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PAK4 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
PAK1 SGC Tm panel (DSF)
PAK4 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of PAK4 (unknown origin)
Assay data:3 Tested
Inhibition of PAK2 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of PAK1 (unknown origin) at 10 uM by biochemical hotspot kinase assay
PROTAC activity at PAK1/CRBN in human OVACR3 cells assessed as ERK phosphorylation at Thr202/Tyr204 at 10 nM measured after 24 hrs by immunoblot analysis
Assay data:1 Active, 2 Tested
PROTAC activity at PAK1/CRBN in human OVACR3 cells assessed as MEK phosphorylation at S298 at 10 nM measured after 24 hrs by immunoblot analysis
PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as ERK phosphorylation at Thr202/Tyr204 at 10 nM measured after 24 hrs by immunoblot analysis
PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as MEK phosphorylation at S298 at 10 nM measured after 24 hrs by immunoblot analysis
PROTAC activity at PAK1/CRBN in HEK293 cells transfected with Nluc-tagged PAK1 assessed as PAK1 degradation by measuring luciferase activity at 10 nM by Nano-Glo live cell assay relative to control
PROTAC activity at PAK1/CRBN in human OVACR-3 cells assessed as PAK1 degradation in presence of bortezomib measured after 24 hrs by immunoblot analysis
PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as PAK1 degradation in presence of bortezomib measured after 24 hrs by immunoblot analysis
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