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Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CYP2D6 (unknown origin)
Assay data:3 Tested
Assay data:1 Active, 1 Tested
Time-dependent inhibition of CYP2D6 (unknown origin)
Inhibition of CYP2D6 in human liver microsomes incubated for 10 mins in presence of NADPH by LC/MS/MS analysis
Assay data:2 Tested
Reversible inhibition of CYP2D6 in human liver microsomes assessed as residual activity at 5 uM using dextromethorphan as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Inhibition of human CYP2D6
Inhibition of CYP2D6 in human liver microsomes
Inhibition of CYP2D6 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC/MS/MS analysis
Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate assessed as reduction in substrate hydroxylation incubated for 5 mins in presence of beta-NADPH measured by LC-MS/MS analysis
Assay data:1 Active, 2 Tested
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH by LC-MS/MS analysis
Inhibition of CYP2D6 (unknown origin) at 1 uM relative to control
Inhibition of CYP2D6 (unknown origin) by fluorescence based assay
Inhibition of human CYP2D6 at 10 uM relative to control
Assay data:7 Active, 11 Tested
Inhibition of CYP2D6 in human liver microsomes using probe substrate at 0.1 to 100 uM in presence of NADPH
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