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TLR7/8/9 Inhibition Reporter Assays from US Patent US11912703: "6-azaindole compounds"
Assay data:399 Active, 121 Activity ≤ 1 nM, 396 Activity ≤ 1 µM, 400 Tested
SummaryRelated BioAssays by Target
HEK Reporter Assay from US Patent US20240033370: "ANTI-PD-L1 IMMUNOCONJUGATES, AND USES THEREOF"
Assay data:60 Active, 40 Activity ≤ 1 µM, 60 Tested
Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electrochemiluminescence immunoassay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Agonist activity at TLR7 (unknown origin) expressed in human U2OS cells assessed as induction of NF-kappaB driven TNFalpha production by luciferase reporter assay
Assay data:1 Active, 1 Tested
Agonist activity at TLR7 in human whole blood assessed as induction of IL-12p70 production after 20 hrs by electrochemiluminescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at TLR7 in human whole blood assessed as induction of IL-10 production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of IFN-gamma production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of IL-1beta production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of TNFalpha production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of IFNalpha production after 20 hrs by electrochemiluminescence assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at TLR7 in human U2OS cells
Agonist activity at TLR7 in human PBMC assessed as TFN-alpha production after 24 hrs by electrochemiluminescence assay
Assay data:14 Active, 4 Activity ≤ 1 µM, 19 Tested
Agonist activity at TLR7 in human PBMC assessed as IFN-alpha production after 24 hrs by electrochemiluminescence assay
Assay data:17 Active, 6 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Agonist activity at TLR7 in cryopreserved human PBMC assessed as IFN-alpha production after 24 hrs by MSD assay
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 18 hrs by quanti-blue reagent based analysis
Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 24 hrs by quanti-blue reagent based analysis
Agonist activity at TLR7 (unknown origin)
Assay data:15 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 17 Tested
Agonist activity at human TLR7 transfected in HEK293 cells incubated for 6 hrs by luciferase based analysis
Agonist activity at recombinant human TLR7 transfected in HEK293 cells assessed as induction of SEAP production incubated overnight by SEAP reporter gene based assay
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
Agonist activity at human TLR7 in HEK-Blue hTLR7 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assay
Assay data:37 Active, 18 Activity ≤ 1 µM, 39 Tested
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