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Prostanoid EP1 Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to EP1 receptor (unknown origin) assessed as inhibition constant
Antagonist activity at human EP1 receptor transfected in CHO/Galpha16 cells preincubated for 15 mins followed by PGE2 addition by calcium flux assay
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human EP1 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at EP1 receptor (unknown origin)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human EP1 receptor assessed as inhibition constant
Assay data:1 Active, 1 Tested
Cell Based Assay from US Patent US9422273: "Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response"
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9181187: "Therapeutic agent for urinary excretion disorder"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Radioligand Binding from US Patent US9156810: "Treatment of inflammatory bowel disease"
Assay data:20 Active, 17 Activity ≤ 1 µM, 22 Tested
In Vitro Binding Assay from US Patent US9000043: "Phenoxyethoxy compounds"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
In Vitro Binding Assay from US Patent US8962659: "Phenoxyethyl piperidine compounds"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
In Vitro Binding Assay from US Patent US8933098: "Dimethyl-benzoic acid compounds"
Cell Response Assay from US Patent US8680120: "Indole derivative or pharmaceutically acceptable salt thereof"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Prostanoid EP Receptor Binding Assay from Article 10.1016/j.bmc.2009.08.007: "Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists."
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
Prostanoid EP1 Eurofins-Panlabs radioligand binding assay
Assay data:3 Tested
Assay data:2 Tested
PRESTO-Tango GPCRome screening (PTGER1)
Displacement of [3H]prostaglandin E2 from full-length recombinant human EP1 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
Agonist activity at human EP1 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay
Assay data:1 Active, 6 Tested
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