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In vitro Assay (1 nM) from US Patent US20240043440: "COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY"
Assay data:91 Active, 35 Activity ≤ 1 nM, 100 Activity ≤ 1 µM, 100 Tested
SummaryRelated BioAssays by Target
In vitro Assay (5 nM) from US Patent US20240043440: "COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY"
Assay data:24 Active, 2 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Antagonist activity at 15-PGDH (unknown origin)
Assay data:1 Active, 1 Tested
In Vitro Assay from US Patent US11718589: "Compositions and methods of modulating short-chain dehydrogenase"
Assay data:124 Active, 119 Activity ≤ 1 µM, 164 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to 15-PGDH (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human 15-PGDH assessed as shift in melting temperature in presence of NADH by SYPRO orange dye based differential scanning fluorimetry assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of 15-PGDH (unknown origin) using PGE2 as substrate
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to 15-PGDH (unknown origin) assessed as Km using PGE2 as substrate
Inhibition of 15-PGDH (unknown origin) using NAD as substrate measured for 3.5 mins
Assay data:40 Active, 40 Activity ≤ 1 µM, 55 Tested
Biochemical Assay from US Patent US11345702: "PGDH inhibitors and methods of making and using"
Assay data:43 Active, 2 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 43 Tested
Inhibitory Activity Assay from US Patent US10787425: "Thiazolidinedione derivative and use thereof"
Assay data:105 Active, 97 Activity ≤ 1 µM, 105 Tested
Inhibition Assay from US Patent US8637558: "Thiazolidinedione derivative and use thereof"
Assay data:120 Active, 90 Activity ≤ 1 µM, 124 Tested
in vitro assay from US Patent US10301320: "Compositions and methods of modulating 15-PGDH activity"
Assay data:17 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 25 Tested
In Vitro Assay from US Patent US9790233: "Compositions and methods of modulating 15-PGDH activity"
Assay data:12 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 19 Tested
In Vitro Assay from US Patent US9789116: "Compositions and methods of modulating short-chain dehydrogenase activity"
Assay data:78 Active, 1 Activity ≤ 1 nM, 74 Activity ≤ 1 µM, 91 Tested
Inhibition of 15-PGDH (unknown origin) using PGE2 as substrate preincubated for 12 hrs followed by dialysis for 12 hrs and subsequent addition of NAD+ measured after 12 hrs
Inhibition of 15-PGDH (unknown origin) using PGE2 as substrate in presence of beta-NAD by spectrophotometric assay
Assay data:1 Active, 2 Tested
Inhibition of 15-PGDH in human A549 cells assessed as increase in IL-1beta-stimulated PGE2 levels at 2500 nM after 8 hrs by ELISA relative to DMSO
Assay data:50 Tested
Inhibition of 15-PGDH in human A549 cells assessed as increase in IL-1beta-stimulated PGE2 levels at 20 nM after 8 hrs by ELISA relative to DMSO
Inhibition of recombinant human C-terminal 6xHis-tagged 15-PGDH expressed in Escherichia coli using PGE2 as substrate after 15 mins in presence of NAD(+) by fluorescence assay
Assay data:62 Active, 3 Activity ≤ 1 nM, 61 Activity ≤ 1 µM, 68 Tested
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