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Inhibition of human partial length wild type MLK1 expressed in bacterial system at 1 uM by KINOMEscan analysis relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Enzymatic assay (Invitrogen)) EUB0000138c MAP3K9
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of MLK1 (unknown origin) at 1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human MLK1 at 1 uM relative to control
Inhibition of MLK1 (unknown origin) at 1 uM
MLK1 DiscoveRx kinase panel
MLK1(h) Kinase panel
MLK1(h) Millipore kinase panel
Inhibition of recombinant human MLK1 (134 to 414 residues) using casein as substrate incubated for 40 mins in presence of [gamma-33ATP by scintillation counting based radiometry assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human MLK1 (V88 to W426 residues) expressed in bacterial expression system assessed as residual activity at 500 nM by KINOMEscan assay relative to control
Assay data:2 Tested
Inhibition of human recombinant MLK1 assessed as reduction in substrate phosphorylation at 50 nM using ATP and Ulight-FLGFTYVAP as substrate incubated for 60 min by LANCE detection method
Inhibition of human recombinant MLK1 assessed as reduction in substrate phosphorylation at 500 nM using ATP and Ulight-FLGFTYVAP as substrate incubated for 60 min by LANCE detection method
Inhibition of MAP3K9 (unknown origin) at 1 uM measured after 1 hr relative to control
Assay data:5 Tested
Millipore Kinase Panel Assay from US Patent US8952027: "Inhibitors of syk and JAK protein kinases"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Mixed-Lineage Kinase Assay from Article 10.1021/jm8005838: "Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models."
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."
Assay data:16 Active, 16 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
KinomeScan assay: inhibition of MLK1
Assay data:108 Tested
MLK1(M3K9LGF1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
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