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Inhibition of C-terminal His6-tagged recombinant mouse DNA polymerase iota using poly(dA)/oligo(dT)18 and [3H]dTTP as template-primer and nucleotide substrate after 60 mins
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human DNA polymerase iota preincubated for 15 mins followed by replicating non-damaged DNA substrate addition measured after 30 mins in presence of dCTP and dGTP by radioactive gel-based primer extension assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant DNA polymerase iota expressed in Baculovirus expression system using TAMRA/BHQ-2-labeled primer/template measured at 2 to 6 mins by reporter-strand displacement assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins
qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds
Assay data:1154 Active, 13 Activity ≤ 1 µM, 1503 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of mouse recombinant C-terminal-His6-tagged DNA polymerase iota assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins
Assay data:3 Tested
Inhibition of C-terminal His6-tagged mouse DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins
Assay data:2 Active, 2 Tested
qHTS for Inhibitors of Polymerase Iota: Summary
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for Inhibitors of Polymerase Iota
Assay data:4029 Active, 1388 Activity ≤ 1 µM, 391277 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Activity of mouse DNA polymerase iota using dTTP substrate at 15 uM by Lineweaver-Burke plot
Activity of mouse DNA polymerase iota using dTTP substrate at 10 uM by Lineweaver-Burke plot
Activity of mouse DNA polymerase iota using dTTP substrate at 5 uM by Lineweaver-Burke plot
Activity of mouse DNA polymerase iota using poly(dA/oligo(dT) substrate at 15 uM by Lineweaver-Burke plot
Activity of mouse DNA polymerase iota using poly(dA/oligo(dT) substrate at 10 uM by Lineweaver-Burke plot
Activity of mouse DNA polymerase iota using poly(dA/oligo(dT) substrate at 5 uM by Lineweaver-Burke plot
Inhibition of mouse DNA polymerase iota at 100 uM
Inhibition of mouse DNA polymerase iota
Assay data:2 Tested
Inhibition of human DNA polymerase iota at 200 uM
Inhibition of human DNA polymerase iota at 100 uM
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