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HEK Reporter Assay from US Patent US20240033370: "ANTI-PD-L1 IMMUNOCONJUGATES, AND USES THEREOF"
Assay data:60 Active, 40 Activity ≤ 1 µM, 60 Tested
SummaryRelated BioAssays by Target
Agonist activity at human TLR8 expressed in HEK293 cells by reporter gene assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human TLR8 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electrochemiluminescence immunoassay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electrochemiluminescence immunoassay
Agonist activity at TLR8 (unknown origin) expressed in human U2OS cells by luciferase reporter assay
Assay data:1 Tested
Agonist activity at TLR7 (unknown origin) expressed in human U2OS cells assessed as induction of NF-kappaB driven TNFalpha production by luciferase reporter assay
Assay data:1 Active, 1 Tested
Agonist activity at TLR7 in human whole blood assessed as induction of IL-12p70 production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of IL-10 production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of IFN-gamma production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of IL-1beta production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of TNFalpha production after 20 hrs by electrochemiluminescence assay
Agonist activity at TLR7 in human whole blood assessed as induction of IFNalpha production after 20 hrs by electrochemiluminescence assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at TLR7 in human U2OS cells
Agonist activity at TLR7 in human PBMC assessed as TFN-alpha production after 24 hrs by electrochemiluminescence assay
Assay data:14 Active, 4 Activity ≤ 1 µM, 19 Tested
Agonist activity at TLR7 in human PBMC assessed as IFN-alpha production after 24 hrs by electrochemiluminescence assay
Assay data:17 Active, 6 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Agonist activity at TLR7 in cryopreserved human PBMC assessed as IFN-alpha production after 24 hrs by MSD assay
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
Agonist activity at TLR8 in human PBMC cells assessed as increase in IL-12 level incubated for 24 hrs by ELISA
Agonist activity at TLR8 in human PBMC cells assessed as increase in TNF-alpha level incubated for 24 hrs by ELISA
Agonist activity at human TLR8 transfected in HEK293T cells co-transfected with NF-kappaB and renilla assessed as increase in TLR8-induced NF-kappaB activity at 0.4 to 10 uM incubated for 48 hrs by Dual-luciferase reporter gene assay
Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 18 hrs by quanti-blue reagent based analysis
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