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HEK Reporter Assay from US Patent US20240033370: "ANTI-PD-L1 IMMUNOCONJUGATES, AND USES THEREOF"
Assay data:60 Active, 40 Activity ≤ 1 µM, 60 Tested
SummaryRelated BioAssays by Target
Agonist activity at human TLR8 expressed in HEK293 cells by reporter gene assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human TLR8 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electrochemiluminescence immunoassay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Agonist activity at TLR8 (unknown origin) expressed in human U2OS cells by luciferase reporter assay
Assay data:1 Tested
Agonist activity at TLR8 in human PBMC cells assessed as increase in IL-12 level incubated for 24 hrs by ELISA
Agonist activity at TLR8 in human PBMC cells assessed as increase in TNF-alpha level incubated for 24 hrs by ELISA
Agonist activity at human TLR8 transfected in HEK293T cells co-transfected with NF-kappaB and renilla assessed as increase in TLR8-induced NF-kappaB activity at 0.4 to 10 uM incubated for 48 hrs by Dual-luciferase reporter gene assay
Assay data:1 Active, 1 Tested
Agonist activity at human TLR8 in HEK-Blue hTLR8 cells incubated for 24 hrs by quanti-blue reagent based analysis
Agonist activity at human TLR8 transfected in HEK293 cells incubated for 6 hrs by luciferase based analysis
Agonist activity at human TLR8 transfected in HEK293 cells assessed as induction of SEAP production incubated overnight
Assay data:8 Active, 1 Activity ≤ 1 µM, 14 Tested
Agonist activity at human TLR8 in HEK-Blue hTLR8 cells assessed as induction of SEAP production using nitrophenyl phosphate as substrate incubated for 20 hrs by microplate reader analysis
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Agonist activity at human TLR8 (27 to 287 residues) in HEK-Blue hTLR8 cells assessed as induction of NFkappaB by SEAP reporter gene based spectrophotometry assay
Assay data:10 Active, 3 Activity ≤ 1 µM, 17 Tested
Agonist activity at TLR8 (unknown origin)
Assay data:14 Active, 9 Activity ≤ 1 µM, 19 Tested
Agonist activity at human TLR8 in HEK-Blue hTLR8 cells assessed as activation of NFkappaB by SEAP reporter gene based spectrophotometry assay
Assay data:20 Active, 4 Activity ≤ 1 µM, 22 Tested
Agonist activity at human TLR8 expressed in HEK293 cells assessed as activation of NFkappaB incubated for 18 to 24 hrs by SEAP reporter gene based assay
Assay data:4 Tested
Agonist activity at human TLR8 receptor
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Activation of TLR8 (unknown origin)
Inhibition of human TLR8
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Agonist activity at human TLR8
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Agonist activity in TLR8 (unknown origin) expressed in HEK293 cells assessed as induction of NF-kappa activation
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
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