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Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay from US Patent US20240043404: "APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES"
Assay data:372 Active, 356 Activity ≤ 1 nM, 372 Activity ≤ 1 µM, 372 Tested
SummaryRelated BioAssays by Target
HTRF (BCL2)
Assay data:1 Tested
Inhibition of his-tagged human recombinant Bcl-2 expressed in Escherichia coli /human Bim measured for 60 mins by by TR-FRET based LanthaScreen Eu-Kinase binding assay
Assay data:29 Active, 28 Activity ≤ 1 µM, 29 Tested
Inhibition of BCL-2 (unknown origin) using FITC-Ahx-GQVGRQLAIIGDDINR-CONH2 as substrate incubated for 4 hrs by fluorescence polarization competition assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of fluorescent-labeled BID-BH3 peptide binding to Bcl-2 (unknown origin) by fluorescence polarization assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant Bcl-2 (unknown origin) by fluorescence polarization-based competitive binding assay
Assay data:1 Active, 1 Tested
Inhibition of Bcl-2 (unknown origin)
Inhibition of Bcl-2 (unknown origin) by ELISA analysis
Binding affinity to recombinant Bcl-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by MST analysis
Binding affinity to Bcl-2 (unknown origin) by ELISA analysis
Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant by competitive fluorescence polarization assay
Assay data:2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to Bcl-2 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Flu-BakBH3 binding to GST-tagged Bcl-2 (unknown origin) preincubated for 10 mins followed by Flu-BakBH3 addition and measured after 30 mins by competitive fluorescence polarization assay
Inhibition of BH3 peptide binding to Bcl-2 (unknown origin)
Inhibition of Flu-BakBH3 binding to Bcl-2 (unknown origin) assessed as inhibition constant by competitive fluorescence polarization assay
Inhibition of Flu-BakBH3 binding to recombinant GST-tagged Bcl-2 (unknown origin) incubated for 30 mins by competitive fluorescence polarization assay
Binding affinity to recombinant His-tagged human Bcl-2 expressed in Escherichia coli assessed as inhibition constant by SPR analysis
Displacement of biotinylated Bim peptide from Bcl-2 (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
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