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Binding affinity towards human NPY2R in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:300 Tested
SummaryRelated BioAssays by Target
Agonist activity at human Y2R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP upto 10 uM after 1 hr by scintillation counting analysis
Assay data:2 Tested
Induction of internalization of C-terminal EYFP-tagged human Y2R transfected in HEK293 cells assessed as increase in fluorescence in intracellular vesicles at 100 nM measured after 1 hr by Hoechst33342 staining based live-cell microscopic analysis
Assay data:1 Active, 5 Tested
Agonist activity at human Y2R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 6 Tested
Y2 (h) CEREP panel
Assay data:1 Tested
Y2/HU Eurofins SafetyScreen44 (BI)
Neuropeptide Y Y2 Eurofins-Panlabs radioligand binding assay
Assay data:12 Tested
PRESTO-Tango GPCRome screening (NPY2R)
Y2/HU Eurofins-Panlabs selectivity data (BI)
Y2 CEREP ligand profiling
Y2 receptor CEREP ligand profiling
Y2 (h) Ligand binding assay
Y2 (h) CEREP ligand profiling
hNPY2 Cerep panel
Y2 (h) Eurofins-Cerep binding assay
Displacement of [3H]UR-MK299 from human neuropeptide Y Y2 receptor expressed in CHO cells measured after 90 mins by scintillation counting analysis
Assay data:21 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human NPY2 at 0.1 to 1 uM
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