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Binding affinity towards human SLC29A1 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:20 Active, 4 Activity ≤ 1 µM, 1115 Tested
SummaryRelated BioAssays by Target
Inhibition of ENT1 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human recombinant ENT1 assessed as inhibition of [3H] uridine transport
Assay data:2 Tested
Inhibition of human ENT1 transfected in nucleoside transporter-deficient pig PK-15 cells assessed as inhibition of [3H]-uridine uptake by liquid scintillation counter analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human ENT1 transfected in nucleoside transporter-deficient pig PK-15 cells assessed as inhibition of [3H]-adenosine uptake by liquid scintillation counter analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of the equilibrative nucleoside transporter (ENT1, SLC29A1) as assessed by GPCR-mediated changes in cell morphology using the impedance-based transporter activity through receptor activation (TRACT) assay (PubChem AID: 1745861)
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
Determination of Adenosine Transport Activity from US Patent US10377746: "Indolin-2-one derivatives"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Flow Cytometric Assay from Article 10.1021/jm070311l: "Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors."
Assay data:33 Active, 4 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 33 Tested
Impedance-based transporter assay for SLC29A1 using U2OS cells
Assay data:5 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Substrate activity at ENT1 in human BXPC-3 cells assessed as inhibition of cell growth pretreated with ENT1 inhibitor nitrobenzylthioinosine for 5 mins measured after 72 hrs by SRB assay
Assay data:4 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of mouse ENT1 expressed in mammalian cells assessed as reduction in [2,8-H]adenosine uptake by liquid scintillation counting method
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Human Equilibrative nucleoside transporter 1 (SLC29 family)
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Drug transport in human CCRF-CEM cells assessed as ENT1-mediated uptake after 5 secs by Michaelis-Menten equation analysis
Drug transport in Xenopus laevis oocytes assessed as recombinant human ENT1-mediated uptake up to 1 mM by Michaelis-Menten equation analysis
Drug transport in Xenopus laevis oocytes assessed as recombinant human ENT1-mediated uptake up to 1 mM measured per 2 mins by Michaelis-Menten equation analysis
Drug transport in human CCRF-CEM cells assessed as ENT1-mediated uptake at 10 uM after 1 to 60 mins by liquid scintillation counting analysis
Assay data:2 Active, 2 Tested
Drug transport in human CCRF-CEM cells assessed as ENT1-mediated uptake measured per 10'6 cells after 5 secs by Michaelis-Menten equation analysis
Binding affinity to recombinant human ENT1 expressed in Saccharomyces cerevisiae assessed as inhibition of [3H]-uridine transport after 15 mins by scintillation counting analysis
Assay data:3 Tested
Drug transport in yeast assessed as recombinant human ENT1-mediated uptake at 1 uM measured over 2 to 60 mins by scintillation counting analysis in absence of uridine
Assay data:1 Active, 1 Tested
Drug transport in yeast assessed as recombinant human ENT1-mediated uptake at 1 uM measured over 2 to 60 mins by scintillation counting analysis in presence of uridine
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