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Human protein phosphatase methylesterase 1 (S33: Prolyl aminopeptidase)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of FP-Rh probe binding to PME-1 (unknown origin) at 685 nM incubated for 30 mins followed by FP-Rh probe addition measured after 30 mins by ABPP gel-based assay
Inhibition of FP-Rh probe binding to PME-1 (unknown origin) at 100 uM incubated for 30 mins followed by FP-Rh probe addition measured after 30 mins by ABPP gel-based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Ppme1 in mouse Neuro2a cells at 3 nM after 4 hrs by ABPP-SILAC assay
Assay data:3 Tested
Inhibition of PME1 binding to FP-rhodamine in human MDA-MB-231 cells after 30 mins by fluorescence polarization activity-based protein profiling assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PME1-based PP2A deethylation in human HEK293T cells at 50 uM after 3 hrs by Western blot analysis
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome at 20 uM after 30 mins by fluorescence polarization activity-based protein profiling assay relative to control
Assay data:8 Tested
Inhibition of PME1 binding to FP-rhodamine in human HEK293T cells after 45 mins by fluorescence polarization activity-based protein profiling assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Irreversible inhibition of PME1 binding to FP-rhodamine in human HEK293T cells at 50 uM after 30 mins by gel filtration chromatographic analysis
Binding affinity to PME1 assessed as compound-enzyme serine nuclephile adduct formation by MS analysis
Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profiling assay
Assay data:9 Active, 2 Activity ≤ 1 µM, 11 Tested
Inhibition of PME1 binding to FP-rhodamine in HEK293T cells after 1 hr by fluorescence polarization activity-based protein profiling assay
Inhibition of PME1 binding to FP-biotin in [12C][14N]-lysine, arginine and [13C6][15N2]-lysine, arginine labeled HEK293T cells at 20 uM after 1 hr by isotopic activity-based protein profiling-MudPIT assay
Inhibition of PME1 overexpressed in HEK293T cells assessed as reduction in demethylated PP2A level at 20 uM after 1 hr by Western blot analysis relative to control
Assay data:2 Tested
Inhibition of PME1 overexpressed in HEK293T cells assessed as increase in methylated PP2A level at 20 uM after 1 hr by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of PME1 expressed in untransfected HEK293T cells assessed as reduction in demethylated PP2A level at 20 uM after 1 hr by Western blot analysis
Inhibition of PME1 expressed in untransfected HEK293T cells assessed as reduction in demethylated PP2A level at 500 nM after 1 hr by Western blot analysis
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA2: LCMS-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in vitro
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA2: LCMS-based cell-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in situ
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA1: LCMS-based cell-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in situ
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