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Binding affinity to CypB (unknown origin)
Assay data:1 Active, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of CypD (unknown origin)
Assay data:2 Active, 2 Tested
Inhibition of CypC (unknown origin)
Assay data:2 Tested
Inhibition of CypB (unknown origin)
Inhibition of CypA (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to CypD (unknown origin)
Assay data:3 Active, 3 Tested
Binding affinity to CypA (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Surface Plasmon Resonance (SPR) Assay from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Isothermal Titration Calorimetry (ITC) from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:8 Active, 4 Activity ≤ 1 µM, 21 Tested
Inhibition of CypA (unknown origin) upto 20 uM
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CypA (unknown origin) assessed as inhibition constant by isomer specific proteolysis assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to His6-tagged CypA (unknown origin) expressed in Escherichia coli BL21 (DE3) incubation at 1 hr by multimode plate reader
Assay data:6 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US9090657: "Compound and methods for its production"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Enzymatic Assay from US Patent US8901295: "Inhibitors of cyclophilins and uses thereof"
Assay data:11 Active, 3 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Surface Plasmon Resonance Assay from Article 10.1021/cc0501561: "Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay."
Assay data:10 Active, 5 Activity ≤ 1 µM, 16 Tested
PPIase Assay from Article 10.1021/bi9007287: "Isoform-specific inhibition of cyclophilins."
Assay data:4 Active, 2 Activity ≤ 1 µM, 9 Tested
PPIase Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:1 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
ESI-MS Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:6 Tested
Enzymatic Assay from US Patent US9975902: "Compounds for the inhibition of cyclophilins and uses thereof"
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
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