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Interleukin IL-1 Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human IL1-R1 assessed as dissociation constant incubated for 5 mins by SPR analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Interleukin IL-1 R1 Eurofins-Panlabs radioligand binding assay
Assay data:3 Tested
Interleukin IL-1 Eurofins-Panlabs radioligand binding assay
Assay data:4 Tested
IL-1 Eurofins-Panlabs selectivity data (BI)
Displacement of [125I]-Interleukin 1beta from human interleukin IL-1 R1 receptor at 10 uM incubated for 120 mins by scintillation counting analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [125I]-Interleukin 1beta from human interleukin IL-1 R1 receptor assessed as residual binding level for radioligand at 10 uM incubated for 1200 mins by scintillation counting analysis relative to control
Antagonist activity at IL1R in human PBMC assessed as inhibition of IL1beta-induced TNFalpha production preincubated for 30 mins followed by IL1beta addition and measured after 20 hrs by HTRF assay
Inhibition of IL1R in human monocytes assessed as reduction in IL1beta-induced TNFalpha production
Inhibition of mouse IL1 receptor at 10 uM relative to control
Inhibition of mouse IL-1 receptor at 10 uM relative to control
Inhibition of IL1R in TLR null HEK-blue cells assessed as decrease in IL-1beta-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]interleukin-1beta from human recombinant IL-1 receptor at 10 uM after 20 hrs by scintillation counting method
Activation of IL-1R in human monocytes assessed as inhibition of IL-1beta-stimulated TNF-alpha production preincubated for 30 mins prior to IL-1beta stimulation at 1 uM measured after 6 hrs by immunoassay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of IL-1 receptor (unknown origin) at 10 uM
Inhibition of MyD88 recruitment to IL-1R in C57BL/6 mouse BMDM cells assessed as inhibition of IL-1-induced IkappaBalpha phosphorylation up to 90 mins by Western blot analysis
Inhibition of MyD88 recruitment to IL-1R in C57BL/6 mouse BMDM cells assessed as inhibition of IL-1-induced IkappaBalpha degradation up to 90 mins by Western blot analysis
Inhibition of MyD88 recruitment to IL-1R in C57BL/6 mouse BMDM cells assessed as inhibition of IL1-induced p38 MAPK activity up to 90 mins
Inhibitory activity against Interleukin 1d using [3H]IL-1-alpha at 10e5 (M)
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