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Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of Kv1.5 channel (unknown origin) upto 10000 nM
Inhibition of Kv1.5 (unknown origin) at 10 uM
Inhibition of Kv1.5 (unknown origin) by patch clamp method
SummaryPubMed CitationRelated BioAssays by Target
Activation of human Kv1.2 expressed in HEK293T cells at 10 uM by patch clamp electrophysiology method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Effect on rat Kv1.6 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Effect on rat Kv1.5 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Effect on rat Kv1.4 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Effect on human Kv1.3 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Effect on rat Kv1.2 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Effect on rat Kv1.1 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Inhibition of human Kv1.3 expressed in HEK293 cells assessed as inhibition of tetracyclin induced current at 30 uM at holding potential of -80 mV by patch clamp method relative to control
Assay data:21 Tested
Inhibition of human Kv1.3 expressed in HEK293 cells assessed as inhibition of tetracyclin induced current at holding potential of -80 mV by patch clamp method
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human Kv1.3 expressed in HEK293 cells assessed as inhibition of tetracyclin induced current at 1 uM at holding potential of -80 mV by patch clamp method relative to control
Assay data:20 Tested
Inhibition of human Kv1.5 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at 10 uM at +40mV holding potential by two-electrode voltage clamp assay
Inhibition of human hKv1.5 at 30 uM comprehensive in-vitro proarrhythmia assay
Patch-Clamp Assay from US Patent US10822345: "KV1.3 inhibitors and their medical application"
Assay data:63 Active, 44 Activity ≤ 1 µM, 63 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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