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Histamine H3 Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity towards human HRH3 in an in vitro assay with cellular components measured by scintillation counting
Assay data:41 Active, 7 Activity ≤ 1 µM, 993 Tested
Assay data:23 Active, 11 Activity ≤ 1 µM, 927 Tested
Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from Sprague-Dawley rat brain membrane histamine H3 receptor assessed as inhibition constant incubated for 30 mins by liquid scintillation counting analysis
Assay data:21 Active, 21 Activity ≤ 1 µM, 22 Tested
Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from recombinant human histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition constant incubated for 30 mins by liquid scintillation analysis
Assay data:23 Active, 8 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from recombinant human histamine H3 receptor expressed in CHO-K1 cells at 300 nM incubated for 30 mins by liquid scintillation analysis relative to control
Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from Sprague-Dawley rat brain membrane histamine H3 receptor at 300 nM incubated for 30 mins by liquid scintillation counting analysis relative to control
Assay data:2 Tested
Inverse agonist activity at recombinant human histamine H3 receptor expressed in CHO-K1 cells preincubated for 10 mins followed by [35S]GTPgammaS addition and measured after 60 mins by TopCount NXT based scintillation analysis
Assay data:17 Active, 11 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of imetit-stimulation ERK1/2 phosphorylation by ELISA analysis
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Inverse agonist activity at recombinant human histamine H3 receptor expressed in CHO-K1 cells assessed as maximal efficacy preincubated for 10 mins followed by [35S]GTPgammaS addition and measured after 60 mins by TopCount NXT based scintillation analysis relative to control
Assay data:3 Tested
Antagonist potency at recombinant human histamine H3 receptor expressed in CHO cells assessed as inhibition of histamine stimulated GTPgammaS binding
Assay data:1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human H3 receptor assessed as inhibition constant incubated for 90 mins by scintillation counting method
Assay data:10 Active, 2 Activity ≤ 1 µM, 15 Tested
Inhibition of human H3 receptor incubated for 90 mins by scintillation counting method relative to control
Inhibition of human H3 receptor at 1 uM incubated for 90 mins by scintillation counting method relative to control
Assay data:6 Tested
Inhibition of human H3 receptor at 10 uM incubated for 90 mins by scintillation counting method relative to control
Assay data:15 Tested
Inhibition of human H3 receptor assessed as inhibition constant incubated for 90 mins by scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human H3R expressed in HEK293 cells membrane
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of histamine H3 receptor (unknown origin) at 10 uM
Antagonist activity at H3R (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Determination of Ki Value at Human and Rat Histamin-3 Receptor from US Patent US11622967: "Method of treatment with histamine-3 receptor inverse agonist"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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