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Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Inhibition of CYP2C8 (unknown origin)
Inhibition of CYP2C9 (unknown origin)
Assay data:1 Active, 3 Tested
Inhibition of CYP2C19 (unknown origin)
Assay data:3 Tested
Assay data:1 Active, 1 Tested
Inhibition of CYP2C9 in human liver microsomes incubated for 10 mins in presence of NADPH by LC/MS/MS analysis
Assay data:2 Tested
Reversible inhibition of CYP2C19 in human liver microsomes assessed as residual activity at 5 uM using (S)-mephenytoin as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Reversible inhibition of CYP2C9 in human liver microsomes assessed as residual activity at 5 uM using diclofenac as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Assay data:4 Tested
Reversible inhibition of CYP2C8 in human liver microsomes assessed as residual activity at 5 uM using amodiaquine as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Inhibition of human CYP2C8
Assay data:1 Active, 2 Tested
Inhibition of human CYP2C9
Assay data:2 Active, 2 Tested
Inhibition of human CYP2C19
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
Assay data:8 Active, 1 Activity ≤ 1 µM, 9 Tested
Inhibition of CYP2C19 in human liver microsomes
Inhibition of CYP2C9 in human liver microsomes
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