
Inhibition of human OATP1A2 expressed HEK293 cells assessed as inhibition of [3H]sulfobromophthalein uptake by liquid scintillation counting
Cellular uptake in Xenopus oocytes cells assessed as OATP1A2 (unknown origin)-mediated drug uptake
Cellular uptake in HEK293 cells assessed as bovine OATP1A2-mediated drug uptake at 50 uM in presence of methotrexate
Cellular uptake in HEK293 cells assessed as bovine OATP1A2-mediated drug uptake at 50 uM in presence of rifampicin
Cellular uptake in HEK293 cells assessed as bovine OATP1A2-mediated drug uptake at 50 uM in presence of bromosulfophthalein
Cellular uptake in HEK293 cells assessed as bovine OATP1A2-mediated drug uptake at 50 uM in presence of taurocholate
Cellular uptake in HEK293 cells assessed as bovine OATP1A2-mediated drug uptake at 50 nM in presence of taurocholate
Cellular uptake in HEK293 cells assessed as bovine OATP1A2-mediated drug uptake at 5 uM at pH 7.4 after 1 min
Cellular uptake in HEK293 cells assessed as bovine OATP1A2-mediated drug uptake at 5 uM at pH 6 after 1 min
Cellular uptake in HEK293 cells assessed as bovine low affinity site of OATP1A2-mediated drug uptake at 50 uM at pH 7.4 after 1 min
Cellular uptake in HEK293 cells assessed as bovine low affinity site of OATP1A2-mediated drug uptake at 50 uM at pH 6 after 1 min
Cellular uptake in HEK293 cells assessed as bovine high affinity site of OATP1A2-mediated drug uptake at 50 nM at pH 7.4 after 1 min
Cellular uptake in HEK293 cells assessed as bovine high affinity site of OATP1A2-mediated drug uptake at 50 nM at pH 6 after 1 min
Cellular uptake in HEK293 cells assessed as bovine high affinity site of OATP1A2-mediated drug uptake at 0.5 to 100 uM after 1 min by Eadie-Hofstee plot analysis
Cellular uptake in HEK293 cells assessed as human OATP1A2-mediated drug uptake at 0.05 uM after 1 min by Eadie-Hofstee plot analysis
Assay data:2 Tested
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